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Zementaugmentation bei osteoporotischen Wirbelkompressionsfrakturen

Cement augmentation for osteoporotic compression fractures

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Zusammenfassung

Qualitativ hochwertige evidenzbasierte Studien haben wesentliche Fragen zur weit verbreiteten Anwendung der Vertebroplastie zur Behandlung von osteopenen Insuffizienzfrakturen von Wirbelkörpern aufgeworfen. Weitere Studien verschieben gar die Beweislast für interventionelle Verfahren, beispielsweise für die Ballonkyphoplastie. Um ihre Relevanz zu sichern, werden neue prospektive klinische Studien möglicherweise Placeboarme in Betracht ziehen müssen.

Abstract

High-quality evidence has raised significant questions on the widespread use of vertebroplasty in the treatment of osteopenic vertebral insufficiency fractures. Further research is shifting the burden of proof on procedures such as balloon kyphoplasty and other interventions. New prospective clinical trials may need to consider including sham arms to enhance their relevance.

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Literatur

  1. Buchbinder R, Osborne RH, Ebeling PR et al (2009) A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med 361(6):557–568

    Article  PubMed  CAS  Google Scholar 

  2. Kallmes DF, Comstock BA, Heagerty PJ et al (2009) A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 361(6):569–579. Erratum in: N Engl J Med (2012) 366(10):970

    Google Scholar 

  3. Wardlaw D, Cummings SR, Van Meirhaeghe J et al (2009) Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture: a randomised controlled trial. Lancet 373(9668):1016–1024

    Article  PubMed  Google Scholar 

  4. Bono CM, Heggeness M, Mick C et al (2010) North American Spine Society: Newly released vertebroplasty randomized controlled trials: a tale of two trials. Spine J 10(3):238–240

    Article  PubMed  Google Scholar 

  5. Buchbinder R, Kallmes DF (2010) Vertebroplasty: when randomized placebo-controlled trial results clash with common belief. Spine J 10(3):241–243

    Article  PubMed  Google Scholar 

  6. Buchbinder R, Kallmes D, Glasziou P (2010) Vertebroplasty versus conservative treatment for vertebral fractures. Lancet 376(9758):2070–2071 (author reply 2071–2072) (Effectiveness of vertebroplasty using individual patient data from two randomised placebo controlled trials: meta-analysis)

    Google Scholar 

  7. Khosla A, Diehn FE, Rad AE, Kallmes DF (2012) Neither subendplate cement deposition nor cement leakage into the disk space during vertebroplasty significantly affects patient outcomes. Radiology 264(1):180–186

    Article  PubMed  Google Scholar 

  8. Luetmer MT, Bartholmai BJ, Rad AE, Kallmes DF (2011) Asymptomatic and unrecognized cement pulmonary embolism commonly occurs with vertebroplasty. AJNR Am J Neuroradiol 32(4):654–657

    Article  PubMed  CAS  Google Scholar 

  9. McDonald RJ, Achenbach SJ, Atkinson EJ et al (2011) Mortality in the vertebroplasty population. AJNR Am J Neuroradiol 32(10):1818–1823

    Article  PubMed  CAS  Google Scholar 

  10. Boonen S, Van Meirhaeghe J, Bastian L et al (2011) Balloon kyphoplasty for the treatment of acute vertebral compression fractures: 2-year results from a randomized trial. J Bone Miner Res 26(7):1627–1637 doi:10.1002/jbmr.364

    Article  PubMed  Google Scholar 

  11. Klazen CA, Lohle PN, Vries J de et al (2010) Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet 376(9746):1085–1092

    Article  PubMed  Google Scholar 

  12. Buchbinder R, Osborne RH, Kallmes D (2009) Vertebroplasty appears no better than placebo for painful osteoporotic spinal fractures, and has potential to cause harm. Med J Aust 191(9):476–477

    PubMed  Google Scholar 

  13. Chen YJ, Tan TS, Chen WH et al (2006) Intradural cement leakage. A devastatingly rare complication of vertebroplasty. Spine 31:E379–E382

    Article  PubMed  Google Scholar 

  14. Kunz R, Ollenschläger G, Raspe H et al. (2000) Lehrbuch Evidenzbasierte Medizin in Klinik und Praxis. Deutscher Ärzte-Verlag, Köln

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Authors and Affiliations

  1. Orthopedic Surgery and Sports Medicine, Neurological Surgery, University of Washington Medical Center, University of Washington, 1959 NE Pacific St., 98195, Seattle, WA, USA

    M.J. Lee M.D.

  2. Radiology, Orthopedic Surgery and Sports Medicine, Harborview Medical Center, University of Washington, Seattle, WA, USA

    J.G. Jarvik M.D., M.P.H.

Authors
  1. M.J. Lee M.D.
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  2. J.G. Jarvik M.D., M.P.H.
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Correspondence to M.J. Lee M.D..

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The English full-text version of this article is available at SpringerLink (under supplemental).

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Lee, M., Jarvik, J. Zementaugmentation bei osteoporotischen Wirbelkompressionsfrakturen. Unfallchirurg 115, 1066–1069 (2012). https://doi.org/10.1007/s00113-012-2307-8

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  • DOI: https://doi.org/10.1007/s00113-012-2307-8

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