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Autoreaktive Urtikaria und Autoimmunurtikaria

Autoreactive urticaria and autoimmune urticaria

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Zusammenfassung

Die autoreaktive Urtikaria (ArU) ist eine Form der chronischen Urtikaria (CU), deren Symptome durch mastzellaktivierende Serumbestandteile verursacht werden. Sie lässt sich mit Hilfe des autologen Serumtests einfach, rasch und sicher diagnostizieren. Bei einem Teil der ArU-Patienten sind funktionelle Autoantikörper gegen IgE oder dessen Rezeptor FcεRI und damit eine Autoimmunurtikaria (AiU) nachweisbar. ArU- und AiU-Patienten weisen klinische und laborchemische Unterschiede zu anderen CU-Patienten auf.

Abstract

Symptoms in patients with autoreactive urticaria (ArU), a sub-form of chronic urticaria (CU), are caused by circulating histamine−releasing signals. ArU patients are readily identified by the autologous serum skin test, in which they exhibit inflammatory reactions to their serum after intracutaneous injection. CU patients who also exhibit functional autoantibodies against IgE and/or its high affinity receptor FcεRI are thought to suffer from autoimmune urticaria (Aiu). ArU and AiU are pathogenetically and clinically different from other sub-forms of CU.

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Notes

  1. Dr. A. Kromminga, Labor Prof. Arndt & Partner, Lademannbogen 61, 22339 Hamburg, info@labor-arndt-partner.de.

Literatur

  1. Asero R, Tedeschi A, Lorini M et al. (2001) Chronic urticaria: novel clinical and serological aspects. Clin Exp Allergy 31:1105–1110

    Article  PubMed  Google Scholar 

  2. Bakos N, Hillander M (2003) Comparison of chronic autoimmune urticaria with chronic idiopathic urticaria. Int J Dermatol 42:613–615

    Article  PubMed  Google Scholar 

  3. Di Gioacchino M, Di Stefano F, Cavallucci E et al. (2003) Treatment of chronic idiopathic urticaria and positive autologous serum skin test with cyclosporin: clinical and immunological evaluation. Allergy Asthma Proc 24:285–290

    PubMed  Google Scholar 

  4. Fagiolo U, Kricek F, Ruf C et al. (2000) Effects of complement inactivation and IgG depletion on skin reactivity to autologous serum in chronic idiopathic urticaria. J Allergy Clin Immunol 106:567–572

    Article  PubMed  Google Scholar 

  5. Fiebiger E, Hammerschmid F, Stingl G, Maurer D (1998) Anti-FcεRIalpha autoantibodies in autoimmune-mediated disorders. J Clin Invest 101:243–251

    PubMed  Google Scholar 

  6. Fiebiger E, Maurer D, Holub H et al. (1995) Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients? J Clin Invest 96:2606–2612

    PubMed  Google Scholar 

  7. Greaves M (2002) Autoimmune urticaria. Clin Rev Allergy Immunol 23:171–183

    Article  PubMed  Google Scholar 

  8. Grattan CEH, Francis DM, Slater NGP et al. (1992) Plasmapharesis for severe, unremitting, chronic urticaria. Lancet 339:1078–1079

    Article  PubMed  Google Scholar 

  9. Grattan CEH, O’Donnell BFO, Francis DM et al. (2000) Randomized double-blind study of cyclosporin in chronic „idiopthic“ urticaria. Br J Dermatol 143:365–372

    Article  PubMed  Google Scholar 

  10. Hide M, Francis DM, Grattan CEH et al. (1993) Autoantibodies against the high affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 328:1599–1604

    Article  PubMed  Google Scholar 

  11. Hidvegi B, Nagy E, Szabo T et al. (2003) Correlation between T-Cell and mast cell activity in patients with chronic urticaria. Int Arch Allergy Immunol 132:177–182

    Article  PubMed  Google Scholar 

  12. Horn MP, Gerster T, Ochsensberger B et al. (1999) Human anti-FcεRIalpha autoantibodies isolated from healthy donors cross-react with tetanus toxoid. Eur J Immunol 29:1139–1148

    Article  PubMed  Google Scholar 

  13. Kikuchi Y, Kaplan AP (2001) Mechanisms of autoimmune activation of basophils in chronic urticaria. J Allergy Clin Immunol 107:1056–1062

    Article  PubMed  Google Scholar 

  14. Lee KH, Kim JY, Kang DS et al. (2002) Increased expression of endothelial cell adhesion molecules due to mediator release from human foreskin mast cells stimulated by autoantibodies in chronic urticaria sera. J Invest Dermatol 118:658–663

    Article  PubMed  Google Scholar 

  15. Malmros H (1946) Autoserumtest. Nordisk Med 29:150–151

    Google Scholar 

  16. Marone G, Spadaro G, Palumbo C, Condorelli G (1999) The anti-IgE/anti-FcεRIalpha network in allergic and autoimmune diseases. Clin Exp Allergy 29:17–27

    Article  Google Scholar 

  17. Maurer M (2003) Chronic urticaria—new diagnostic findings and therapeutic implications. JEADV 17:10A

    Google Scholar 

  18. Nettis E, Dambra P, D’Oronzio L et al. (2002) Reactivity to autologous serum skin test and clinical features in chronic idiopathic urticaria. Clin Dermatol 27:29–31

    Article  Google Scholar 

  19. Niimi N, Francis DM, Kermani F et al. (1996) Dermal mast cell activation by autoantibodies against the high affinity IgE receptor in chronic urticaria. J Invest Dermatol 106:1001–1006

    PubMed  Google Scholar 

  20. O’Donnell BF, Barr RM, Kobza-Black A et al. (1998) Intravenous immunoglobulin in autoimmune chronic urticaria. Br J Dermatol 138:101–106

    Article  PubMed  Google Scholar 

  21. Piconi S, Trabattoni D, Iemoli E et al. (2002) Immune profiles of patients with chronic idiopathic urticaria. Int Arch Allergy Immunol 128:59–66

    Article  PubMed  Google Scholar 

  22. Sabroe RA, Fiebiger E, Francis DM et al. (2002) Classification of anti-FcεRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol 110:492–499

    Article  PubMed  Google Scholar 

  23. Sabroe RA, Francis DM, Barr RM et al. (1998) Anti-FcεRI autoantibodies and basophil histamine releasability in chronic urticaria. J Allergy Clin Immunol 102:651–658

    PubMed  Google Scholar 

  24. Sabroe RA, Grattan CEH, Francis DM et al. (1999) The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria. Br J Dermatol 140:446–452

    Article  PubMed  Google Scholar 

  25. Sabroe RA, Seed PT, Francis DM et al. (1999) Chronic idiopathic urticaria: comparison of the clinical features of patients with and without anti-FcεRI or anti-IgE autoantibodies. J Am Acad Dermatol 40:443–450

    PubMed  Google Scholar 

  26. Tanus T, Atkins PC, Zweiman B (1996) Comparison of serum histamine-releasing activity and clinical manifestations in chronic idiopathic urticaria. Clin Diag Lab Immunol 3:135–137

    CAS  Google Scholar 

  27. Tedeschi A, Airaghi L, Lorini M, Asero R (2003) Chronic urticaria: a role for newer immunomodulatory drugs? Am J Clin Dermatol 4:297–305

    PubMed  Google Scholar 

  28. Tong LJ, Balakrishnan G, Kochan JP et al. (1997) Assessment of autoimmunity in patients with chronic urticaria. 99:461–465

  29. Wedi B, Novacovic V, Koerner M, Kapp A (2000) Chronic urticaria serum induces histamine release, leukotriene production, and basophil CD63 surface expression—inhibitory effects of anti-inflammatory drugs. J Allergy Clin Immunol 105:552–560

    Article  PubMed  Google Scholar 

  30. Zuberbier T, Henz BM, Fiebiger E et al. (2000) Anti-FcεRIalpha serum autoantibodies in different subtypes of urticaria. Allergy 55:951–954

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Urtikaria-Sprechstunde des Zentrums für Immundermatologie, Universitäts-Hautklinik Mainz, Mainz

    M. Metz, M. Magerl, F. Siebenhaar & P. Staubach

  2. Zentrum für Immundermatologie, Universitäts-Hautklink Mainz, Langenbeckstraße 1, 55131 , Mainz

    M. Maurer

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  1. M. Maurer
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  2. M. Metz
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  3. M. Magerl
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  4. F. Siebenhaar
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  5. P. Staubach
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Correspondence to M. Maurer.

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Maurer, M., Metz, M., Magerl, M. et al. Autoreaktive Urtikaria und Autoimmunurtikaria. Hautarzt 55, 350–356 (2004). https://doi.org/10.1007/s00105-004-0692-9

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  • DOI: https://doi.org/10.1007/s00105-004-0692-9

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