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Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women

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Abstract

Summary

Higher serum uric acid (UA) was associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in postmenopausal women. Furthermore, UA suppressed osteoclastogenesis and decreased production of reactive oxygen species in osteoclast precursors, indicating UA may have beneficial effects on bone metabolism as an antioxidant.

Introduction

UA is known to play a physiological role as an antioxidant, and oxidative stress has detrimental effects on bone metabolism. In the present study, we investigated the association of serum UA level with the osteoporosis-related phenotypes and its direct effect on bone-resorbing osteoclasts using in vitro systems.

Methods

This is a large cross-sectional study, including 7,502 healthy postmenopausal women. Bone mineral density (BMD) and serum UA concentrations were obtained from all subjects. Data on bone turnover markers and lateral thoracolumbar radiographs were available for 1,023 and 6,918 subjects, respectively. An in vitro study investigated osteoclastogenesis and reactive oxygen species (ROS) levels according to UA treatment.

Results

After adjusting for multiple confounders, serum UA levels were positively associated with BMD at all sites (all p < 0.001). Compared with the participants in the highest UA quartile, the odds for osteoporosis were 40 % higher in those in the lowest quartile. The serum UA levels were inversely related to both serum C-terminal telopeptide of type I collagen and osteocalcin levels (p < 0.001 and p = 0.004, respectively). Consistently, subjects with vertebral fracture had lower serum UA levels, compared with those without it (p = 0.009). An in vitro study showed that UA decreased osteoclastogenesis in a dose-dependent manner and reduced the production of ROS in osteoclast precursors.

Conclusion

These results provide epidemiological and experimental evidence that serum UA may have a beneficial effect on bone metabolism as an antioxidant in postmenopausal women.

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References

  1. Jin M, Yang F, Yang I, Yin Y, Luo JJ, Wang H, Yang XF (2012) Uric acid, hyperuricemia and vascular diseases. Front Biosci 17:656–669

    Article  CAS  Google Scholar 

  2. Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G (2009) Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med 266:558–570

    Article  PubMed  CAS  Google Scholar 

  3. Feig DI, Kang DH, Johnson RJ (2008) Uric acid and cardiovascular risk. N Engl J Med 359:1811–1821

    Article  PubMed  CAS  Google Scholar 

  4. Choi HK, Ford ES (2007) Prevalence of the metabolic syndrome in individuals with hyperuricemia. Am J Med 120:442–447

    Article  PubMed  Google Scholar 

  5. Becker BF (1993) Towards the physiological function of uric acid. Free Radic Biol Med 14:615–631

    Article  PubMed  CAS  Google Scholar 

  6. Sautin YY, Johnson RJ (2008) Uric acid: the oxidant–antioxidant paradox. Nucleosides Nucleotides Nucleic Acids 27:608–619

    Article  PubMed  CAS  Google Scholar 

  7. Berry CE, Hare JM (2004) Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications. J Physiol 555:589–606

    Article  PubMed  CAS  Google Scholar 

  8. Duan X, Ling F (2008) Is uric acid itself a player or a bystander in the pathophysiology of chronic heart failure? Med Hypotheses 70:578–581

    Article  PubMed  CAS  Google Scholar 

  9. Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, Harrison DG, Hornig B, Drexler H (2002) Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation 106:3073–3078

    Article  PubMed  CAS  Google Scholar 

  10. Chambers DE, Parks DA, Patterson G, Roy R, Mccord JM, Yoshida S, Parmley LF, Downey JM (1985) Xanthine-oxidase as a source of free-radical damage in myocardial ischemia. J Mol Cell Cardiol 17:145–152

    Article  PubMed  CAS  Google Scholar 

  11. Doehner W, Schoene N, Rauchhaus M, Leyva-Leon F, Pavitt DV, Reaveley DA, Schuler G, Coats AJ, Anker SD, Hambrecht R (2002) Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies. Circulation 105:2619–2624

    Article  PubMed  CAS  Google Scholar 

  12. Waring WS, Webb DJ, Maxwell SRJ (2001) Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. J Cardiovasc Pharm 38:365–371

    Article  CAS  Google Scholar 

  13. Bowman GL, Shannon J, Frei B, Kaye JA, Quinn JF (2010) Uric acid as a CNS antioxidant. J Alzheimers Dis 19:1331–1336

    PubMed  CAS  Google Scholar 

  14. Paganoni S, Zhang M, Quiroz Zarate A, Jaffa M, Yu H, Cudkowicz ME, Wills AM (2012) Uric acid levels predict survival in men with amyotrophic lateral sclerosis. J Neurol 259:1923–1928

    Article  PubMed  CAS  Google Scholar 

  15. Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR (1990) Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85:632–639

    Article  PubMed  CAS  Google Scholar 

  16. Ha H, Kwak HB, Lee SW, Jin HM, Kim HM, Kim HH, Lee ZH (2004) Reactive oxygen species mediate RANK signaling in osteoclasts. Exp Cell Res 301:119–127

    Article  PubMed  CAS  Google Scholar 

  17. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ (2004) Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappa B. Biochem Bioph Res Co 314:197–207

    Article  CAS  Google Scholar 

  18. Park BG, Yoo CI, Kim HT, Kwon CH, Kim YK (2005) Role of mitogen-activated protein kinases in hydrogen peroxide-induced cell death in osteoblastic cells. Toxicology 215:115–125

    Article  PubMed  CAS  Google Scholar 

  19. Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, Mecocci P, Senin U, Pacifici R, Cherubini A (2003) Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 88:1523–1527

    Article  PubMed  CAS  Google Scholar 

  20. Sánchez-Rodríguez M, Ruiz-Ramos M, Correa-Muñoz E, Mendoza-Núñez V (2007) Oxidative stress as a risk factor for osteoporosis in elderly Mexicans as characterized by antioxidant enzymes. BMC Musculoskelet Disord 8:124

    Article  PubMed  Google Scholar 

  21. Sontakke AN, Tare RS (2002) A duality in the roles of reactive oxygen species with respect to bone metabolism. Clin Chim Acta 318:145–148

    Article  PubMed  CAS  Google Scholar 

  22. Hall SL, Greendale GA (1998) The relation of dietary vitamin C intake to bone mineral density: results from the PEPI study. Calcif Tissue Int 63:183–189

    Article  PubMed  CAS  Google Scholar 

  23. Melhus H, Michaelsson K, Holmberg L, Wolk A, Ljunghall S (1999) Smoking, antioxidant vitamins, and the risk of hip fracture. J Bone Miner Res 14:129–135

    Article  PubMed  CAS  Google Scholar 

  24. Rao L, Mackinnon E, Josse R, Murray T, Strauss A, Rao A (2007) Lycopene consumption decreases oxidative stress and bone resorption markers in postmenopausal women. Osteoporosis Int 18:109–115

    Article  CAS  Google Scholar 

  25. Mackinnon E, Rao A, Josse R, Rao L (2011) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women. Osteoporosis Int 22:1091–1101

    Article  CAS  Google Scholar 

  26. Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA, Urry ZL, Chambers TJ (2003) A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 112:915–923

    PubMed  CAS  Google Scholar 

  27. Donghui MM (2010) Moderate levels of plasma uric acid could promote fracture healing. Med Hypotheses 75:682

    Article  PubMed  CAS  Google Scholar 

  28. Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31–41

    Article  PubMed  CAS  Google Scholar 

  29. Kiel D (1995) Assessing vertebral fractures. National Osteoporosis Foundation Working Group on Vertebral Fractures. J Bone Miner Res 10:518–523

    PubMed  CAS  Google Scholar 

  30. Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137–1148

    Article  PubMed  CAS  Google Scholar 

  31. Yoneda M, Takatsuki K, Tomita A (1983) Parathyroid function and uric acid metabolism. Nihon Naibunpi Gakkai Zasshi 59:1738–1751

    PubMed  CAS  Google Scholar 

  32. Hui JY, Choi JW, Mount DB, Zhu Y, Zhang Y, Choi HK (2012) The independent association between parathyroid hormone levels and hyperuricemia: a national population study. Arthritis Res Ther 14:R56. doi:10.1186/ar3769

    Article  PubMed  CAS  Google Scholar 

  33. Miller PD (2008) Safety of parathyroid hormone for the treatment of osteoporosis. Curr Osteoporos Rep 6:12–16

    Article  PubMed  Google Scholar 

  34. Takahashi S, Yamamoto T, Moriwaki Y, Tsutsumi Z, Yamakita J, Higashino K (1998) Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout. Metabolism 47:336–338

    Article  PubMed  CAS  Google Scholar 

  35. Vanholder R, Patel S, Hsu CH (1993) Effect of uric acid on plasma levels of 1,25(OH)2D in renal failure. J Am Soc Nephrol 4:1035–1038

    PubMed  CAS  Google Scholar 

  36. Nabipour I, Sambrook PN, Blyth FM, Janu MR, Waite LM, Naganathan V, Handelsman DJ, Le Couteur DG, Cumming RG, Seibel MJ (2011) Serum uric acid is associated with bone health in older men: a cross–sectional population–based study. J Bone Miner Res 26:955–964

    Article  PubMed  CAS  Google Scholar 

  37. Lean JM, Jagger CJ, Kirstein B, Fuller K, Chambers TJ (2005) Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 146:728–735

    Article  PubMed  CAS  Google Scholar 

  38. Hamidi MS, Corey PN, Cheung AM (2012) Effects of vitamin E on bone turnover markers among US postmenopausal women. J Bone Miner Res 27:1368–1380

    Article  PubMed  CAS  Google Scholar 

  39. Leveille SG, LaCroix AZ, Koepsell TD, Beresford SA, Van Belle G, Buchner DM (1997) Dietary vitamin C and bone mineral density in postmenopausal women in Washington State, USA. J Epidemiol Community Health 51:479–485

    Article  PubMed  CAS  Google Scholar 

  40. Jagger CJ, Lean JM, Davies JT, Chambers TJ (2005) Tumor necrosis factor-alpha mediates osteopenia caused by depletion of antioxidants. Endocrinology 146:113–118

    Article  PubMed  CAS  Google Scholar 

  41. Sritara C, Ongphiphadhanakul B, Chailurkit L, Yamwong S, Ratanachaiwong W, Sritara P (2012) Serum uric acid levels in relation to bone-related phenotypes in men and women. J Clin Densitom. doi:10.1016/j.jocd.2012.05.008

    PubMed  Google Scholar 

  42. Makovey J, Macara M, Chen JS, Hayward CS, March L, Seibel MJ, Sambrook PN (2013) Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: a longitudinal study. Bone 52:400–406

    Article  PubMed  CAS  Google Scholar 

  43. Brown JP, Albert C, Nassar BA et al (2009) Bone turnover markers in the management of postmenopausal osteoporosis. Clin Biochem 42:929–942

    Article  PubMed  CAS  Google Scholar 

  44. Shin CS, Kim MJ, Shim SM et al (2012) The prevalence and risk factors of vertebral fractures in Korea. J Bone Miner Metab 30:183–192

    Article  PubMed  Google Scholar 

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Acknowledgments

This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (project no.: A110536) and a grant from the Asan Institute for Life Sciences, Seoul, Republic of Korea (project no.: 2011–523).

Conflicts of interest

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, Seoul, 138-736, Republic of Korea

    S. H. Ahn, S. H. Lee, B.-J. Kim, K.-H. Lim, J.-M. Koh & G. S. Kim

  2. Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 138-736, Republic of Korea

    S. J. Bae, E. H. Kim, H.-K. Kim & J. W. Choe

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  1. S. H. Ahn
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Correspondence to S. H. Lee.

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Ahn, S.H., Lee, S.H., Kim, BJ. et al. Higher serum uric acid is associated with higher bone mass, lower bone turnover, and lower prevalence of vertebral fracture in healthy postmenopausal women. Osteoporos Int 24, 2961–2970 (2013). https://doi.org/10.1007/s00198-013-2377-7

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  • DOI: https://doi.org/10.1007/s00198-013-2377-7

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