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Comparison of hemodynamics of intracranial aneurysms between MR fluid dynamics using 3D cine phase-contrast MRI and MR-based computational fluid dynamics

  • Interventional Neuroradiology
  • Published:
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Abstract

Introduction

Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to compare hemodynamics of intracranial aneurysms of MR fluid dynamics (MRFD) using 3D cine PC MR imaging (4D-Flow) at 1.5 T and MR-based computational fluid dynamics (CFD).

Methods

4D-Flow was performed for five intracranial aneurysms by a 1.5 T MR scanner. 3D TOF MR angiography was performed for geometric information. The blood flow in the aneurysms was modeled using CFD simulation based on the finite element method. We used MR angiographic data as the vascular models and MR flow information as boundary conditions in CFD. 3D velocity vector fields, 3D streamlines, shearing velocity maps, wall shear stress (WSS) distribution maps and oscillatory shear index (OSI) distribution maps were obtained by MRFD and CFD and were compared.

Results

There was a moderate to high degree of correlation in 3D velocity vector fields and a low to moderate degree of correlation in WSS of aneurysms between MRFD and CFD using regression analysis. The patterns of 3D streamlines were similar between MRFD and CFD. The small and rotating shearing velocities and higher OSI were observed at the top of the spiral flow in the aneurysms. The pattern and location of shearing velocity in MRFD and CFD were similar. The location of high oscillatory shear index obtained by MRFD was near to that obtained by CFD.

Conclusion

MRFD and CFD of intracranial aneurysms correlated fairly well.

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Acknowledgment

This study was supported by a grant from the Information-Technology Promotion Agency, Japan.

Conflict of interest statement

Dr. H. Isoda received a grant from the Renaissance of Technology Corporation.

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Authors and Affiliations

  1. Department of Radiology, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan

    Haruo Isoda & Harumi Sakahara

  2. Renaissance of Technology Corporation, 1-4-10 Shinmiyakoda Kitaku, Hamamatsu, Shizuoka, 431-2103, Japan

    Yasuhide Ohkura & Takashi Kosugi

  3. GE Healthcare Japan, 4-7-127 Asahigaoka Hino, Tokyo, 191-0065, Japan

    Masaya Hirano

  4. Department of Radiology, Radiological Sciences Laboratory, Stanford University School of Medicine, Stanford, CA, 94305-5488, USA

    Marcus T. Alley, Roland Bammer & Norbert J. Pelc

  5. Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama Higashiku, Hamamatsu, Shizuoka, 431-3192, Japan

    Hiroki Namba

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  1. Haruo Isoda
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  2. Yasuhide Ohkura
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  9. Harumi Sakahara
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Correspondence to Haruo Isoda.

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Isoda, H., Ohkura, Y., Kosugi, T. et al. Comparison of hemodynamics of intracranial aneurysms between MR fluid dynamics using 3D cine phase-contrast MRI and MR-based computational fluid dynamics. Neuroradiology 52, 913–920 (2010). https://doi.org/10.1007/s00234-009-0634-4

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  • DOI: https://doi.org/10.1007/s00234-009-0634-4

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