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The familiality of pelvic organ prolapse in the Utah Population Database

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International Urogynecology Journal Aims and scope Submit manuscript

Abstract

Introduction and hypothesis

Pelvic organ prolapse (POP) in women is a common condition whose etiology is poorly understood. There is increasing evidence that POP is heritable. The aim of our study was to define and evaluate familial clustering of POP.

Methods

Using a population-based Utah genealogy linked to more than a decade of hospital data, we calculated relative risks (RR) of POP in female relatives of women with POP using age- and birth year-specific rates of POP. We compared the average pairwise relatedness of all POP cases to the population using a measure of genetic distance.

Results

We identified 1,292 women with diagnostic and procedure codes for POP. The RR of POP was significantly elevated in first- and third-degree female relatives (RR 4.15, p < 0.001; RR 1.24, p = 0.05). The average pairwise relatedness for all individuals with POP was significantly higher than expected (p < 0.001).

Conclusions

These results strongly support a significant heritable contribution to POP.

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Conflicts of interest

Supported by grants from the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development R01 HD41163 (PAN) and RO1 HD061821 (LCA and PAN).

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Division of Urogynecology and Reconstructive Pelvic Surgery, University of Utah Health Sciences Center, Salt Lake City, UT, 84132, USA

    Peggy A. Norton

  2. Department of Medicine, Division of Genetic Epidemiology, University of Utah Health Sciences Center, Salt Lake City, UT, 84132, USA

    Kristina Allen-Brady & Lisa A. Cannon-Albright

  3. George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA

    Lisa A. Cannon-Albright

  4. Department of Obstetrics and Gynecology, University of Utah School of Medicine, Rm 2B200, 30 N 1900 East, Salt Lake City, UT, 84132, USA

    Peggy A. Norton

Authors
  1. Peggy A. Norton
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  2. Kristina Allen-Brady
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  3. Lisa A. Cannon-Albright
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Corresponding author

Correspondence to Peggy A. Norton.

Appendix 1

Appendix 1

  • ICD-9 diagnostic codes:

    • All genital prolapse codes (618 series)

  • CPT-4 procedure codes:

    • Colpocleisis (57120)

    • Pessary (57160)

    • Anterior colporrhaphy (57240)

    • Posterior colporrhaphy (57250)

    • Combined anterior and posterior colporrhaphy (57260)

    • Combined anterior and posterior colporrhaphy, with vaginal repair of enterocele (57265)

    • Vaginal repair of enterocele (57268)

    • Abdominal repair of enterocele (57270)

    • Abdominal repair of vaginal vault prolapse, abdominal sacrocolpopexy (57280)

    • Vaginal repair of vaginal vault prolapse, extraperitoneal approach (57282)

    • Vaginal repair of vaginal vault prolapse, intraperitoneal approach (57282)

    • Paravaginal repair (57284)

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Norton, P.A., Allen-Brady, K. & Cannon-Albright, L.A. The familiality of pelvic organ prolapse in the Utah Population Database. Int Urogynecol J 24, 413–418 (2013). https://doi.org/10.1007/s00192-012-1866-0

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  • DOI: https://doi.org/10.1007/s00192-012-1866-0

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