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Molecular Evolution of Peptide Methionine Sulfoxide Reductases (MsrA and MsrB): On the Early Development of a Mechanism That Protects Against Oxidative Damage

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Abstract

Methionine sulfoxide reductases, enzymes that reverse the oxidation of methionine residues, have been described in a wide range of species. The reduction of the diastereoisomers of oxidized methionine is catalyzed by two different monomeric methionine sulfoxide reductases (MsrA and MsrB) and is best understood as an evolutionary response to high levels of oxygen either in the Earth’s atmosphere or possibly in more localized environments. Phylogenetic analyses of these proteins suggest that their distribution is the outcome of a complex history including many paralogy and lateral gene transfer events.

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Acknowledgments

We are indebted to Professor Russell Doolittle for his critical reading of the manuscript and to Drs. David DesMarais and David E. Graham for several useful exchanges and for providing us with important references.

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Authors and Affiliations

  1. Facultad de Ciencias, UNAM, Apartado Postal 70-407, Cd. Universitaria, 04510, Mexico D.F., México

    Luis Delaye, Arturo Becerra & Antonio Lazcano

  2. Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Leslie Orgel

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  1. Luis Delaye
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  2. Arturo Becerra
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  3. Leslie Orgel
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  4. Antonio Lazcano
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Correspondence to Antonio Lazcano.

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[Reviewing Editor: Dr. Martin Kreitman]

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Delaye, L., Becerra, A., Orgel, L. et al. Molecular Evolution of Peptide Methionine Sulfoxide Reductases (MsrA and MsrB): On the Early Development of a Mechanism That Protects Against Oxidative Damage. J Mol Evol 64, 15–32 (2007). https://doi.org/10.1007/s00239-005-0281-2

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  • DOI: https://doi.org/10.1007/s00239-005-0281-2

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