Skip to main content
SpringerLink
Log in

Adrenal and renal corticomedullary junction iron deposition in red cell aplasia

  • Case Report
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Iron deposition can occur in the kidneys as a result of hemolysis or extensive iron overload from transfusions. With T2* MRI, renal iron deposition can be visualized. In this report, renal corticomedullary junction iron deposition is noted using T2* MRI in a boy with red cell aplasia. The renal corticomedullary junction iron deposition is an indication of the severity of his iron overload. This is an unusual finding and brings clinical attention to the boy’s renal function for further evaluation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Kushner JP, Porter JP, Olivieri NF (2001) Secondary iron overload. Hematology Am Soc Hematol Educ Program 47–61

  2. Rimola J, Martin J, Puig J et al (2004) The kidney in paroxysmal nocturnal haemoglobinuria: MRI findings. Br J Radiol 77:953–956

    Article  CAS  PubMed  Google Scholar 

  3. Lande IM, Glazer GM, Sarnaik S et al (1986) Sickle cell nephropathy: MR imaging. Radiology 158:379–383

    CAS  PubMed  Google Scholar 

  4. Schein A, Enriquez C, Coates TD et al (2008) Magnetic resonance detection of kidney iron deposition in sickle cell disease: a marker of chronic hemolysis. J Magn Reson Imaging 28:698–704

    Article  PubMed  Google Scholar 

  5. Hankins JS, McCarville MB, Loeffler RB et al (2009) R2* magnetic resonance imaging of the liver in patients with iron overload. Blood 113:4853–4855

    Article  CAS  PubMed  Google Scholar 

  6. Papakonstantinou O, Alexopoulou E, Economopoulos N et al (2009) Assessment of iron distribution between liver, spleen, pancreas, bone marrow, and myocardium by means of R2 relaxometry with MRI in patients with beta-thalassemia major. J Magn Reson Imag 29:853–859

    Article  Google Scholar 

  7. Yu H, McKenzie CA, Shimakawa A et al (2007) Multiecho reconstruction for simultaneous water-fat decomposition and T2* estimation. J Magn Reson Imaging 26:1153–1161

    Article  PubMed  Google Scholar 

  8. Chirnomas DS, Geukes-Foppen M, Barry K et al (2008) Practical implications of liver and heart iron load assessment by T2*-MRI in children and adults with transfusion-dependent anemia. Am J Hematol 83:781–783

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA

    Rebecca Rakow-Penner & Shreyas Vasanawala

  2. Department of Pediatric Hematology and Oncology, Stanford University School of Medicine, Stanford, CA, USA

    Bert Glader

  3. GE Healthcare, Global MR Applied Science Lab, Menlo Park, CA, USA

    Huanzhou Yu

  4. 725 Welch Road, Room 1679, MC 5913, Stanford, CA, 94305-5654, USA

    Shreyas Vasanawala

Authors
  1. Rebecca Rakow-Penner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bert Glader
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Huanzhou Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shreyas Vasanawala
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shreyas Vasanawala.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rakow-Penner, R., Glader, B., Yu, H. et al. Adrenal and renal corticomedullary junction iron deposition in red cell aplasia. Pediatr Radiol 40, 1955–1957 (2010). https://doi.org/10.1007/s00247-010-1824-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-010-1824-2

Keywords

Search

Navigation