Abstract
Neuroblastoma is often widespread at the time of diagnosis. Three physicians between 1900 and 1910 played an important role in the pathologic definition of neuroblastoma and its route of spread in relation to the age of the patient. These findings eventually led to the advances in treatment and decreased morbidity of today. In 1910 James Homer Wright was the first to recognize the tumor as being of primitive neural cell origin, calling it neuroblastoma and emphasizing the bundle of cells termed rosettes. While Wright recognized the neural nature of the tumor, the authors of previous reports had described its two distinct patterns of spread. In 1901 William Pepper published a series of infants with massive hepatic infiltration associated with adrenal tumors without spread to bone, and in 1907 Robert Grieve Hutchison reported his experience with a similar pathologic process in older infants and children who had orbital and skull metastases. Wright’s valuable unifying concept served to tie together the descriptions of Pepper and Hutchison. A century later the names of these physicians should be remembered—Wright, who defined the adrenal tumor as of primitive neural origin, Pepper for his clinically accurate report of massive liver involvement in the infant, and Hutchison for describing the propensity of the tumor to spread to bone in older children.
Similar content being viewed by others
References
Wright JH (1910) Neurocytoma or neuroblastoma: a kind of tumor not generally recognized. J Exp Med 12:556–561
Pepper WA (1901) A study of congenital sarcoma of the liver and suprarenal with report of a case. Am J Med Sci (1827–1924) 121:287–299
Hutchison R (1907) On suprarenal sarcoma in children with metastases to the skull. Q J Med 1:33–38
Lee RE, Young RH, Castleman B (2002) James Homer Wright: a biography of the enigmatic creator of the Wright stain on the occasion of its centennial. Am J Surg Pathol 26:88–96
Dargeon HW (1960) Tumors of the peripheral nervous system. Tumors of childhood — a clinical treatise. Paul Hoeber, New York, pp 142–159
Gross RW, Farber S, Martin LW (1959) Neuroblastoma sympatheticum – a study and report of 217 cases. Pediatrics 23:1179–1191
Wittenborg MH (1950) Roentgen therapy in neuroblastoma: a review of 73 cases. Radiology 54:679–685
Evans AE, D’Angio GJ, Randolph J (1971) A proposed staging for children with neuroblastoma. Cancer 27:374–378
Brodeur GM, Pritchard J, Berthold F et al (1993) Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J Clin Oncol 11:1466–1477
Brodeur GM (2003) Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer 3:203–216
Acknowledgement
To R.B., my best and most loyal fan. W.B.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rothenberg, A.B., Berdon, W.E., D’Angio, G.J. et al. Neuroblastoma—remembering the three physicians who described it a century ago: James Homer Wright, William Pepper, and Robert Hutchison. Pediatr Radiol 39, 155–160 (2009). https://doi.org/10.1007/s00247-008-1062-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00247-008-1062-z