Abstract
Sample preparation is an important step in the development of an analytical method but is often regarded as time-consuming, laborious work. Optimum sample preparation leads to enhanced selectivity and sensitivity, however, and reduces amounts of interfering matrix compounds, resulting in less signal suppression or enhancement. Recent developments in extraction techniques that could be of interest in clinical and forensic toxicology, for example liquid–liquid, solid-phase, and headspace extraction, are summarized in this review. The advantages and disadvantages of several extraction techniques are discussed, to enable the reader to choose an appropriate method of extraction for his or her application. Attention is paid to current trends in analytical toxicology, for example miniaturization, high throughput, and automation.
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References
Ramsey ED (Ed.) (1998) Analytical supercritical fluid extraction techniques. Springer, Berlin Heidelberg New York
Fritz JS (1999) Analytical solid-phase extraction. Wiley–VCH, New York
Thurman EM, Mills MS (1998) Solid-phase extraction. Principles and practice. Wiley, New York, p 147
Quintela O, Cruz A, de Castro A, Concheiro M, Lopez-Rivadulla M (2005) J Chromatogr B 825:63–71
Hoizey G, Lamiable D, Trenque T, Robinet A, Binet L, Kaltenbach ML, Havet S, Millart H (2005) Clin Chem 51:1666–1672
Paterson S, Cordero R, Burlinson S (2004) J Chromatogr B 813:323–330
Pragst F, Herzler M, Erxleben BT (2004) Clin Chem Lab Med 42:1325–1340
Kratzsch C, Tenberken O, Peters FT, Weber AA, Kraemer T, Maurer HH (2004) J Mass Spectrom 39:856–872
Rivera HM, Walker GS, Sims DN, Stockham PC (2003) Eur J Mass Spectrom 9:599–607
Goeringer KE, Raymon L, Christian GD, Logan BK (2000) J Forensic Sci 45:633–648
Drummer OH, Gerostamoulos J (2002) Ther Drug Monit 24:199–209
Drummer OH (1999) J Chromatogr B 733:27–45
Walker V, Mills GA (2002) Ann Clin Biochem 39:464–477
He Y, Kang Y-J (2006) J Chromatogr A 1133:35–60
Majors RE (2006) LC GC N Am 24:118
Barri T, Jonsson JA (2004) Chromatographia 59:161–165
Trocewicz J (2001) J Sep Sci 24:587–592
Trocewicz J (2004) J Chromatogr B 801:213–220
Pedersen-Bjergaard S, Rasmussen KE (2005) J Chromatogr B 817:3–12
Miyaguchi H, Tokeshi M, Kikutani Y, Hibara A, Inoue H, Kitamori T (2006) J Chromatogr A 1129:105–110
Dotsikas Y, Kousoulos C, Tsatsou G, Loukas YL (2006) J Chromatogr B 836:79–82
Dotsikas Y, Kousoulos C, Tsatsou G, Loukas YL (2005) Rapid Commun Mass Spectrom 19:2055–2061
Basileo G, Breda M, Fonte G, Pisano R, James CA (2003) J Pharm Biomed Anal 32:591–600
Bolden RD, Hoke SH, Eichhold TH, McCauley-Myers DL, Wehmeyer KR (2002) J Chromatogr B 772:1–10
Brignol N, McMahon LM, Luo S, Tse FLS (2001) Rapid Commun Mass Spectrom 15:898–907
Zhang NY, Hoffman KL, Li WL, Rossi DT (2000) J Pharm Biomed Anal 22:131–138
Staub C (1997) Forensic Sci Int 84:295–304
Brewer WE, Galipo RC, Sellers KW, Morgan SL (2001) Anal Chem 73:2371–2376
Allen DL, Oliver JS (2000) Forensic Sci Int 107:191–199
Goodpaster JV, Bishop JJ, Benner BA (2003) J Sep Sci 26:137–141
Huck CW, Bonn GK (2000) J Chromatogr A 885:51–72
Shukla A, Majors RE (2005) LC GC N Am 23:646
Van Horne KC (1985) Sorbent extraction technology, Analytichem International.
Pyrzynska K (2003) Chem Anal 48:781–795
Kowalczuk D, Hopkala H, Gumieniezek A (2003) J Liq Chromatogr Relat Technol 26:1731–1741
Teske J, Putzbach K, Engewald W, Muller RK (2002) J Chromatogr B 772:299–306
Dawson R, Messina SM, Stokes C, Salyani S, Alcalay N, de Fiebre NC, de Fiebre CM (2002) Toxicol Mech Methods 12:45–58
Ensing K, Franke JP, Temmink A, Chen XH, de Zeeuw RA (1992) J Forensic Sci 37:460–466
Rittner M, Pragst F, Bork WR, Neumann J (2001) J Anal Toxicol 25:115–124
Qi LN, Danielson ND (2005) J Pharm Biomed Anal 37:225–230
Franke JP, de Zeeuw RA (1998) J Chromatogr B 713:51–59
Wang AQ, Zeng W, Musson DG, Rogers JD, Fisher AL (2002) Rapid Commun Mass Spectrom 16:975–981
Wang AQ, Zeng W, Musson DG, Rogers JD, Fisher AL (2002) Rapid Commun Mass Spectrom 16:1610–1610
Peng SX, Branch TM, King SL (2001) Anal Chem 73:708–714
Bahrami G, Kiani A, Mirzaeei S (2006) J Chromatogr B 832:197–201
Li WL, Rossi DT, Fountain ST (2000) J Pharm Biomed Anal 24:325–333
Danaher M, O’Keeffe M, Glennon JD (2000) Analyst 125:1741–1744
Anon. (2006) LC GC N Am 13
Williams L, Lodder H, Merriman S, Howells A, Jordan S, Labadie J, Cleeve M, Desbrow C, Calverley R, Burke M (2006) LC GC N Am 12–13
Wille SMR, Maudens KE, Van Peteghem CH, Lambert WEE (2005) J Chromatogr A 1098:19–29
Xue YJ, Akinsanya JB, Liu J, Unger SE (2006) Rapid Commun Mass Spectrom 20:2660–2668
Mallett DN, Dayal S, Dear GJ, Pateman AJ (2006) J Pharm Biomed Anal 41:510–516
King T, Bushman L, Anderson PL, Delahunty T, Ray M, Fletcher CV (2006) J Chromatogr B 831:248–257
Wang QQ, Gu MS, Feng JL, Ruan JX (2006) Chin J Anal Chem 34:5–9
Huq S, Dixon A, Garriques M, Kallury K (2005) LC GC N Am 63–63
Wang QQ, Xie JW, Gu MS, Feng JL, Ruan JX (2005) Chromatographia 62:167–173
Li KM, Rivory LP, Clarke SJ (2005) J Chromatogr B 820:121–130
Rodriguez-Rosasa ME, Medrano JG, Epstein DH, Moolchan ET, Preston KL, Wainer IW (2005) J Chromatogr A 1073:237–248
Koseki N, Kawashita H, Niina M, Nagae Y, Masuda N (2005) J Pharm Biomed Anal 36:1063–1072
Zhao M, Rudek MA, He P, Hartke C, Gore S, Carducci MA, Baker SD (2004) J Chromatogr B 813:81–88
Lindgardh N, Ashton M, Bergqvist Y (2003) Ther Drug Monit 25:544–551
Shi G, Lloyd TL, Sy SKB, Jiao Q, Wernicki A, Mutlib A, Emm TA, Unger SE, Pieniaszek HJ (2003) J Pharm Biomed Anal 31:937–951
Segura M, Ortuno J, Farre M, McLure JA, Pujadas M, Pizarro N, Llebaria A, Joglar J, Roset PN, Segura J, de la Torre R (2001) Chem Res Toxicol 14:1203–1208
Zhong L, Eisenhandler R, Yeh KC (2001) J Mass Spectrom 36:736–741
Moore JD, Valette G, Darque A, Zhou XJ, Sommadossi JP (2000) J Am Soc Mass Spectrom 11:1134–1143
Chen XH, Franke JP, Wijsbeek J, de Zeeuw RA (1994) J Anal Toxicol 18:150–153
Chen XH, Franke JP, Ensing K, Wijsbeek J, de Zeeuw RA (1993) J Anal Toxicol 17:421–426
Chen XH, Franke JP, Wijsbeek J, de Zeeuw RA (1993) J Chromatogr B 619:137–142
Chen XH, Franke JP, Wijsbeek J, de Zeeuw RA (1992) J Anal Toxicol 16:351–355
Chen XH, Wijsbeek J, Franke JP, de Zeeuw RA (1992) J Forensic Sci 37:61–71
Soriano T, Jurado C, Menendez M, Repetto M (2001) J Anal Toxicol 25:137–143
Su P, Zhang XX, Chang WB (2005) J Chromatogr B 816:7–14
Hupka Y, Beike J, Roegener J, Brinkmann B, Blaschke G, Kohler H (2005) Int J Legal Med 119:121–128
Nichkova M, Marco MP (2005) Anal Chim Acta 533:67–82
Widstrand C, Larsson F, Fiori M, Civitareale C, Mirante S, Brambilla G (2004) J Chromatogr B 804:85–91
Abdel-Rehim M, Andersson LI, Altun Z, Blomberg LG (2006) J Liq Chromatogr Relat Technol 29:1725–1736
Suedee R, Seechamnanturakit V, Canyuk B, Ovatiarnporn C, Martin GP (2006) J Chromatogr A 1114:239–249
Caro E, Marce RM, Cormack PAG, Sherrington DC, Borrull F (2006) Anal Chim Acta 562:145–151
Caro E, Marce RM, Cormack PAG, Sherrington DC, Borrull F (2005) Anal Chim Acta 552:81–86
Tang YW, Huang ZF, Yang T, Hu XG, Jiang XO (2005) Anal Lett 38:219–226
Caro E, Marce RM, Cormack PAG, Sherrington DC, Borrull F (2004) J Chromatogr B 813:137–143
Andersson LI, Hardenborg E, Sandberg-Stall M, Moller K, Henriksson J, Bramsby-Sjostrom I, Olsson LI, Abdel-Rehim M (2004) Anal Chim Acta 526:147–154
Theodoridis G, Zacharis CK, Tzanavaras PD, Themelis DG, Economou A (2004) J Chromatogr A 1030:69–76
Mullett WM, Walles M, Levsen K, Borlak J, Pawliszyn J (2004) J Chromatogr B 801:297–306
Sanbe H, Haginaka J (2003) Analyst 128:593–597
Hennion MC, Pichon V (2003) J Chromatogr A 1000:29–52
Stevenson D (2000) J Chromatogr B 745:39–48
Delaunay N, Pichon V, Hennion MC (2000) J Chromatogr B 745:15–37
Poole CF (2003) Trends Anal Chem 22:362–373
Hennion MC (1999) J Chromatogr A 856:3–54
Caro E, Marce RM, Borrull F, Cormack PAG, Sherrington DC (2006) Trends Anal Chem 25:143–154
Souverain S, Rudaz S, Veuthey JL (2004) J Chromatogr B 801:141–156
Veuthey JL, Souverain S, Rudaz S (2004) Ther Drug Monit 26:161–166
Cassiano NM, Lima VV, Oliveira RV, de Pietro AC, Cass QB (2006) Anal Bioanal Chem 384:1462–1469
Egle H, Trittler R, Konig A, Kummerer K (2005) J Chromatogr B 814:361–367
Vintiloiu A, Mullett WM, Papp R, Lubda D, Kwong E (2005) J Chromatogr A 1082:150–157
Huclova J, Satinsky D, Maia T, Karlicek R, Solich P, Araujo AN (2005) J Chromatogr A 1087:245–251
Christiaens B, Fillet A, Chiap P, Rbeida O, Ceccato A, Streel B, De Graeve J, Crommen J, Hubert P (2004) J Chromatogr A 1056:105–110
Rbeida O, Chiap P, Lubda D, Boos KS, Crommen J, Hubert P (2005) Journal of Pharmaceutical and Biomedical Analysis 36:961–968
Rbeida O, Christiaens B, Hubert P, Lubda D, Boos KS, Crommen J, Chiap P (2004) J Chromatogr A 1030:95–102
Rbeida O, Christiaens B, Hubert P, Lubda D, Boos KS, Crommen J, Chiap P (2005) J Pharm Biomed Anal 36:947–954
Neto AJS, Rodrigues JC, Fernandes C, Titato GM, Alves C, Lancas FM (2006) J Chromatogr A 1105:71–76
Snow NH, Slack GC (2002) Trends Anal Chem 21:608–617
Couper FJ, Chopra K, Pierre-Louis MLY (2005) Forensic Sci Int 153:71–73
Moriya F, Hashimoto Y (2005) Forensic Sci Int 148:139–142
Avella J, Lehrer M (2004) J Forensic Sci 49:1361–1363
Yang NC, Hwang KL, Shen CH, Wang HF, Ho WM (2001) J Chromatogr B 759:307–318
Wille SMR, Lambert WEE (2004) Forensic Sci Int 142:135–156
Johns DO, Dills RL, Morgan MS (2005) J Chromatogr B 817:255–261
Brcic I, Skender L (2003) J Sep Sci 26:1225–1229
Prieto MJ, Berenguer V, Marhuenda D, Cardona A (2000) J Chromatogr B 741:301–306
Musshoff F, Lachenmeier DW, Kroener L, Madea B (2002) J Chromatogr A 958:231–238
Lachenmeier DW, Kroener L, Musshoff F, Madea B (2003) Rapid Commun Mass Spectrom 17:472–478
Wood DC, Miller JM, Christ I (2004) LC GC N Am 22:516
Watanabe-Suzuki K, Ishii A, Seno H, Takeuchi Y, Suzuki O (2001) Chromatographia 54:507–510
Kojima T, Ishii A, Watanabe-Suzuki K, Kurihara R, Seno H, Kumazawa T, Suzuki O, Katsumata Y (2001) J Chromatogr B 762:103–108
Kondo K, Lee XP, Kumazwa T, Sato K, Watanabe-Suzuki K, Seno H, Suzuki O (2001) J AOAC Int 84:19–23
De Martinis BS, Martin CCS (2002) Forensic Sci Int 128:115–119
Sporkert F, Pragst F (2000) Forensic Sci Int 107:129–148
Sporkert F, Pragst F, Hubner S, Mills G (2002) J Chromatogr B 772:45–51
Tranthim-Fryer DJ, Hansson RC, Norman KW (2001) J Forensic Sci 46:934–946
Frison G, Tedeschi L, Maietti S, Ferrara SD (2000) Rapid Commun Mass Spectrom 14:2401–2407
Rossi DT, Zhang N (2000) J Chromatogr A 885:97–113
Kousoulos C, Tsatsou G, Apostolou C, Dotsikas Y, Loukas YL (2006) Anal Bioanal Chem 384:199–207
Zhang NY, Yang A, Rogers JD, Zhao JJ (2004) J Pharm Biomed Anal 34:175–187
Stimpfl T, Vycudilik W (2004) Forensic Sci Int 142:115–125
Kim HY, Chang KY, Lee HJ, Han SB, Lee KR (2004) J Pharm Biomed Anal 34:661–669
Wang PG, Wei JS, Kim G, Chang M, Ei-Shourbagy T (2006) J Chromatogr A 1130:302–307
Qi S, Junga H, Yong T, Li AC, Addison T, McCort-Tipton M, Beato B, Weng ND (2005) J Chromatogr B 814:105–114
Yang LY, Clement RP, Kantesaria B, Reyderman L, Beaudry F, Grandmaison C, Di Donato L, Masse R, Rudewicz PJ (2003) J Chromatogr B 792:229–240
Pommier F, Boschet F, Gosset G (2003) J Chromatogr B 783:199–205
Shou WZ, Jiang XY, Beato BD, Weng ND (2001) Rapid Commun Mass Spectrom 15:466–476
Rose MJ, Merschman SA, Eisenhandler R, Woolf EJ, Yeh KC, Lin L, Fang W, Hsieh J, Braun MP, Gatto GJ, Matuszewski BK (2000) J Pharm Biomed Anal 24:291–305
McMahon LM, Luo SY, Hayes M, Tse FLS (2000) Rapid Commun Mass Spectrom 14:1965–1971
Jemal M, Huang M, Mao Y, Whigan D, Schuster A (2000) Rapid Commun Mass Spectrom 14:1023–1028
Eichhold TH, Bailey RE, Tanguay SL, Hoke SH (2000) J Mass Spectrom 35:504–511
Rule G, Chapple M, Henion J (2001) Anal Chem 73:439–443
Biddlecombe RA, Benevides C, Pleasance S (2001) Rapid Commun Mass Spectrom 15:33–40
Souverain S, Rudaz S, Veuthey JL (2004) J Chromatogr A 1058:61–66
Benner BA, Goodpaster JV, DeGrasse JA, Tully LA, Levin BC (2003) J Forensic Sci 48:554–563
Mauri-Aucejo AR, Pascual-Marti MC, Llobat M, Herraiz A, Cerdan A (2001) Microchem J 69:199–204
Xu XH, Yan KX, Song HC, Lo MW (2005) J Chromatogr B 814:29–36
Christiaens B, Chiap P, Rbeida O, Cello D, Crommen J, Hubert P (2003) J Chromatogr B 795:73–82
Chiap P, Rbeida O, Christiaens B, Hubert P, Lubda D, Boos KS, Crommen J (2002) J Chromatogr A 975:145–155
Kim DH, Lee SK, Park YH, Lee DW (2002) J Liq Chromatogr Relat Technol 25:433–443
Kema IP, Meijer WG, Meiborg G, Ooms B, Willemse PHB, de Vries EGE (2001) Clin Chem 47:1811–1820
Ceglarek U, Lembcke J, Fiedler GM, Werner M, Witzigmann H, Hauss JP, Thiery J (2004) Clin Chim Acta 346:181–190
Ceglarek U, Casetta B, Lembeke J, Baumann S, Fiedler GM, Thiery J (2006) Clin Chim Acta 373:168–171
Zang X, Luo R, Song N, Chen TK, Bozigian H (2005) Rapid Commun Mass Spectrom 19:3259–3268
Pyrzynska K, Pobozy E (2002) Crit Rev Anal Chem 32:227–243
Georgi K, Boos KS (2006) Chromatographia 63:523–531
Hyotylainen T, Riekkola ML (2005) J Chromatogr B 817:13–21
Abdel-Rehim M, Hassan Z, Blomberg L, Hassan M (2003) Ther Drug Monit 25:400–406
Abdel-Rehim M (2004) J Chromatogr B 801:317–321
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Wille, S.M.R., Lambert, W.E.E. Recent developments in extraction procedures relevant to analytical toxicology. Anal Bioanal Chem 388, 1381–1391 (2007). https://doi.org/10.1007/s00216-007-1294-z
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DOI: https://doi.org/10.1007/s00216-007-1294-z