Abstract
We studied seven patients with corticobasal degeneration (CBD) from a clinical and imaging perspective. We describe the main morphological features of CBD and, using functional MRI, try to define the possible role of the parietal lobe in simple and complex learned motor sequences. We showed decreased activation of the parietal lobe contralateral to the more affected arm, when movements, simple or complex, are performed with that hand. Moreover we found that functional imaging can demonstrate parietal and motor cortex dysfunction before structural, and even single-photon emission computed tomography changes become evident.
Similar content being viewed by others
References
Riley D, Lang A, Lewis A., et al (1990) Cortical-basal ganglionic degeneration. Neurology 40: 1203–1212
Rinne J, Lee M, Thompson P, Marsden C (1994) Corticobasal degeneration: a clinical study of 36 cases. Brain 117: 1183–1196
Lang A (1994) Cortico-basal ganglionic degeneration. In: Calne DB (ed) Neurodegenerative diseases. Saunders, Philadelphia, pp 877–894
Grimes DA, Lang AE, Bergeron C (1998) Dementia is the most common presentation of cortical-basal ganglionic degeneration. Neurology 50 [Suppl 4]: A96
Revesz T, Geddes JF, Daniel SE (1995) Corticobasal degeneration. In: Cruz-Sánchez FF, Ravid R, Cuzner ML (eds) Neuropathological diagnostic criteria for brain banking. Amsterdam Press, Amsterdam pp 99–104
Litvan I, Agid Y, Goetz C (1997) Accuracy of the clinical diagnosis of corticobasal degeneration: a clinicopathologic study. Neurology 48: 119–125
Gibb WRC, Luthert PJ, Marsden CD(1990) Clinical and pathological features of corticobasal degeneration. Adv Neurol 53: 51–54
Feary MB, Dickson DW (1995) Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol 146: 1338–1396
Schneider JA, Watts RL, Gearing M, Mirra SS (1997) Corticobasal degeneration: neuropathologic and clinical heterogeneity. Neurology 48: 959–969
Leiguarda R, Lees A, Morello M, Marsden C(1994) The nature of apraxia in corticobasal degeneration. J Neurol Neurosurg Psychiatry 57: 455–459
Briggs GC, Nebes R.D (1975) Patterns of hand preference in a student population. Cortex 11: 230–238
Raven JC (1938) Standard progressive matrices. H.K. Lewis, London
Spinnler H, Tognoni G (1987) Standardizzazione e taratura italiana dei test neuropsicologici. Ital J Neurol Sci [Suppl 6]: 23–116
Wechsler D (1995) Wechsler adult intelligence scale manual. Grune & Stratton, New York
Poeck K (1994) Neurologie. Springer-Verlag, Berlin, pp 58–73
Wechsler D (1945) A standardized memory scale for clinical use. J Psychol 19: 87–97
Benton L, Hamsher K, Varney N, Spreen O (1983) Contributions to neuropsychological assessment. Oxford University Press, New York
Manos PJ, Wu R (1994) The ten point test: a quick screen and grading method for cognitive impairment in medical and surgical patients. Int J Psych Med 24: 229–244
Sobol WT, Gaunt DM (1996) On the stationary states in gradient echo imaging. J Magn Reson Imag 6: 384–398
Salvador S, Brovelli A, Longo R (2002) A simple and fast technique for on-line f-MRI data analysis. Magn Reson Imaging 20: 207–213
Ballan G, Tison F, Dousset V, Vidailhet M, Agid Y, Henry P (1998) Study of cortical atrophy with magnetic resonance imaging in corticobasal degeneration. Rev Neurol 154: 224–227
Markus HS, Lees AJ, Lennox G, Marsden CD, Costa DC (1995) Patterns of regional cerebral blood flow in corticobasal degeneration studied using HMPAO-SPECT; comparison with Parkinson's disease and normal controls. Mov Disord 10: 179–187
Roland PE (1997) Brain activation: motor functions. Wiley-Liss, New York, pp 105–108
Rizzolatti G, Luppino G, Matelli M (1996) The classic supplementary motor area is formed by two independent areas. In: Lunders HO (ed): Supplementary sensorimotor area. Lippincott Raven, Philadelphia, pp 45–56
Wiesendanger M, Kazennikov O, Perrig S, Roviller E, Kermadi I (1997) Reaching, grasping and bimanual coordination with special reference to the posterior parietal cortex. In: Thier P, Karnath HO (eds) Parietal lobe contributions to orientation in 3D space. Springer-Verlag, Berlin, pp 271–288
Mountcastle VB (1995) The parietal system and some higher brain functions. Cereb Cortex 5: 377–390
Glickstein M (2000) How are visual areas of the brain connected to motor areas for the sensory guidance of movement? Trends Neurosci 23: 613–617
Acknowledgements
This study was supported by grants from the Ministero dell'Università e della Ricerca Scientifica e tecnologica, Roma, from the Università degli Studi di Trieste and from the Consorzio per lo Sviluppo Internazionale dell'Università degli Studi di Trieste and by Fondazione C. e D. Callerio, Laboratori di Ricerche Biologiche, Trieste, Italia.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ukmar, M., Moretti, R., Torre, P. et al. Corticobasal degeneration: structural and functional MRI and single-photon emission computed tomography. Neuroradiology 45, 708–712 (2003). https://doi.org/10.1007/s00234-003-1058-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00234-003-1058-1