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Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats

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Abstract

Rationale and objectives

Behavioral, neurochemical and pharmaco-EEG profiles of a new synthetic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats were examined.

Materials and methods

Locomotor effects, prepulse inhibition (PPI) of acoustic startle reaction (ASR), dopamine and its metabolite levels in nucleus accumbens (NAc), EEG power spectra and coherence in freely moving rats were analysed. Amphetamine was used as a reference compound.

Results

2C-B had a biphasic effect on locomotion with initial inhibitory followed by excitatory effect; amphetamine induced only hyperlocomotion. Both drugs induced deficits in the PPI; however they had opposite effects on ASR. 2C-B increased dopamine but decreased 3,4-dihydroxyphenylacetic acid (DOPAC) in the NAc. Low doses of 2C-B induced a decrease in EEG power spectra and coherence. On the contrary, high dose of 2C-B 50 mg/kg had a temporally biphasic effect with an initial decrease followed by an increase in EEG power; decrease as well as increase in EEG coherence was observed. Amphetamine mainly induced an increase in EEG power and coherence in theta and alpha bands. Increases in the theta and alpha power and coherence in 2C-B and amphetamine were temporally linked to an increase in locomotor activity and DA levels in NAc.

Conclusions

2C-B is a centrally active compound similar to other hallucinogens, entactogens and stimulants. Increased dopamine and decreased DOPAC in the NAc may reflect its psychotomimetic and addictive potential and monoaminoxidase inhibition. Alterations in brain functional connectivity reflected the behavioral and neurochemical changes produced by the drug; a correlation between EEG changes and locomotor behavior was observed.

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References

  • Acuna-Castillo C, Villalobos C, Moya PR, Saez P, Cassels BK, Huidobro-Toro JP (2002) Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT(2A) and 5-HT(2C) receptors. Br J Pharmacol 136:510–519

    Article  PubMed  CAS  Google Scholar 

  • Adams LM, Geyer MA (1982) LSD-induced alterations of locomotor patterns and exploration in rats. Psychopharmacol (Berl) 77:179–185

    Article  CAS  Google Scholar 

  • Ambrosini MV, Gambelunghe C, Mariucci G, Bruschelli G, Adami M, Giuditta A (1994) Sleep-wake variables and EEG power spectra in Mongolian gerbils and Wistar rats. Physiol Behav 56:963–968

    Article  PubMed  CAS  Google Scholar 

  • Berankova K, Szkutova M, Balikova M (2007) Distribution profile of 2,5-dimethoxy-4-bromoamphetamine (DOB) in rats after oral and subcutaneous doses. Forensic Sci Int 170:94–99

    Article  PubMed  CAS  Google Scholar 

  • Bossong MG, Van Dijk JP, Niesink RJ (2005) Methylone and mCPP, two new drugs of abuse? Addict Biol 10:321–323

    Article  PubMed  CAS  Google Scholar 

  • Bourin M, Petit-Demouliere B, Dhonnchadha BN, Hascoet M (2007) Animal models of anxiety in mice. Fundam Clin Pharmacol 21:567–574

    Article  PubMed  CAS  Google Scholar 

  • Breier A, Adler CM, Weisenfeld N, Su TP, Elman I, Picken L, Malhotra AK, Pickar D (1998) Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach. Synapse 29:142–147

    Article  PubMed  CAS  Google Scholar 

  • Bronson ME, Jiang W, DeRuiter J, Clark CR (1995) A behavioral comparison of Nexus, cathinone, BDB, and MDA. Pharmacol Biochem Behav 51:473–475

    Article  PubMed  CAS  Google Scholar 

  • Brunell SC, Spear LP (2006) Effects of acute ethanol or amphetamine administration on the acoustic startle response and prepulse inhibition in adolescent and adult rats. Psychopharmacology 186:579–586

    Article  PubMed  CAS  Google Scholar 

  • Bubenikova V, Votava M, Horacek J, Palenicek T (2005) Relation of sex and estrous phase to deficits in prepulse inhibition of the startle response induced by ecstasy (MDMA). Behav Pharmacol 16:127–130

    Article  PubMed  CAS  Google Scholar 

  • Carmo H, de Boer D, Remiao F, Carvalho F, dos Reys LA, de Lourdes BM (2004) Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration. JChromatogrB Analyt Technol Biomed Life Sci 811:143–152

    CAS  Google Scholar 

  • Carmo H, Hengstler JG, de Boer D, Ringel M, Remiao F, Carvalho F, Fernandes E, dos Reys LA, Oesch F, de Lourdes BM (2005) Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human. Toxicology 206:75–89

    Article  PubMed  CAS  Google Scholar 

  • Caudevilla-Galligo F, Riba J, Ventura M, Gonzalez D, Farre M, Barbanoj MJ, Bouso JC (2012) 4-Bromo-2,5-dimethoxyphenethylamine (2C-B): presence in the recreational drug market in Spain, pattern of use and subjective effects. J Psychopharmacol 26:1026–1035

    Article  PubMed  Google Scholar 

  • Cole MD, Lea C, Oxley N (2002) 4-Bromo-2,5-dimethoxyphenethylamine (2C-B): a review of the public domain literature. Sci Justice 42:223–224

    Article  PubMed  CAS  Google Scholar 

  • Davis M (1987) Mescaline: excitatory effects on acoustic startle are blocked by serotonin2 antagonists. Psychopharmacol (Berl) 93:286–291

    Article  CAS  Google Scholar 

  • Davis M, Walters JK (1977) Psilocybin: biphasic dose-response effects on the acoustic startle reflex in the rat. Pharmacol Biochem Behav 6:427–431

    Article  PubMed  CAS  Google Scholar 

  • de Boer D, Bosman I (2004) A new trend in drugs-of-abuse; the 2C-series of phenethylamine designer drugs. Pharm World Sci 26:110–113

    Article  PubMed  Google Scholar 

  • de Boer D, Gijzels MJ, Bosman IJ, Maes RA (1999) More data about the new psychoactive drug 2C-B. J Anal Toxicol 23:227–228

    PubMed  Google Scholar 

  • de Boer D, Bosman IJ, Hidvegi E, Manzoni C, Benko AA, dos Reys LJ, Maes RA (2001) Piperazine-like compounds: a new group of designer drugs-of-abuse on the European market. Forensic Sci Int 121:47–56

    Article  PubMed  Google Scholar 

  • Deutch AY, Cameron DS (1992) Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell. Neuroscience 46:49–56

    Article  PubMed  CAS  Google Scholar 

  • Dimpfel W, Spuler M, Borbe HO (1988) Monitoring of the effects of antidepressant drugs in the freely moving rat by radioelectroencephalography (tele-stereo-EEG). Neuropsychobiology 19:116–120

    Article  PubMed  CAS  Google Scholar 

  • Dimpfel W, Spuler M, Nichols DE (1989) Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG). Psychopharmacol (Berl) 98:297–303

    Article  CAS  Google Scholar 

  • EMCDDA (2004) Report on the risk assessment of 2C-I, 2C-T-2 and 2C-T-7 in the framework of the joint action on new synthetic drugs. European monitoring Centre for Drugs and Drug Addiction (EMCDDA)

  • Everson CA, Bergmann BM, Rechtschaffen A (1989a) Sleep deprivation in the rat: III. Total sleep deprivation. Sleep 12:13–21

    PubMed  CAS  Google Scholar 

  • Everson CA, Gilliland MA, Kushida CA, Pilcher JJ, Fang VS, Refetoff S, Bergmann BM, Rechtschaffen A (1989b) Sleep deprivation in the rat: IX. Recover Sleep 12:60–67

    CAS  Google Scholar 

  • Fiserova M, Consolo S, Krsiak M (1999) Chronic morphine induces long-lasting changes in acetylcholine release in rat nucleus accumbens core and shell: an in vivo microdialysis study. Psychopharmacol (Berl) 142:85–94

    Article  CAS  Google Scholar 

  • Fujakova M, Palenicek T, Tyls F, Kubesova A, Brunovsky M, Krajca V, Horacek J (2011) The effect of phenylethylamine hallucinogens on quantitative electronecephalography and behavior in rats. Behav Pharmacol 22:e38

    Google Scholar 

  • Gentry WB, Ghafoor AU, Wessinger WD, Laurenzana EM, Hendrickson HP, Owens SM (2004) (+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration. Pharmacol Biochem Behav 79:751–760

    Article  PubMed  CAS  Google Scholar 

  • Geyer MA (1998) Behavioral studies of hallucinogenic drugs in animals: implications for schizophrenia research. Pharmacopsychiatry 31(Suppl 2):73–79

    Article  PubMed  CAS  Google Scholar 

  • Geyer MA, Light RK, Rose GJ, Petersen LR, Horwitt DD, Adams LM, Hawkins RL (1979) A characteristic effect of hallucinogens on investigatory responding in rats. Psychopharmacol (Berl) 65:35–40

    Article  CAS  Google Scholar 

  • Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001) Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacol (Berl) 156:117–154

    Article  CAS  Google Scholar 

  • Glennon RA, Titeler M, Lyon RA (1988) A preliminary investigation of the psychoactive agent 4-bromo-2,5-dimethoxyphenethylamine: a potential drug of abuse. Pharmacol Biochem Behav 30:597–601

    Article  PubMed  CAS  Google Scholar 

  • Gold LH, Geyer MA, Koob GF (1989) Neurochemical mechanisms involved in behavioral effects of amphetamines and related designer drugs. NIDA Res Monogr 94:101–126

    PubMed  CAS  Google Scholar 

  • Hegadoren KM, Martin-Iverson MT, Baker GB (1995) Comparative behavioural and neurochemical studies with a psychomotor stimulant, an hallucinogen and 3,4-methylenedioxy analogues of amphetamine. Psychopharmacology (Berl) 118:295–304

    Article  CAS  Google Scholar 

  • Huang HH, Bai YM (2011) Persistent psychosis after ingestion of a single tablet of ‘2C-B’. Prog Neuropsychopharmacol Biol Psychiatry 35:293–294

    Article  PubMed  Google Scholar 

  • Jahng JW, Houpt TA, Wessel TC, Chen K, Shih JC, Joh TH (1997) Localization of monoamine oxidase A and B mRNA in the rat brain by in situ hybridization. Synapse 25:30–36

    Article  PubMed  CAS  Google Scholar 

  • Kalgutkar AS, Dalvie DK, Castagnoli N Jr, Taylor TJ (2001) Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors. Chem Res Toxicol 14:1139–1162

    Article  PubMed  CAS  Google Scholar 

  • Kanamori T, Tsujikawa K, Ohmae Y, Iwata YT, Inoue H, Kishi T, Nakahama T, Inouye Y (2005) A study of the metabolism of methamphetamine and 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in isolated rat hepatocytes. Forensic Sci Int 148:131–137

    Article  PubMed  CAS  Google Scholar 

  • Koch M (1999) The neurobiology of startle. Prog Neurobiol 59:107–128

    Article  PubMed  CAS  Google Scholar 

  • Koch M, Schnitzler HU (1997) The acoustic startle response in rats—circuits mediating evocation, inhibition and potentiation. Behav Brain Res 89:35–49

    Article  PubMed  CAS  Google Scholar 

  • Krebs-Thomson K, Geyer MA (1996) The role of 5-HT(1A) receptors in the locomotor-suppressant effects of LSD: WAY-100635 studies of 8-OH-DPAT, DOI and LSD in rats. Behav Pharmacol 7:551–559

    PubMed  CAS  Google Scholar 

  • Krebs-Thomson K, Paulus MP, Geyer MA (1998) Effects of hallucinogens on locomotor and investigatory activity and patterns: influence of 5-HT2A and 5-HT2C receptors. Neuropsychopharmacology 18:339–351

    Article  PubMed  CAS  Google Scholar 

  • Kubesova A, Palenicek T, Votava M, Fujakova M, Tyls F, Sustkova M, Krsiak M (2011) The influence of 5-HT 1A/2A antagonists on changes in ultrasonic vocalization in rats induced by administration of MDMA and 2C-B. Behav Pharmacol 22:e71

    Article  Google Scholar 

  • Lát J (1973) The analysis of habituation. Acta Neurobiol Exp (Wars) 33:771–789

    Google Scholar 

  • Lingford-Hughes A, Nutt D (2003) Neurobiology of addiction and implications for treatment. Br J Psychiatry 182:97–100

    Article  PubMed  Google Scholar 

  • Lisman J, Buzsaki G (2008) A neural coding scheme formed by the combined function of gamma and theta oscillations. Schizophr Bull 34:974–980

    Article  PubMed  Google Scholar 

  • Lobos M, Borges Y, Gonzalez E, Cassels BK (1992) The action of the psychoactive drug 2C-B on isolated rat thoracic aorta. Gen Pharmacol 23:1139–1142

    Article  PubMed  CAS  Google Scholar 

  • Maloney KJ, Cape EG, Gotman J, Jones BE (1997) High-frequency gamma electroencephalogram activity in association with sleep-wake states and spontaneous behaviors in the rat. Neuroscience 76:541–555

    Article  PubMed  CAS  Google Scholar 

  • Marona-Lewicka D, Nichols DE (2007) Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action. Pharmacol Biochem Behav 87:453–461

    Article  PubMed  CAS  Google Scholar 

  • Marona-Lewicka D, Thisted RA, Nichols DE (2005) Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis. Psychopharmacol (Berl) 180:427–435

    Article  CAS  Google Scholar 

  • Masse F, Hascoet M, Bourin M (2007a) Effect of GABAergic ligands on the anxiolytic-like activity of DOI (a 5-HT(2A/2C) agonist) in the four-plate test in mice. Eur Neuropsychopharmacol 17:483–491

    Article  PubMed  CAS  Google Scholar 

  • Masse F, Nic Dhonnchadha BA, Hascoet M, Bourin M (2007b) Anxiolytic-like effect of 5-HT(2) ligands and benzodiazepines co-administration: comparison of two animal models of anxiety (the four-plate test and the elevated plus maze). Behav Brain Res 177:214–226

    Article  PubMed  CAS  Google Scholar 

  • Moya PR, Berg KA, Gutierrez-Hernandez MA, Saez-Briones P, Reyes-Parada M, Cassels BK, Clarke WP (2007) Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. J Pharmacol Exp Ther 321:1054–1061

    Article  PubMed  CAS  Google Scholar 

  • Nichols DE (1986) Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens. J Psychoactive Drugs 18:305–313

    Article  PubMed  CAS  Google Scholar 

  • Palenicek T, Votava M, Bubenikova V, Horacek J (2005) Increased sensitivity to the acute effects of MDMA (“ecstasy”) in female rats. Physiol Behav 86:546–553

    Article  PubMed  CAS  Google Scholar 

  • Palenicek T, Bubenikova V, Votava M, Horacek J (2006) Účinky selektivního antagonisty serotoninového 5-HT2C receptoru SB242084 na lokomoci potkana v animálních modelech psychóz (The effects of selective antagonist of serotonin 5-HT2C receptor SB242084 on rat`s locomotion in animal models of psychosis). Adiktologie 10:16–19

    Google Scholar 

  • Palenicek T, Hlinak Z, Bubenikova-Valesova V, Votava M, Horacek J (2007) An analysis of spontaneous behavior following acute MDMA treatment in male and female rats. Neuro Endocrinol Lett 28:781–788

    PubMed  CAS  Google Scholar 

  • Palenicek T, Balikova M, Bubenikova-Valesova V, Horacek J (2008) Mescaline effects on rat behavior and its time profile in serum and brain tissue after a single subcutaneous dose. Psychopharmacol (Berl) 196:51–62

    Article  CAS  Google Scholar 

  • Palenicek T, Hlinak Z, Bubenikova-Valesova V, Novak T, Horacek J (2010) Sex differences in the effects of N, N-diethyllysergamide (LSD) on behavioural activity and prepulse inhibition. Prog Neuropsychopharmacol Biol Psychiatry 34:588–596

    Article  PubMed  CAS  Google Scholar 

  • Palenicek T, Balikova M, Rohanova M, Novak T, Horacek J, Fujakova M, Hoschl C (2011a) Behavioral, hyperthermic and pharmacokinetic profile of para-methoxymethamphetamine (PMMA) in rats. Pharmacol Biochem Behav 98:130–139

    Article  PubMed  CAS  Google Scholar 

  • Palenicek T, Fujakova M, Brunovsky M, Balikova M, Horacek J, Gorman I, Tyls F, Tislerova B, Sos P, Bubenikova-Valesova V, Hoschl C, Krajca V (2011b) Electroencephalographic spectral and coherence analysis of ketamine in rats: correlation with behavioral effects and pharmacokinetics. Neuropsychobiology 63:202–218

    Article  PubMed  CAS  Google Scholar 

  • Palenicek T, Fujakova M, Tyls F, Brunovsky M, Kubesova A, Horacek J, Krajca V (2011c) Quantitative EEG in animal models of psychosis: the impact of behaviour. Eur Neuropsychopharmacol 21:S317

    Article  Google Scholar 

  • Palenicek, T, Fujakova, M, Tyls, F, Kubesova, A, Brunovsky, M, Horacek, J, and Krajca, V (2011d) The impact of behavior on cortical EEG in rats. Neuroimaging through the lifespan: Brain development and brain diseases from adolescence to senescence—Joint meeting of ISNIP/lSBET/ECNS September 7–10, 2011, University of Heidelberg, Germany, Abstrakt Book: 106

  • Paulus MP, Geyer MA (1992) The effects of MDMA and other methylenedioxy-substituted phenylalkylamines on the structure of rat locomotor activity. Neuropsychopharmacology 7:15–31

    PubMed  CAS  Google Scholar 

  • Paxinos G, Watson C (2003) The rat brain in stereotaxic coordinates, 4th edn. Elsevier, Academic Press, New York

    Google Scholar 

  • Pontieri FE, Tanda G, Di CG (1995) Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the “shell” as compared with the “core” of the rat nucleus accumbens. Proc Natl Acad Sci USA 92:12304–12308

    Article  PubMed  CAS  Google Scholar 

  • Principe JC, Smith JR (1986) Design and implementation of linear phase FIR filters for biological signal processing. IEEE Trans Biomed Eng 33:550–559

    Article  PubMed  CAS  Google Scholar 

  • Rechtschaffen A, Bergmann BM, Gilliland MA, Bauer K (1999) Effects of method, duration, and sleep stage on rebounds from sleep deprivation in the rat. Sleep 22:11–31

    PubMed  CAS  Google Scholar 

  • Roberts AJ, Koob GF (1997) The neurobiology of addiction: an overview. Alcohol Health Res World 21:101–106

    PubMed  CAS  Google Scholar 

  • Rohanova M, Balikova M (2009) Studies on distribution of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry. Leg Med (Tokyo) 11(Suppl 1):S429–S430

    Article  Google Scholar 

  • Rohanova M, Palenicek T, Balikova M (2008) Disposition of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and its metabolite 4-bromo-2-hydroxy-5-methoxyphenethylamine in rats after subcutaneous administration. Toxicol Lett 178:29–36

    Article  PubMed  CAS  Google Scholar 

  • Segura M, Ortuno J, Farre M, McLure JA, Pujadas M, Pizarro N, Llebaria A, Joglar J, Roset PN, Segura J, de la Torre R (2001) 3,4-Dihydroxymethamphetamine (HHMA). A major in vivo 3,4-methylenedioxymethamphetamine (MDMA) metabolite in humans. Chem Res Toxicol 14:1203–1208

    Article  PubMed  CAS  Google Scholar 

  • Shaw JC, O’Connor KP, Ongley OC (1978) EEG coherence as a measure of cerebral functional organization. In: Brazier MB, Petche H (eds) Architectonics of the cerebral cortex. Raven, New York, pp 245–256

    Google Scholar 

  • Shulgin AT, Carter MF (1975) Centrally active phenethylamines. Psychopharmacol Commun 1:93–98

    PubMed  CAS  Google Scholar 

  • Shulgin A, Shulgin A (1991) PIHKAL: a chemical love story. Transform Press, Berkley, CA

    Google Scholar 

  • Smolinske SC, Rastogi R, Schenkel S (2005) Foxy methoxy: a new drug of abuse. J Med Toxicol 1:22–25

    Article  PubMed  Google Scholar 

  • Spanos LJ, Yamamoto BK (1989) Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat. Pharmacol Biochem Behav 32:835–840

    Article  PubMed  CAS  Google Scholar 

  • Sumnall H, Wooding O (2009) Mephedrone—an update on current knowledge. Centre for Public Health, Liverpool John Moores University

    Google Scholar 

  • Swerdlow NR, Braff DL, Geyer MA (2000) Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behav Pharmacol 11:185–204

    Article  PubMed  CAS  Google Scholar 

  • Swerdlow NR, Geyer MA, Braff DL (2001) Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacol (Berl) 156:194–215

    Article  CAS  Google Scholar 

  • Swerdlow NR, Stephany N, Wasserman LC, Talledo J, Shoemaker J, Auerbach PP (2003) Amphetamine effects on prepulse inhibition across-species: replication and parametric extension. Neuropsychopharmacology 28:640–650

    Article  PubMed  CAS  Google Scholar 

  • Sykes EA (1986) Mescaline-induced motor impairment in rats, assessed by two different methods. Life Sci 39:1051–1058

    Article  PubMed  CAS  Google Scholar 

  • Syslova K, Rambousek L, Kuzma M, Najmanova V, Bubenikova-Valesova V, Slamberova R, Kacer P (2011) Monitoring of dopamine and its metabolites in brain microdialysates: method combining freeze-drying with liquid chromatography-tandem mass spectrometry. J Chromatogr A 1218:3382–3391

    Google Scholar 

  • Thatcher RW, Krause PJ, Hrybyk M (1986) Cortico-cortical associations and EEG coherence: a two-compartmental model. Electroencephalogr Clin Neurophysiol 64:123–143

    Article  PubMed  CAS  Google Scholar 

  • Thatcher RW, Walker RA, Giudice S (1987) Human cerebral hemispheres develop at different rates and ages. Science 236:1110–1113

    Article  PubMed  CAS  Google Scholar 

  • Thatcher RW, Biver CJ, North DM (2003) Quantitative EEG and the Frye and Daubert standards of admissibility. Clin Electroencephalogr 34:39–53

    PubMed  Google Scholar 

  • Thorlacius K, Borna C, Personne M (2008) Bromo-dragon fly–life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case. Lakartidningen 105:1199–1200

    PubMed  Google Scholar 

  • Tyls F, Palenicek T, Fujakova M, Kubesova A, Brunovsky M, Krajca V, Horacek J (2011) The effect of tryptamine hallucinogens on quantitative EEG and behavior in rats. Behav Pharmacol 22:e39

    Google Scholar 

  • Varty GB, Walters N, Cohen-Williams M, Carey GJ (2001) Comparison of apomorphine, amphetamine and dizocilpine disruptions of prepulse inhibition in inbred and outbred mice strains. Eur J Pharmacol 424:27–36

    Article  PubMed  CAS  Google Scholar 

  • Vollenweider FX, Vontobel P, Hell D, Leenders KL (1999) 5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man—a PET study with [11C]raclopride. Neuropsychopharmacology 20:424–433

    Article  PubMed  CAS  Google Scholar 

  • Vyazovskiy V, Achermann P, Borbely AA, Tobler I (2004) Interhemispheric coherence of the sleep electroencephalogram in mice with congenital callosal dysgenesis. Neuroscience 124:481–488

    Article  PubMed  CAS  Google Scholar 

  • Vyazovskiy VV, Ruijgrok G, Deboer T, Tobler I (2006) Running wheel accessibility affects the regional electroencephalogram during sleep in mice. Cereb Cortex 16:328–336

    Article  PubMed  Google Scholar 

  • Vyazovskiy VV, Tobler I, Winsky-Sommerer R (2007) Alteration of behavior in mice by muscimol is associated with regional electroencephalogram synchronization. Neuroscience 147:833–841

    Article  PubMed  CAS  Google Scholar 

  • Wecker JR, Ison JR (1986) Effects of motor-activity on the elicitation and modification of the startle reflex in rats. Anim Learn Behav 14:287–292

    Article  Google Scholar 

  • Wishaw IQ, Haun F, Kolb B (1999) Analysis of behavior in laboratory rodents. In: Windhorst U, Johansson H (eds) Modern techniques in neuroscience. Springer, Berlin, Germany, pp 1243–1275

    Chapter  Google Scholar 

  • Youdim MB, Riederer PF (2004) A review of the mechanisms and role of monoamine oxidase inhibitors in Parkinson's disease. Neurology 63:S32–S35

    Article  PubMed  Google Scholar 

  • Young GA (1988) Relationship between amphetamine-induced effects on EEG power spectra and motor activity in rats. Pharmacol Biochem Behav 30:489–492

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This study was supported by the grants IGA MHCR NS 10374, NS 10375, NT 13897, MEYSCR 1M0517, MHCR MZ0PCP2005, MICR VG20122015075 and VG20122015080. We thank Craig Hampson BSc (Hons) for his helpful comments and language correction.

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Páleníček, T., Fujáková, M., Brunovský, M. et al. Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats. Psychopharmacology 225, 75–93 (2013). https://doi.org/10.1007/s00213-012-2797-7

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