Skip to main content
Log in

Aprotinin and microvascular thrombosis in cardiac surgery

  • Editorial
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Dixon B, Campbell DJ, Santamaria JD (2008) Elevated pulmonary dead space and coagulation abnormalities suggest lung microvascular thrombosis in patients undergoing cardiac surgery. Intensive Care Med DOI 10.1007/s00134-008-1042-7

  2. Royston D, Bidstrup BP, Taylor KM, Sapsford RN (1987) Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet II:1289–1291

    Article  Google Scholar 

  3. Ranucci M, The European Association of Cardiothoracic Anaesthesiologists (EACTA) (2007) Perioperative haemostasis and coagulation management in cardiac surgery: a European survey. Eur J Anaesthesiol Suppl 24(40):1–13

    Article  Google Scholar 

  4. Levi M, Cromheecke ME, de Jonge E, Prins MH, de Mol BJM, Briët E, Büller HR (1999) Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints. Lancet 354:1940–1947

    Article  PubMed  CAS  Google Scholar 

  5. Mangano DT, Tudor IC, Dietzel C, The Multicenter Study of Perioperative Ischemia Research Group, The Ischemia Research Education Foundation (2006) The risk associated with aprotinin in cardiac surgery. N Engl J Med 354:353–365

    Article  PubMed  CAS  Google Scholar 

  6. Mangano DT, Miao Y, Vuylsteke A, Tudor IC, Juneja R, Filipescu D, Hoeft A, Fontes ML, Hillel Z, Ott E, Titov T, Dietzel C, Levin J, The Multicenter Study of Perioperative Ischemia Research Group, The Ischemia Research and Education Foundation (2007) Mortality associated with aprotinin during 5 years following coronary artery bypass graft surgery. JAMA 297:471–479

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marco Ranucci.

Additional information

This editorial refers to the article available at: http://dx.doi.org/10.1007/s00134-008-1042-7.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ranucci, M. Aprotinin and microvascular thrombosis in cardiac surgery. Intensive Care Med 34, 1175–1176 (2008). https://doi.org/10.1007/s00134-008-1043-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-008-1043-6

Navigation