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Primary hypothyroidism mimicking a pituitary macroadenoma: regression after thyroid hormone replacement therapy

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Abstract

We report a 9-year-old girl with pituitary hyperplasia due to primary hypothyroidism. She presented with growth arrest, abnormal thyroid function studies, and a pituitary mass on MRI. With thyroxine therapy, the pituitary mass regressed and her symptoms resolved. Primary hypothyroidism should be considered in the differential diagnosis of solid mass lesions of the pituitary gland.

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References

  1. Joshi AS, Woolf PD (2005) Pituitary hyperplasia secondary to primary hypothyroidism: a case report and review of the literature. Pituitary 8:99–103

    Article  PubMed  Google Scholar 

  2. Koller KJ, Wolff RS, Warden MK (1987) Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Proc Natl Acad Sci U S A 84:7329–7333

    Article  PubMed  CAS  Google Scholar 

  3. Beck-Peccoz P, Brucker-Davis F, Persani L (1996) Thyrotropin-secreting pituitary tumors. Endocr Rev 17:610–638

    Article  PubMed  CAS  Google Scholar 

  4. Khawaja NM, Taher BM, Barham ME (2006) Pituitary enlargement in patients with primary hypothyroidism. Endocr Pract 12:29–34

    PubMed  Google Scholar 

  5. Shimono T, Hatabu H, Kasagi K (1999) Rapid progression of pituitary hyperplasia in humans with primary hypothyroidism: demonstration with MR imaging. Radiology 213:383–388

    PubMed  CAS  Google Scholar 

  6. Connor SE, Penney CC (2003) MRI in the differential diagnosis of a sellar mass. Clin Radiol 58:20–31

    Article  PubMed  CAS  Google Scholar 

  7. Desai MP, Mehta RU, Choksi CS (1996) Pituitary enlargement on magnetic resonance imaging in congenital hypothyroidism. Arch Pediatr Adolesc Med 150:623–628

    PubMed  CAS  Google Scholar 

  8. Osborne AG (2004) Pituitary macroadenoma. In: Osborn AG (eds) Diagnostic imaging: brain. Amirsys, Salt Lake City, pp II-2–24

    Google Scholar 

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Acknowledgement

This work was supported by Wonkwang Institute of Clinical Medicine in 2008.

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Authors and Affiliations

  1. Department of Neurosurgery, Wonkwang University School of Medicine, 344-2 Shinyong-dong, Iksan, 570-711, Korea

    Ki Seong Eom, Jong Moon Kim & Tae Young Kim

  2. Department of Radiology, Wonkwang University School of Medicine, Iksan, Korea

    Choi See-Sung

  3. Department of Pediatrics, Wonkwang University School of Medicine, Iksan, Korea

    Jong Duck Kim

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  1. Ki Seong Eom
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  2. Choi See-Sung
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  3. Jong Duck Kim
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  4. Jong Moon Kim
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  5. Tae Young Kim
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Correspondence to Tae Young Kim.

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Eom, K.S., See-Sung, C., Kim, J.D. et al. Primary hypothyroidism mimicking a pituitary macroadenoma: regression after thyroid hormone replacement therapy. Pediatr Radiol 39, 164–167 (2009). https://doi.org/10.1007/s00247-008-1012-9

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  • DOI: https://doi.org/10.1007/s00247-008-1012-9

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