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Effects of delay to reinforcement on the choice between cocaine and food in rhesus monkeys

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Abstract

Rationale

Although a delay between behavior and reinforcer has been shown to weaken behavior, little is known about the effects of delay on drug choice.

Objectives

The present study examined effects of delay between lever press and reinforcer presentation on the choice between a drug and non-drug reinforcer and between different drug doses.

Materials and methods

Monkeys (n=4) were allowed to choose 32 times/day between cocaine and four food pellets. The delay between lever press and a preferred dose of cocaine (0.05 mg/kg/injection) was increased systematically from 0 to 240 s, while the delay to food remained at 0 s. A second group of monkeys (n=4) was allowed to choose between 0.05 mg/kg/injection and a lower dose of cocaine (0.025 mg/kg/injection). Next, a delay that resulted in less than 20% choice of 0.05 mg/kg/injection cocaine was selected and delay to the alternative was varied.

Results

Results were similar across groups. The choice of 0.05 mg/kg/injection approximated 100% at 0 delay and decreased to near 0 as delay increased. As the delay to alternative was subsequently increased from 0 to 240 s, choice of 0.05 mg/kg/injection increased, though full cocaine choice was not generally restored. The delay estimated to maintain 50% choice (indifference point) was lower for the cocaine-food choice (mean=64 s) than for the cocaine–cocaine choice (mean=207 s).

Conclusions

This experiment demonstrates that the choice between cocaine and a non-drug or drug alternative can be modified by increasing the interval between behavior and drug injection. Overall, the results are consistent with a temporal discounting model of drug choice.

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References

  • Ainslie GW (1974) Impulse control in pigeons. J Exp Anal Behav 21:485–489

    Article  PubMed  Google Scholar 

  • Ainslie GW (2001) Breakdown of will. Cambridge University Press, Cambridge, England

    Google Scholar 

  • Anderson KG, Woolverton WL (2000) Concurrent variable-interval drug self-administration and the generalized matching law: a drug class comparison. Behav Pharmacol 11:413–420

    PubMed  CAS  Google Scholar 

  • Anderson KG, Woolverton WL (2003) Effects of dose and infusion delay on cocaine self-administration choice in rhesus monkeys. Psychopharmacology 167:424–430

    PubMed  CAS  Google Scholar 

  • Anderson KG, Woolverton WL (2004) Dose and schedule determinants of cocaine choice under concurrent variable-interval schedules in rhesus monkeys. Psychopharmacology 176:274–280

    Article  PubMed  CAS  Google Scholar 

  • Anderson KG, Velkey AJ, Woolverton WL (2002) The generalized matching law as a predictor of choice between cocaine and food in rhesus monkeys. Psychopharmacology 163:319–326

    Article  PubMed  CAS  Google Scholar 

  • Baum WM (1974) On two types of deviation from the matching law: bias and undermatching. J Exp Anal Behav 22:231–242

    Article  PubMed  Google Scholar 

  • Baum WM, Rachlin HC (1969) Choice as time allocation. J Exp Anal Behav 12:861–874

    Article  PubMed  Google Scholar 

  • Beardsley PM, Balster RL (1993) The effects of delay of reinforcement and dose on the self-administration of cocaine and procaine in rhesus monkeys. Drug Alcohol Depend 34:37–43

    Article  PubMed  CAS  Google Scholar 

  • Bickel WK, Marsch LA (2001) Toward a behavioral economic understanding of drug dependence: delay discounting processes. Addiction 96:73–86

    Article  PubMed  CAS  Google Scholar 

  • Carroll ME (1985) Concurrent phencyclidine and saccharin access: presentation of an alternative reinforcer reduces drug intake. J Exp Anal Behav 43:131–144

    Article  PubMed  CAS  Google Scholar 

  • Carroll ME, Carmona GG, May SA (1991) Modifying drug-reinforced behavior by altering the economic conditions of the drug and a non-drug reinforcer. J Exp Anal Behav 56:361–376

    Article  PubMed  CAS  Google Scholar 

  • Chung SH, Herrnstein RJ (1967) Choice and delay of reinforcement. J Exp Anal Behav 10:67–74

    Article  PubMed  Google Scholar 

  • Davison M, McCarthy D (1988) The matching law: a research review. Lawrence Erlbaum, New Jersey

    Google Scholar 

  • Green L, Myerson J (2004) A discounting framework for choice with delayed and probabilistic rewards. Psychol Bull 130:769–792

    Article  PubMed  Google Scholar 

  • Green L, Myerson J, McFadden E (1997) Rate of temporal discounting decreases with amount of reward. Mem Cogn 25:715–723

    CAS  Google Scholar 

  • Higgins ST (1997) The influence of alternative reinforcers on cocaine use and abuse: a brief review. Pharmacol Biochem Behav 57:419–427

    Article  PubMed  CAS  Google Scholar 

  • Kirby KN, Petry NM, Bickel WK (1999) Heroin addicts have higher discounting rates for delayed rewards than non-drug abusing controls. J Exp Psych 128:78–87

    CAS  Google Scholar 

  • Lile JA, Wang Z, Woolverton WL, France JE, Gregg TC, Davies HML, Nader MA (2003) The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics. J Pharmacol Exp Ther 307:356–366

    Article  PubMed  CAS  Google Scholar 

  • Logue AW (1988) Research on self-control: an integrating framework. Behav Brain Sci 11:665–709

    Article  Google Scholar 

  • Madden GJ, Petry NM, Badger GJ, Bickel WK (1997) Impulsive and self-control choices in opioid-dependent patients and non-drug-using control participants: drug and monetary rewards. Exp Clin Psychopharmacol 5:256–262

    Article  PubMed  CAS  Google Scholar 

  • Mazur JE (1987) An adjusting procedure for studying delayed reinforcement. In: Commons ML, Mazur JE, Nevin JA, Rachlin H (eds) Quantitative analyses of behavior, vol 5. The effect of delay and intervening events on reinforcement value. Erlbaum, Hillsdale, New Jersey, pp 55–73

    Google Scholar 

  • Mazur JE (2001) Hyperbolic value addition and general animal models of choice. Psych Rev 108:96–112

    Article  CAS  Google Scholar 

  • Meisch RA, Lemaire GA (1988) Oral self-administration of pentobarbital by rhesus monkeys: relative reinforcing effects under concurrent fixed-ratio schedules. J Exp Anal Behav 50:75–86

    Article  PubMed  CAS  Google Scholar 

  • Nader MA, Woolverton WL (1991) Effects of increasing the magnitude of an alternative reinforcer on drug choice in a discrete-trials choice procedure. Psychopharmacology 105:169–174

    Article  PubMed  CAS  Google Scholar 

  • Nader MA, Woolverton WL (1992) Effects of increasing response requirement on the choice between cocaine and food in rhesus monkeys. Psychopharmacology 108:295–300

    Article  PubMed  CAS  Google Scholar 

  • Petry NM, Casarella T (1999) Excessive discounting of delayed rewards in substance abusers with gambling problems. Drug Alcohol Depend 56:25–32

    Article  PubMed  CAS  Google Scholar 

  • Rachlin H (2000) The science of self-control. Harvard University Press, Cambridge, MA

    Google Scholar 

  • Rachlin H, Green L (1972) Commitment, choice, and self-control. J Exp Anal Behav 17:15–22

    Article  PubMed  Google Scholar 

  • Stretch R, Gerber GJ, Lane E (1976) Cocaine self-injection behaviour under schedules of delayed reinforcement in monkeys. Can J Physiol Pharmacol 54:632–638

    PubMed  CAS  Google Scholar 

  • Tobin H, Logue AW, Chelonis JJ, Ackerman KT, May JG (1996) Self-control in the monkey Macaca fascicularis. Anim Learn Behav 24:168–174

    Google Scholar 

  • Vuchinich RE, Simpson CA (1998) Hyperbolic temporal discounting in social drinkers and problem drinkers. Exp Clin Psychopharmacol 6:292–305

    Article  PubMed  CAS  Google Scholar 

  • Woolverton WL (2003) A novel choice method for studying drugs as punishers. Pharmacol Biochem Behav 76:125–131

    Article  PubMed  CAS  Google Scholar 

  • Woolverton WL, Rowlett JK (1998) Choice maintained by cocaine or food in rhesus monkeys: effects of varying probability of reinforcement. Psychopharmacology 138:102–106

    Article  PubMed  CAS  Google Scholar 

  • Woolverton WL, Wang Z (2004) Relationship between injection duration, transporter occupancy and reinforcing strength of cocaine. Eur J Pharmacol 486:251–257

    Article  PubMed  CAS  Google Scholar 

  • Woolverton WL, Ranaldi R, Wang Z, Ordway G, Paul IA, Petukhov P, Kozikowski A (2002) Reinforcing strength of a novel dopamine transporter ligand: pharmacodynamic and pharmacokinetic mechanisms. J Pharmacol Exp Ther 303:211–217

    Article  CAS  Google Scholar 

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Acknowledgements

This research was supported by National Institute on Drug Abuse grants DA-08731 and DA-15343 (W. L. W.). All procedures were approved by the University of Mississippi Medical Center’s Animal Use and Care Committee and were in accordance with NIH guidelines. We gratefully acknowledge the technical contributions of Mary Cox and Molly Rector.

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Correspondence to William L. Woolverton.

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Woolverton, W.L., Anderso, K.G. Effects of delay to reinforcement on the choice between cocaine and food in rhesus monkeys. Psychopharmacology 186, 99–106 (2006). https://doi.org/10.1007/s00213-006-0355-x

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  • DOI: https://doi.org/10.1007/s00213-006-0355-x

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