Abstract
All known cosmic and geological conditions and laws of chemistry and thermodynamics allow that complex organic matter could have formed spontaneously on pristine planet Earth about 4,000 mya. Simple gasses and minerals on the surface and in oceans of the early Earth reacted and were eventually organized in supramolecular aggregates and enveloped cells that evolved into primitive forms of life. Chemical evolution, which preceded all species of extant organisms, is a fact. In this review, we have concentrated on experimental and theoretical research published over the last two decades, which has added a wealth of new details and helped to close gaps in our previous understanding of this multifaceted field. Recent exciting progress in the molecular and genetic analyses of existing life, in particular microorganisms of ancient origin, even supports the possibility that a cellular, self-reproducing common ancestor might be assembled and resurrected in anaerobic cultures at some time in the future. Charles Darwin did not, and indeed, could not, address and specify the earliest phases of life which preceded the Origin of Species. However, in a famous letter, he sketched “a warm little pond with all sorts of… (chemicals, in which) …a protein was chemically formed.” We try to trace the impact of his charming clear-sighted metaphor up to the present time.
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References
Abramov O, Mojzsis SJ (2009) Microbial habitability of the Hadean Earth during the late heavy bombardment. Nature 459:419–422
Bada JL (2001) State-of-art instruments for detecting extraterrestrial life. Proc Natl Acad Sci U S A 98:797–800
Beaulieu JP, PLANET Collaboration (2006) Discovery of a cool planet of 5.5 Earth masses through gravitational microlensing. Nature 439:437–439
Benner SA, Ellington AD (1987) The last ribo-organism. Nature 329:295–296
Bergmann ED, Pullman B (eds) (1972) The purines. Theory and experiment. The Israel Academy of Sciences and Humanities, Jerusalem
Blair NE, Bonner WA (1981) A model for the enantiomeric enrichment of polypeptides on the primitive earth. Orig Life 11:331–335
Böhler C, Nielsen PE, Orgel LE (1995) Template switching between PNA and RNA oligonucleotides. Nature 376:578–581
Bondy SC, Harrington ME (1979) l-Amino acids and d-glucose bind stereospecifically to a colloidal clay. Science 203:1243–1244
Bossard AR, Raulin F, Mourey D, Toupance G (1982) Organic synthesis from reducing models of the atmosphere of the primitive earth with UV light and electric discharges. J Mol Evol 18:173–178
Boussau B, Blanquart S, Necsuela A, Lartillot N, Gouy M (2008) Parallel adaptations to high temperatures in the Archaen eon. Nature 456:942–945
Brandes JA, Boctor NZ, Cody GD, Cooper BA, Hazen RM, Yodor HS (1998) Abiotic nitrogen reduction on the early Earth. Nature 395:365–367
Calvin M (1969) Chemical evolution. Oxford University Press, Oxford
Carroll SB (2001) Chance and necessity: the evolution of morphological complexity and diversity. Nature 409:1102–1109
Cech TR (1987) The chemistry of self-splicing RNA and RNA enzymes. Science 236:1532–1539
Chyba C (1997) A left-handed solar system? Nature 389:234–235
Chyba C, Sagan C (1992) Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: an inventory for the origins of life. Nature 355:125–132
Cleaves HJ, Chalmers JH, Lazcano A, Miller SL, Bada JL (2008) A reassessment of prebiotic organic synthesis in neutral planetary atmospheres. Orig Life Evol Biosph 38:105–115
Cody GD, Boctor NZ, Filley TR, Hazen RM, Scott JH, Sharma A, Yoder HS (2000) Primordial carbonylated iron–sulfur compounds and the synthesis of pyruvate. Science 289:1337–1340
Darwin C (1859) The origin of species by means of natural selection or the preservation of favoured races in the struggle for life. Murray, London
Drobner E, Huber H, Wächtershäuser G, Rose D, Stetter KO (1990) Pyrite formation linked with hydrogen evolution under anaerobic conditions. Nature 346:742–744
de Duve C (1987) Selection by differential molecular survival: a possible mechanism of early chemical evolution. Proc Natl Acad Sci U S A 84:8253–8256
de Duve C (1991) Blueprint for a cell: the nature and origin of life. Neil Patterson, Burlington
Ducluzeau AL, van Lis R, Duval S, Russell MJ, Nitschke W (2009) Was nitric oxide the first deep electron sink? Trends Biochem Sci 34:9–15
Eigen M (1971) Selforganization of matter and the evolution of biological macromolecules. Naturwissenschaften 58:465–523
Eigen M (1981) Darwin und die Molekularbiologie. Angew Chem 93:221–229
Eisner JA (2007) Water vapour and hydrogen in the terrestrial-planet-forming region of a protoplanetary disk. Nature 447:562–564
Engel MH, Macko SA (1997) Isotopic evidence for extraterrestrial non-racemic amino acids in the Murchison meteorite. Nature 389:265–268
Engel MH, Nagy B (1982) Distribution and enantiomeric composition of amino acids in the Murchison meteorite. Nature 296:837–840
Eschenmoser A, Dobler M (1992) Warum pentose- und nicht hexose-Nucleinsäuren? Teil I. Helv Chim Acta 75:218–259
Fegley B, Prinn RG, Hartman H, Watkins GH (1986) Chemical effects of large impacts on the Earth’s primitive atmosphere. Nature 319:305–307
Ferris JP, Ertem G (1993) Montmorillonite catalysis of RNA oligomer formation in aqueous solution. J Am Chem Soc 115:12270–12275
Ferris JP, Hagan WJ (1984) HCN and chemical evolution: the possible role of cyano compounds in prebiotic synthesis. Tetrahedron 40:1093–1120
Ferris JP, Hill AR, Liu R, Orgel LE (1996) Synthesis of long prebiotic oligomers on mineral surfaces. Nature 381:59–61
Fletcher SP, Jagt RBC, Feringa BL (2007) An astrophysically relevant mechanism for amino acid enantiomer enrichment. Chem Commun 2007:2578–2580
Follmann H (1981) Chemie und Biochemie der evolution. Quelle und Meyer, Heidelberg
Follmann H (1982) Deoxyribonucleotides and the emergence of DNA in molecular evolution. Naturwissenschaften 69:75–81
Follmann H (1986) Have deoxyribonucleotides and DNA been among the earliest biomolecules? Adv Space Res 6:33–38
Follmann H (2004) Deoxyribonucleotides: the unusual biochemistry and chemistry of DNA precursors. Chem Soc Rev 33:225–233
Folsome C, Brittain A (1981) Model protocells photochemically reduce carbonate to organic carbon. Nature 291:482–484
Försterling HD, Kuhn H, Tews KH (1972) Computermodell zur Bildung selbstorganisierender Systeme. Angew Chem 84:862–865
Fox SW (1980) Metabolic microspheres. Origins and evolution. Naturwissenschaften 67:378–383
Galtier N, Tourasse N, Gouy M (1999) A non-hyperthermophilic common ancestor to extant life forms. Science 283:220–221
Gaucher EA, Thomson JM, Burgan MF, Benner SA (2003) Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins. Nature 425:285–288
Gaucher EA, Govindarajan S, Ganesh OK (2008) Palaeotemperature trend for Precambrian life inferred from resurrected proteins. Nature 451:704–707
Gesteland RF, Cech TR, Atkins JF (eds) (2006) The RNA world, 3rd edn, chapters 1–3, 7. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
Gil R, Silva FJ, Peretó J, Moya A (2004) Determination of the core of a minimal bacterial gene set. Microbiol Mol Biol Rev 68:518–537
Gilbert W (1986) The RNA world. Nature 319:618
Goesmann F, Rosenbauer H, Roll R, Szopa C, Raulin F, Sternberg R, Israel G, Meierhenrich U, Thiemann W, Munoz-Caro G (2007) COSAC, the cometary sampling and composition experiment. Space Sci Rev 128:257–280
Griffiths G (2007) Cell evolution and the problem of membrane topology. Nat Rev Mol Cell Biol 8:1018–1024
Gutfraind A, Kempf A (2008) Error-reducing structure of the genetic code indicates code origin in non-thermophilic organisms. Orig Life Evol Biosph 38:75–85
Halliday AN (2001) In the beginning. Nature 409:144–145 and references quoted therein
Hargreaves WR, Mulvihill SJ, Deamer DW (1977) Synthesis of phospholipids and membranes in prebiotic conditions. Nature 266:78–80
Hardin G (1950) Darwin and the heterotroph hypothesis. Sci Mon 70:178–179
Hartmann J, Brand MC, Dose K (1981) Formation of specific amino acid sequences during thermal polymerization of amino acids. BioSystems 13:141–147
Hayes JM (1996) The earliest memories of life on Earth. Nature 384:21–22
Hazen RM, Filley TR, Goodfriend GA (2001) Selective adsorption of l- and d-amino acids on calcite: implications for biochemical homochirality. Proc Natl Acad Sci U S A 98:5487–5490
Huber C, Wächtershäuser G (1997) Activated acetic acid by carbon fixation on (Fe, Ni)S under primordial conditions. Science 276:245–247
Huber C, Wächtershäuser G (1998) Peptides by activation of amino acids with CO: implications for the origin of life. Science 281:670–672
Huber C, Wächtershäuser G (2006) Hydroxy and amino acids under possible Hadean, volcanic origin-of-life conditions. Science 314:630–632
Ishikawa K, Sato K, Shima Y, Urabe I, Yomo T (2004) Expression of a cascading genetic network within liposomes. FEBS Lett 576:387–390
Jacobsen SB (2003) How old is planet Earth? Science 300:1513–1514
Janda M, Morvova M, Machala Z, Morva I (2008) Study of plasma induced chemistry by DC discharges in CO2/N2/H2O mixtures above a water surface. Orig Life Evol Biosph 38:23–35
Johnson AP, Cleaves HJ, Dworkin JP, Glavin DP, Lazcano A, Bada JL (2008) The Miller volcanic spark discharge experiment. Science 322:404
Joyce GF (1998) Nucleic acid enzymes: playing with a fuller deck. Proc Natl Acad Sci U S A 95:5845–5847
Jungck JR, Fox SW (1973) Synthesis of oligonucleotides by proteinoid microspheres acting on ATP. Naturwissenschaften 60:425–427
Kasting JF (1993) Earth’s early atmosphere. Science 259:920–926
Keefe AD, Miller SL (1995) Are polyphosphates or phosphate esters prebiotic reagents? J Mol Evol 41:693–702
Keefe AD, Miller SL, McDonald G, Bada J (1995a) Investigation of the prebiotic synthesis of amino acids and RNA bases from CO2 using FeS/H2S as a reducing agent. Proc Natl Acad Sci U S A 92:11904–11906
Keefe AD, Newton GL, Miller SL (1995b) A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A. Nature 373:683–685
Kleinkauf H, van Liempt H, Palissa H, von Döhren H (1992) Biosynthese von Peptiden: Ein nichtribosomales system. Naturwissenschaften 79:153–162
Krishnamurthy R, Pitsch S, Minton M, Miculka C, Windhab N, Eschenmoser A (1996) Pyranosyl-RNA. Angew Chem 108:1619–1623
Kuhn H (1972) Selbstorganisation molekularer Systeme und die evolution des genetischen Apparates. Angew Chem 84:838–862
Kuhn H (1976) Model considerations for the origin of life. Naturwissenschaften 63:68–80
Kuhn H, Waser J (1981) Molekulare Selbstorganisation und Ursprung des Lebens. Angew Chem 93:495–515
Kuhn H, Försterling HD, Waldeck DH (2009) Principles of physical chemistry, 2nd edn, chapter 29: Origin of life - matter carrying information. Wiley-VCH, Weinheim
Kutschera U (2009) Charles Darwin’s Origin of Species, directional selection, and the evolutionary sciences today. Naturwissenschaften doi:10.1007/s00114-009-0603-0
Kutschera U, Niklas KJ (2004) The modern theory of biological evolution: an expanded synthesis. Naturwissenschaften 91:255–276
Kvenvolden KA (1974) Geochemistry and the origin of life. Benchmark papers in geology, vol. 14. Dowden, Hutchinson & Ross, Stroudsburg
Laerdahl JK, Wesendrup R, Schwerdtfeger P (2000) d- or l-Alanine: that is the question. ChemPhysChem 2000:60–62
Lahav N, White D, Chang S (1978) Peptide formation in the prebiotic era. Science 201:67–69
Lazcano A, Miller SL (1994) How long did it take for life to begin and evolve to cyanoabacteria? J Mol Evol 39:546–554
Lee DH, Granja JR, Martinez JA, Severin K, Ghadiri MR (1996) A self-replicating peptide. Nature 382:525–528
Leman L, Orgel LE, Ghadiri MR (2004) Carbonyl sulfide-mediated prebiotic formation of peptides. Science 306:283–286
Leman LJ, Orgel LE, Ghadiri MR (2006) Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide. J Am Chem Soc 128:20–21
Lemmon RM (1970) Chemical evolution. Chem Rev 70:95–109
Löb W (1913) Über das Verhalten des Formamids unter der Wirkung der stillen Entladung. Ein Beitrag zur Frage der Stickstoff-Assimilation. Chem Ber 46:684–697
Lohrmann R, Bridson PK, Orgel LE (1980) Efficient metal-ion catalysed template-directed oligonucleotide synthesis. Science 208:1464–1465
Mansy SS, Schrum JP, Krishnamurty M, Tobé S, Treco DA, Szostak JW (2008) Template-directed synthesis of a genetic polymer in a model protocell. Nature 454:122–125
Mar A, Oró J (1991) Synthesis of the coenzymes ADP-glucose, GDP-glucose, and CDP-ethanolamine under primitive earth conditions. J Mol Evol 32:201–210
McLoughlin N, Brasier MD, Wacey D, Green OR, Perry R (2007) On biogenecity criteria for endolithic microborings on early Earth and beyond. Astrobiology 7:10–26
Meierhenrich U, Munoz Caro G, Bredehöft JH, Jessberger LK, Thiemann W (2004) Identification of diamino acids in the Murchison meteorite. Proc Natl Acad Sci U S A 101:9182–9186
Miescher F (1871) Über die chemische Zusammensetzung der Eiterzellen. Hoppe-Seylers Medizinische-Chemischen Untersuchungen 4:441–460
Millar TJ (2004) Organic molecules in the interstellar medium. In: Ehrenfreund P et al (eds) Astrobiology: future perspectives. Kluwer Academic, The Netherlands, pp 17–31
Miller SL (1953) A production of amino acids under possible primitive earth conditions. Science 117:528–529
Miller SL (1955) Production of some organic compounds under possible primitive earth conditions. J Am Chem Soc 77:2351–2361
Miller SL, Lazcano A (1995) The origin of life—did it occur at high temperature? J Mol Evol 41:689–692
Miller SL, Urey HC (1959) Organic compound synthesis on the primitive earth. Science 130:245–251
Mills DR, Petersen RL, Spiegelman S (1967) An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule. Proc Natl Acad Sci U S A 59:217–224
Miyakawa S, Yamanashi H, Kobayashi K, Cleaves HJ, Miller SL (2002) Prebiotic synthesis from CO atmospheres: iImplications for the origin of life. Proc Natl Acad Sci U S A 99:14628–14631
Monnard PA, Oberholzer T, Luisi PL (1997) Entrapment of nucleic acids in liposomes. Biochim Biophys Acta 1329:39–50
Monod J (1970) Le hasard et la nécessité. Editions du Seuil, Paris; Zufall und Notwendigkeit (1971) Piper-Verlag München; Chance and necessity (1971) Knopf, New York
Munoz Caro GM, Meierhenrich U, Schutte WA, Barbier B, Arcones Segovia A, Rosenbauer H, Thiemann W, Brack A, Greenberg JM (2002) Amino acids from ultraviolet irradiation of interstellar ice analogues. Nature 416:403–406
Mushegian AR, Koonin EV (1996) A minimal gene set for cellular life derived by comparison of complete bacterial genomes. Proc Natl Acad Sci U S A 93:10268–10273
Nelson KE, Levy M, Miller SL (2000) Peptide nucleic acids rather than RNA may have been the first genetic molecule. Proc Natl Acad Sci U S A 97:3868–3871
Nissen P, Hansen J, Ban N, Moore PB, Steitz TA (2000) The structural basis of ribosome activity in peptide bond synthesis. Science 289:920–930
Nomura M, Erdmann V (1970) Reconstitution of ribosomal subunits from dissociated molecular components. Nature 228:744–748
Oberbeck V, Fogleman G (1989) Impacts and the origin of life. Nature 339:434
Okihana H, Egami F (1979) Polymers produced by heating an amino acid mixture in sea water enriched with transition elements. Orig Life 9:171–180
Oparin AI (1924) Proiskhozdenie zhizny (Origin of Life). Izd. Moskovski Rabochii, Moscow
Oparin AI (1936) Origin of life (Moscow, in Russian); (1938, Macmillan, New York, in English)
Oparin AI (1957) Die Entstehung des Lebens auf der Erde. VEB Verlag der Wissenschaften, Berlin
Orgel LE, Crick HC (1980) Selfish DNA: the ultimate parasite. Nature 284:604–607
Otting G, Billeter M, Wüthrich K, Roth HJ, Leumann C, Eschenmoser A (1993) Warum pentose- und nicht hexose-Nucleinsäuren? Teil IV. Helv Chim Acta 76:2701–2755
Paecht-Horowitz M (1976) Clays as possible catalysts for peptide formation in the prebiotic era. Orig Life 7:369–381
Paecht-Horowitz M, Eirich FR (1988) The polymerization of amino acid adenylates on sodium montmorillonite with preadsorbed polypeptides. Orig Life Evol Biosph 18:359–387
Pasek M (2008) Rethinking early Earth phosphorus geochemistry. Proc Natl Acad Sci U S A 105:853–858
Pasek M, Lauretta D (2008) Extraterrestrial flux of potentially prebiotic C, N, and P to the early earth. Orig Life Evol Biosph 38:5–21
Penzlin H (2009) The riddle of “life”, a biologist’s critical view. Naturwissenschaften 96:1–23
Pfeil E, Ruckert H (1961) Die Bildung von Zuckern aus Formaldehyd unter der Einwirkung von Laugen. Liebigs Ann Chem 641:121–131
Pflug HD, Jaeschke-Boyer H (1979) Combined structural and chemical analysis of 3,800-Myr-old microfossils. Nature 280:483–486
Piccirilli JA (1995) RNA seeks its maker. Nature 376:548–549
Pizzarello S, Weber AL (2004) Prebiotic amino acids as asymmetric catalysts. Science 303:1151
Plankensteiner K, Reiner H, Rode BM (2006) Amino acids on the rampant primordial earth: electric discharges and the hot salty ocean. Mol Divers 10:3–7
Porco CC, Baker E, Barbara J, Beurle K, Brahic A, Burns JA, Charnoz S, Cooper N, Dawson DD, Del Genio AD, Denk T, Dones L, Dyunida U, Evans MW, Fussner S, Giese B, Grazier K, Helfenstein P, Ingersoll AP, Jacobson RA, Johnson TV, McEwen A, Murray CD, Neukum G, Owen WM, Perry J, Roatsch T, Spitale J, Squyres S, Thomas P, Tiscareno M, Turtle E, Vasavada AR, Veverka J, Wagner R, West R (2005) Imaging of Titan from the Cassini spacecraft. Nature 434:159–168
Powner MW, Gerland B, Sutherland JD (2009) Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature 459:239–242
Rajamani S, Vlassov A, Benner S, Coombs A, Olasagasti F, Deamer D (2008) Lipid-assisted synthesis of RNA-like polymers from mononucleotides. Orig Life Evol Biosph 38:57–74
Reiner H, Plankensteiner K, Fitz D, Rode BM (2006) The possible influence of L-histidine on the origin of the first peptides on the primordial earth. Chem Biodivers 3:611–621
Ricardo A, Carrigan MA, Olcott AN, Benner SA (2004) Borate minerals stabilize ribose. Science 303:196
Robertson MP, Miller SL (1995) An efficient prebiotic synthesis of cytosine and uracil. Nature 375:772–774
Rossmann MG, Moras D, Olsen KW (1974) Chemical and biological evolution of a nucleotide-binding protein. Nature 250:194–199
Rode BM (1999) Peptides and the origin of life. Peptides 20:773–786
Rode BM, Schwendinger MG (1990) Copper-catalyzed amino acid condensation in water—a simple way of prebiotic peptide formation. Orig Life Evol Biosph 20:401–410
Rohlfing DL (1976) Thermal polyamino acid synthesis at less than 100°C. Science 193:68–70
Russell MJ, Daniel RM, Hall AJ, Sherringham JA (1994) A hydrothermically precipitated iron sulphide membrane as a first step towards life. J Mol Evol 39:231–243
Sagan C, Chyba C (1997) The early faint sun paradox: organic shielding of ultraviolet-labile greenhouse gases. Science 276:1217–1221
Schidlowski M (1988) A 3,800-million-year isotopic record of life from carbon in sedimentary rocks. Nature 333:313–318
Schoning K, Scholz P, Guntha S, Wu X, Krishnamurthy R, Eschenmoser A (2000) Chemical etiology of nucleic acid structure: the α-threofuranosyl-(3′–2′)oligonucleotide system. Science 290:1347–1351
Schopf JW (1993) Microfossils of the early Archaen apex chert: new evidence of the antiquity of life. Science 260:640–646
Schopf JW (1999) Cradle of life. Earth’s earliest fossils. Princeton University Press, Princeton
Schrauzer GN, Strampach N, Hui LN, Palmer MR, Salehi J (1983) Nitrogen photoreduction on desert sands under sterile conditions. Proc Natl Acad Sci U S A 80:3873–3876
Schwendinger MG, Rode BM (1992) Investigations on the mechanism of salt-induced peptide formation. Orig Life Evol Biosph 22:349–359
Seel F, Schinnerling F (1978) Die Cyanat-induzierte Umwandlung von Calciumhydrogen-phosphat in Calciumdiphosphat—eine präbiotische Schlüsselreaktion? Z Naturforsch 33b:373–376
Seel F, Klos KP, Schuh J (1985) Hydrothermale Kondensation von Magnesiumhydrogen-phosphaten zu Magnesiumdiphosphaten. Naturwissenschaften 72:658
Sleep NH, Zahnle KJ, Kasting JF, Morowitz HJ (1989) Annihilation of ecosystems by asteroid impacts on the early Earth. Nature 342:139–142
Spaargaren DH (1985) Origin of life: oceanic genesis, panspermia, or Darwin’s warm little pond? Experientia 41:719–727
Strobel SA, Doudna JA (1997) RNA seeing double: close-packing of helices in RNA tertiary structure. Trends Biochem Sci 22:262–265
Stubbe JA, Ge J, Yee CS (2001) The evolution of ribonucleotide reduction revisited. Trends Biochem Sci 26:93–99
Thiemann W (ed) (1981) Generation and amplification of chirality in chemical systems. Origins of life, vol 11. Reidel, Dordrecht
Tian F, Toon OB, Pavlov AA, de Sterck H (2005) A hydrogen-rich early earth atmosphere. Science 308:1014–1017
Tranter GE (1985) Parity-violating differences of chiral minerals and the origin of biomoleculae homochirality. Nature 318:172–173 (1986) Paritätsverletzung: Ursache der biomolekularen Chiralität. Nachr Chem Tech Lab 34:867–870
Tranter GE (1986) Preferential stabilization of the d-sugar series by the parity-violating weak interactions. J Chem Soc Chem Comm 1986:60–61
Unrau PJ, Bartel DP (1998) RNA-catalyzed nucleotide synthesis. Nature 395:260–263
Urey HC (1952) On the early chemical history of the earth and the origin of life. Proc Natl Acad Sci U S A 38:351–363
Usher DA (1977) Early chemical evolution of nucleic acids. Science 196:311–313
Voet AB, Schwartz AW (1983) Prebiotic adenine synthesis from HCN. Evidence for a newly discovered major pathway. Bioorg Chem 12:8–17
Wächtershäuser G (1988) Pyrite formation, the first energy source for life: a hypothesis. Syst Appl Microbiol 10:207–210
Wächtershäuser G (2000) Life as we don’t know it. Science 289:1307–1308
Waldrop MM (1989) Did life really start out in an RNA world? Science 246:1248–1249
Walsh C (2001) Enabling the chemistry of life. Nature 409:226–231
Weber AL (1992) Prebiotic sugar synthesis: hexose and hydroxy acid synthesis from glyceraldehyde catalyzed by iron(III) hydroxide oxide. J Mol Evol 35:1–6
Weber AL, Miller SL (1981) Reasons for the occurrence of the twenty coded protein amino acids. J Mol Evol 17:273–284
Weber P, Greenberg JM (1985) Can spores survive in interstellar space? Nature 316:403–407
Whitfield J (2004) Born in a watery commune. Nature 427:674–676
Woese CR (1998) The universal ancestor. Proc Natl Acad Sci U S A 95:6854–6859
Woese CR (2000) Interpreting the universal phylogenetic tree. Proc Natl Acad Sci U S A 97:8392–8396
Wong JT (1975) A co-evolution theory of the genetic code. Proc Natl Acad Sci U S A 72:1909–1912
Wiechert UH (2002) Earth’s early atmosphere. Science 298:2341–2342
Yamagata Y, Watanabe H, Saito M, Namba T (1991) Volcanic production of polyphosphates and its relevance to prebiotic evolution. Nature 352:516–519
Zhang L, Peritz A, Meggers E (2005) A simple glycol nucleic acid. J Am Chem Soc 127:4174–4175
Zuckerman B (1977) Interstellar molecules. Nature 268:491–495
Acknowledgements
Vivid discussions with colleagues and friends, in particular Horst-Dieter Försterling, Peter Kaiser, Hans Kuhn, Ulrich Kutschera, Stanley Miller (deceased; La Jolla, CA, USA), Klaus-Heinrich Röhm, and Günter Wächtershäuser are greatly appreciated. The students attending summer academies on evolution at La Villa and Alpbach (Tyrol), sponsored by Studienstiftung, contributed many critical questions and stimulating ideas.
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This contribution is part of the Special Issue “Beyond the Origin: Charles Darwin and modern biology”. Guest editor: U. Kutschera (see Kutschera 2009).
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Follmann, H., Brownson, C. Darwin’s warm little pond revisited: from molecules to the origin of life. Naturwissenschaften 96, 1265–1292 (2009). https://doi.org/10.1007/s00114-009-0602-1
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DOI: https://doi.org/10.1007/s00114-009-0602-1