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Die Variante der Creutzfeldt-Jakob-Krankheit (vCJK)

Epidemiologie, Erkennung, Diagnostik und Prävention unter besonderer Berücksichtigung der Risikominimierung einer iatrogenen Übertragung durch Medizinprodukte, insbesondere chirurgische Instrumente — Abschlussbericht der Task Force vCJK zu diesem Thema

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Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Aims and scope

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Literatur

  1. Hörnlimann B, Riesner D, Kretzschmar H (2001) Prionen und Prionkrankheiten. Walter de Gruyter, Berlin New York

    Google Scholar 

  2. Prusiner SB (2001) Shattuck lecture — neurodegenerative diseases and prions. N Engl J Med 344:1516–1526

    Article  PubMed  CAS  Google Scholar 

  3. Brown P, Preece JP, Brandel T et al. (2000) Iatrogenic Creutzfeldt-Jakob disease at the millenium. Neurology 55:1075–1081

    Google Scholar 

  4. Hill AF, Desbruslais M, Joiner S et al. (1997) The same prion strain causes vCJD and BSE. Nature 389:448–449

    Google Scholar 

  5. Bruce ME, Will RG, Ironside JW, McConnell I, Drummond D, Suttie A, McCardle L, Chree A, Hope J, Birkett C, Cousens S, Fraser H, Bostock CJ (1997) Transmission to mice indicate that new variant CJD is caused by the BSE agent. Nature 389:498–501

    Article  PubMed  CAS  Google Scholar 

  6. Duffy P, Wolf J, Collins G, DeVoe AG, Streeten B, Cowen D (1974) Possible person to person transmission of Creutzfeldt-Jakob disease. N Engl J Med 290:693–693

    Google Scholar 

  7. Adams DH, Edgar WM (1978) Transmission of agent of Creutzfeldt-Jakob disease. Br Med J 1:987

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  8. Gibbs CJ Jr., Asher DM, Kobrine A, Amyx HL, Sulima MP, Gajdusek DC (1994) Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes contaminated during neurosurgery. J Neurol Neurosurg Psychiatry 57:757–758

    Article  PubMed Central  PubMed  Google Scholar 

  9. Heckmann JG, Lang CJ, Petruch F, Druchky A, Erb C, Brown P, Neudorfer B (1997) Transmission of CJD via corneal transplant. J Neurol Neurosurg Psychiatry 63:388–390

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  10. Will RG, Ironside JW, Zeidler M (1996) A new variant of Creutzfeldt-Jacob disease in the UK. Lancet 347:921–925

    Article  PubMed  CAS  Google Scholar 

  11. Brown P, Will RG, Bradley R, Asher DM, Detwiler L (2001) Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: background, evolution and current concerns. Emerg Infect Dis 7:6–16

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  12. Lasmézas CI, Fournier JG, Nouvel V, Boe H, Marce D, Lamoury F, Kopp N, Hauw JJ, Ironside J, Bruce M, Dormont D, Deslys JP (2001) Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-Jakob disease: implications for human health. Proc Natl Acad Sci USA 98:4142–4147

    Article  PubMed Central  PubMed  Google Scholar 

  13. Hilton DA, Fathers E, Edwards P, Ironside JW, Zajucek J (1998) Prion immunoreactivity in appendix before clinical onset of variant CJD. Lancet 352:703–704

    Google Scholar 

  14. Hill AF, Butterworth RJ, Joiner S, Jackson G, Rossor MN, Thomas DJ, Frosh A, Tollev N, Bell JE, Spencer M, King A, Al-Saarj S, Ironside JW, Lantos PL, Collinge J (1999) Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet 353:183–189

    Article  PubMed  CAS  Google Scholar 

  15. Bruce ME, McConnell I, Will RG, Ironside JW (2001) Detection of variant CJD infectivity in extraneural tissues. Lancet 358:208–209

    Article  PubMed  CAS  Google Scholar 

  16. Ironside JW, Hilton DA, Ghani A, Johnston NJ, Conyers L, McCardle LM, Best D (2000) Retrospective study on prion-protein accumulation in tonsil and appendix tissues. Lancet 355:1693–1694

    Article  PubMed  CAS  Google Scholar 

  17. Wadsworth JDF, Joiner S, Hill AF, Campbell TA, Desbruslais M, Luthert PJ, Collinge J (2001) Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jacob disease using a highly sensitive immunoblotting assay. Lancet 358:171–180

    Article  PubMed  CAS  Google Scholar 

  18. Schreuder BEC, Geertsma RE, van Keulen LJ, van Asten JA, Enthoven P, Oberthur RC, de Koeijer AA, Osterhaus AD (1998) Studies on the efficacy of hyperbaric rendering procedures in inactivating bovine spongiform encephalopathy (BSE) and scrapie agents. Vet Rec 142:474–480

    Article  PubMed  CAS  Google Scholar 

  19. Rutala WA, Weber DJ (2001) Creutzfeldt-Jakob disease. Recommendations for disinfection and sterilization. Clin Infect Dis 32:1348–1356

    Article  PubMed  CAS  Google Scholar 

  20. Taylor DM (1999) Inactivation of prions by physical and chemical means. J Hospital Infect 43 [Suppl]:69–76

    Article  Google Scholar 

  21. Taylor DM (2000) Inactivation of transmissible degenerative encephalopathy agents: a review. Vet J 159:10–17

    Article  PubMed  CAS  Google Scholar 

  22. Block S 2001 Disinfection, sterilization,and preservation, 5th edn. Verlag Lippincolt Williams u.Wilkins

  23. Risk assessment for transmission of variant CJD via surgical instruments: a modelling approach and numerical scenarios. Economics and Operational Research Division Department of Health, December 2000, London, http://www.doh.gov.uk/cjd/riskassessmentsi.htm

  24. Laurenson IF, Whyte AS, Fox C, Babb JR (1999) Contaminated surgical instruments and variant Creutzfeldt-Jakob disease. Lancet 354:1823

    Article  PubMed  CAS  Google Scholar 

  25. Taylor DM, Fraser JR (2000) Letters to the editor/The potential risk of transmitting vCJD through surgery. J Hosp Inf 44:318–319

    Article  CAS  Google Scholar 

  26. Axon A, Beilenhoff U, Bramble MG et al. (2001) Variant Creutzfeldt-Jakob disease (vCJD) and gastrointestinal endoscopy. Endoscopy 33:1070–1080

    Google Scholar 

  27. Shmakow AN, Gosh S (2001) Prion proteins and the gut: une liaison dangereuse? Gut 48:443–447

    Google Scholar 

  28. Kretzschmar HA (2001) BSE und die neue Variante der Creutzfeldt-Jakob-Krankheit. Dtsch Ärztebl 98:A; 40:2576–2583

    Google Scholar 

  29. Manuelidis EE, Angelo JN, Gorgacz EJ, Kim JH, Manuelidis L (1977) Experimental CJD transmitted via the eye with infected cornea. N Engl J Med:1334–1337

    Google Scholar 

  30. Carp RI (1982) Transmission of scrapie by the oral route: effect of gingival scarification. Lancet:170–171

    Google Scholar 

  31. Brown P, Gibbs CJ Jr, Rodger-Johnson P et al. (1994) Human spongiform encephalopathy: The National Institutes of Health Series of 300 cases of experimentally transmitted disease. Ann Neurol 35:513–529

    Google Scholar 

  32. Fraser JR (1996) Infectivity in extraneural tissues following intraocular scrapie infection. J Gen Virol 77:2663–2668

    Article  PubMed  CAS  Google Scholar 

  33. Ingrosso L, Pisani F, Pocchiari M (1999) Transmission of the 263 K scrapie agent by the dental route. J Gen Virol 80:3043–3047

    PubMed  CAS  Google Scholar 

  34. Antloga K, Meszaros J, Malchesky PS, McDonnel GE (2000) Prion disease and medical devices. ASAIO J 46:69–72

    Article  Google Scholar 

  35. Schulz-Schaeffer WJ, Beekes W, Kretzschmar H (2001) Die Pathophysiologie von Prionkrankheiten nach peripherer Übertragung. In: Hörnlimann B, Riesner D, Kretzschmar H (Hrsg) Prionen und Prionkrankheiten. De Gruyter, Berlin, S231–235

    Google Scholar 

  36. Sautereau D, Palazzo L (2001) Pinces à biopsie à usage unique en endoscopie digestive: sage décision ou caricature du principe de précautation? Gastroenterol Clin Biol 25:653–655

    PubMed  CAS  Google Scholar 

  37. Verjat D, Prognon P, Darbold JC (1999) Fluorescence-assay on traces of protein on re-usable medical devices: cleaning efficiency. Int J Pharm 179:267–271

    Article  PubMed  CAS  Google Scholar 

  38. Brown P, Rohwer RG, Green EM, Gajdusek DC (1982) Effect of chemicals, heat, and histopathologic processing on high-infectivity hamster-adapted scrapie virus. J Infect Dis 145:683–687

    Article  PubMed  CAS  Google Scholar 

  39. Brown P, Rohwer RG, Gajdusek DC (1986) Newer data on the inactivation of scrapie virus or Creutzfeldt-Jakob disease virus in brain tissue. J Infect Dis 153:1145–1148

    Article  PubMed  CAS  Google Scholar 

  40. Rohwer RG (1984) Virus-like sensitivity of scrapie agent to heat inactivation. Science 223:600–602

    Article  PubMed  CAS  Google Scholar 

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Die Variante der Creutzfeldt-Jakob-Krankheit (vCJK). Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz 45, 376–394 (2002). https://doi.org/10.1007/s00103-002-0393-4

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