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Osteoblastogenesis regulation signals in bone remodeling

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Abstract

Bone remodeling is essential for adult bone homeostasis. The failure of this process often leads to the development of osteoporosis, a present major global health concern. The most important factor that affects normal bone remodeling is the tightly controlled and orchestrated regulation of osteoblasts and osteoclasts. The present review summarized the recent discoveries related to osteoblast regulation from several signals, including transforming growth factor-β, bone morphogenetic proteins, Wnt signal, Notch, Eph–Ephrin interaction, parathyroid hormone/parathyroid hormone-related peptide, and the leptin–serotonin–sympathetic nervous systemic pathway. The awareness of these mechanisms will facilitate further research that explores bone remodeling and osteoporosis. Future investigations on the endogenous regulation of osteoblastogenesis will increase the current knowledge required for the development of potential drug targets in the treatment of osteoporosis.

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Acknowledgements

This work was supported by grants from The Ministry of Science and Technology of China (no. 2011DFA30790, 2010CB945600), grants from the National Natural Science Foundation of China (no. 81190133, 30871435), grants from the Chinese Academy of Sciences (no. XDA01030404, KSCX2-EW-Q-1-07), grant from the Science and Technology Commission of Shanghai Municipality (no. 11QH1401600), and grants from the Shanghai Municipal Education Commission (grant no. J50206, 10SG22).

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  1. The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), 225 South Chongqing Road, Shanghai, 200025, China

    C. Zuo, K. Dai & X. Zhang

  2. Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China

    Y. Huang, K. Dai & X. Zhang

  3. Centre of Orthopaedic Research, School of Surgery and Pathology, University of Western Australia, Perth, Australia

    R. Bajis & M. Sahih

  4. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Y.-P. Li

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  1. C. Zuo
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Correspondence to X. Zhang.

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Zuo, C., Huang, Y., Bajis, R. et al. Osteoblastogenesis regulation signals in bone remodeling. Osteoporos Int 23, 1653–1663 (2012). https://doi.org/10.1007/s00198-012-1909-x

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