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Risk factors and prognosis of catheter-related bloodstream infection in critically ill patients: a multicenter study

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Abstract

Objective

To assess the risk factors associated with CR-BSI development in critically ill patients with non-tunneled, non-cuffed central venous catheters (CVC) and the prognosis of the episodes of CR-BSI. Design and setting; prospective, observational, multicenter study in nine Spanish Hospitals.

Patients

All subjects admitted to the participating ICUs from October 2004 to June 2005 with a CVC.

Interventions

None.

Measurement and results

Overall, 1,366 patients were enrolled and 2,101 catheters were analyzed. Sixty-six episodes of CR-BSI were diagnosed. The incidence of CR-BSI was significantly higher in CVC compared with peripherically inserted central venous catheters (PICVC) without significant differences among the three locations of CVC. In the multivariate analysis, duration of catheterization and change over a guidewire were the independent variables associated with the development of CR-BSI whereas the use of a PICVC was a protective factor. Excluding PICVC, 1,598 conventional CVC were analyzed. In this subset, duration of catheterization, tracheostomy and change over a guidewire were independent risk factors for CR-BSI. A multivariate analysis of predictors for mortality among 66 patients with CRSI showed that early removal of the catheter was a protective factor and APACHE II score at the admission was a strong determinant of in-hospital mortality.

Conclusions

Peripherically inserted central venous catheters is associated with a lower incidence of CR-BSI in critically ill patients. Exchange over a guidewire of CVC and duration of catheterization are strong contributors to CR-BSI. Our results reinforce the importance of early catheter removal in critically ill patients with CR-BSI.

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Acknowledgment

We are indebted to Dr Aurelio Cayuela for his technical assistance in the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Intensive Care Unit, Hospital Virgen del Rocio, Sevilla, Spain

    Jose Garnacho-Montero, Teresa Aldabó-Pallás, Ana Escoresca-Ortega & Carlos Ortiz-Leyba

  2. Intensive Care Unit, Hospital de la Vall d’Hebron, Barcelona, Spain

    Mercedes Palomar-Martínez

  3. Intensive Care Unit, Hospital Hospital Parc Tauli, Sabadell (Barcelona), Spain

    Jordi Vallés

  4. Infectious Diseases Service, Hospital de la Vall d’Hebron, Barcelona, Spain

    Benito Almirante

  5. Intensive Care Unit, Hospital de la Ribera, Alcira (Valencia), Spain

    Rafael Garcés

  6. Microbiology Service, Hospital Ramon y Cajal, Madrid, Spain

    Fabrio Grill

  7. Infectious Diseases Service, Hospital de Bellvitge, Barcelona, Spain

    Miquel Pujol

  8. Microbiology Service, Hospital Gregorio Marañon, Madrid, Spain

    Cristina Arenas-Giménez

  9. Intensive Care Unit, Hospital Germans Trias y Pujol, Badalona (Barcelona), Spain

    Eduard Mesalles

  10. Microbiology Service, Hospital Virgen Macarena, Sevilla, Spain

    Marina de Cueto

Authors
  1. Jose Garnacho-Montero
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  2. Teresa Aldabó-Pallás
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  11. Ana Escoresca-Ortega
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  12. Marina de Cueto
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  13. Carlos Ortiz-Leyba
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Corresponding author

Correspondence to Jose Garnacho-Montero.

Additional information

Supported by Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Spanish Network for the Research in Infectious Diseases (REIPI C03/14) and Spanish Network for the Research in Infectious Diseases (REIPI RD06/0008).

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Garnacho-Montero, J., Aldabó-Pallás, T., Palomar-Martínez, M. et al. Risk factors and prognosis of catheter-related bloodstream infection in critically ill patients: a multicenter study. Intensive Care Med 34, 2185–2193 (2008). https://doi.org/10.1007/s00134-008-1204-7

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  • DOI: https://doi.org/10.1007/s00134-008-1204-7

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