Zusammenfassung
Die periphere Regionalanästhesie ist ein sicheres Anästhesieverfahren. Allgemeine Komplikationen sind selten. Schwere Nervenschäden treten je nach Definition mit einer Inzidenz <0,1% auf und haben oft eine gute Prognose. Zur Vermeidung von Blutungskomplikationen gibt es nationale Richtlinien zur Durchführung unter laufender Antikoagulation, die beachtet werden müssen. Intoxikationen treten v. a. bei versehentlicher intravasaler Gabe auf und sind teilweise schwer therapierbar; die Gabe von Fettlösung kann die Reanimierbarkeit der Patienten verbessern. Infektionen können v. a. bei Katheterverfahren auftreten und bedingen ein streng aseptisches Vorgehen bei der Anlage. Seltene Komplikationen sind Allergien, Dislokationen sowie Katheterabrisse oder Schlingenbildungen. Neben den allgemeinen Komplikationen gibt es verfahrenstypische Komplikationen wie z. B. einen Pneumothorax oder Nierenpunktionen, die einer besonderer Beachtung bedürfen.
Abstract
Peripheral regional anesthesia is a commonly used and safe procedure and eneral complications or side effects are generally rare. Nerve damage has an incidence <0.1% depending on the definition and the prognosis is good. To avoid bleeding complications the national standards of block performance under antithrombotic therapy should be respected. Intoxication is mainly the result of accidental intravenous administration and is difficult to treat but higher doses of intravenous lipid emulsions can improve the outcome. Potential infectious complications can occur mainly as a result of catheter techniques and require a strict aseptic approach. Further rare complications are allergies, dislocation of catheters and knotting or loops in catheters. Besides the general complications, there are some specific complications depending on the puncture site, such as pneumothorax or renal puncture.
Literatur
Abrahams MS, Aziz MF, Fu RF et al (2009) Ultrasound guidance compared with electrical neurostimulation for peripheral nerve block: a systematic review and meta-analysis of randomized controlled trials. Br J Anaesth 102:408–417
Aida S, Takahashi H, Shimoji K (1996) Renal subcapsular hematoma after lumbar plexus block. Anesthesiology 84:452–455
Aly H, Herson V, Duncan A et al (2005) Is bloodstream infection preventable among premature infants? A tale of two cities. Pediatrics 115:1513–1518
Auroy Y, Benhamou D, Bargues L et al (2002) Major complications of regional anesthesia in France: the SOS Regional Anesthesia Hotline Service. Anesthesiology 97:1274–1280
Barrington MJ, Watts SA, Gledhill SR et al (2009) Preliminary results of the Australasian Regional Anaesthesia Collaboration: a prospective audit of more than 7000 peripheral nerve and plexus blocks for neurologic and other complications. Reg Anesth Pain Med 34:534–541
Benumof JL (2000) Permanent loss of cervical spinal cord function associated with interscalene block performed under general anesthesia. Anesthesiology 93:1541–1544
Bernards CM, Hadzic A, Suresh S et al (2008) Regional anesthesia in anesthetized or heavily sedated patients. Reg Anesth Pain Med 33:449–460
Bhatia A, Lai J, Chan VW et al (2010) Pneumothorax as a complication of the ultrasound-guided supraclavicular approach for brachial plexus block. Anesth Analg 111:817–819
Bickler P, Brandes J, Lee M et al (2006) Bleeding complications from femoral and sciatic nerve catheters in patients receiving low molecular weight heparin. Anesth Analg 103:1036–1037
Bigeleisen PE (2006) Nerve puncture and apparent intraneural injection during ultrasound-guided axillary block does not invariably result in neurologic injury. Anesthesiology 105: 779–783
Bigeleisen PE, Moayeri N, Groen GJ (2009) Extraneural versus intraneural stimulation thresholds during ultrasound-guided supraclavicular block. Anesthesiology 110:1235–1243
Bigeleisen PE, Groen GJ, Moayeri N (2010) Ultrasound-guided supraclavicular block: what is intraneural? Anesthesiology 112:250–252
Bonnet F, Marret E (2005) Influence of anaesthetic and analgesic techniques on outcome after surgery. Br J Anaesth 95:52–58
Borgeat A, Dullenkopf A, Ekatodramis G et al (2003) Evaluation of the lateral modified approach for continuous interscalene block after shoulder surgery. Anesthesiology 99:436–442
Borgeat A, Ekatodramis G (2002) Brachial plexus block. Curr Opin Anaesthesiol 15:537–542
Braid DP, Scott DB (1965) The systemic absorption of local analgesic drugs. Br J Anaesth 37:394–404
Brull R, McCartney CJ, Chan VW et al (2007) Neurological complications after regional anesthesia: contemporary estimates of risk. Anesth Analg 104:965–974
Büttner J, Meier G (1999) Kontinuierliche periphere Techniken zur Regionalanästhesie und Schmerztherapie. UniMed, Bremen, S 56
Büttner J (2003) Nervenblockaden an der oberen Extremität. In: Van Aken H (Hrsg) Lokalanästhesie, Regionalanästhesie, Regionale Schmerztherapie. 2. Aufl. Kapitel 8. Thieme, Stuttgart, S 268
Büttner J, Bürkle H, Gogarten W et al (2005) Thromboembolieprophylaxe bei peripheren Blockadetechniken zur Regionalanästhesie. Leitlinie der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin. Anasthesiol Intensivmed Notfallmed Schmerzther 46:319–322
Burgher AH, Hebl JR (2007) Minimally invasive retrieval of knotted nonstimulating peripheral nerve catheters. Reg Anesth Pain Med 32:162–166
Capdevila X, Pirat P, Bringuier S et al (2005) Continuous peripheral nerve blocks in hospital wards after orthopedic surgery: a multicenter prospective analysis of the quality of postoperative analgesia and complications in 1,416 patients. Anesthesiology 103:1035–1045
Capdevila X, Bringuier S, Borgeat A (2009) Infectious risk of continuous peripheral nerve blocks. Anesthesiology 110:182–188
Clendenen SR, Robards CB, Wang D et al (2010) Continuous interscalene block associated with neck hematoma and postoperative sepsis. Anesth Analg 110:1236–1238
Collet JP, Montalescot G, Blanchet B et al (2004) Impact of prior use or recent withdrawal of oral antiplatelet agents on acute coronary syndromes. Circulation 110:2361–2367
Cometa MA, Esch AT, Boezaart AP (2011) Did continuous femoral and sciatic nerve block obscure the diagnosis or delay the treatment of acute lower leg compartment syndrome? Pain Med 12:823–828
Compère V, Legrand JF, Guitard PG et al (2009) Bacterial colonization after tunneling in 402 perineural catheters: a prospective study. Anesth Analg 108:1326–1330
Corman SL, Skledar SJ (2007) Use of lipid emulsion to reverse local anesthetic-induced toxicity. Ann Pharmacother 41:1873–1877
Cuvillon P, Ripart J, Lalourcey L et al (2001) The continuous femoral nerve block catheter for postoperative analgesia: bacterial colonization, infectious rate and adverse effects. Anesth Analg 93:1045–1049
Englesson S (1974) The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents I. Acta Anaesthesiol Scand 18:79–87
Englesson S, Grevsten S (1974) The influence of acid-base changes on central nervous system toxicity of local anaesthetic agents II. Acta Anaesthesiol Scand 18:88–103
Felice K, Schumann H (2008) Intravenous lipid emulsion for local anesthetic toxicity: a review of the literature. J Med Toxicol 4:184–191
Ferrari E, Benhamou M, Cerboni P et al (2005) Coronary syndromes following aspirin withdrawal: a special risk for late stent thrombosis. J Am Coll Cardiol 45:456–459
Förster JG, Rosenberg PH (2003) Clinically useful adjuvants in regional anesthesia. Curr Opin Anaesthesiol 16:477–486
Fredrickson MJ, Kilfoyle DH (2009) Neurological complication analysis of 1000 ultrasound guided peripheral nerve blocks for elective orthopaedic surgery: a prospective study. Anaesthesia 64:836–844
Fulkerson E, Razi A, Tejwani N (2003) Review: acute compartment syndrome of the foot. Foot Ankle Int 24:180–187
Gogarten W, Vandermeulen E, Van Aken H, European Society of Anaesthesiology (2010) Regional anaesthesia and antithrombotic agents: recommendations of the European Society of Anaesthesiology. Eur J Anaesthesiol 27:999–1015
Graf BM, Niesel HC (2003) Pharmakologie der Lokalanästhetika. In: Van Aken H (Hrsg) Lokalanästhesie, Regionalanästhesie, Regionale Schmerztherapie. 2. Aufl. Kapitel 2. Thieme, Stuttgart, S 34–119
Hadzic A, Dilberovic F, Shah S et al (2004) Combination of intraneural injection and high injection pressure leads to fascicular injury and neurologic deficits in dogs. Reg Anesth Pain Med 29:417–423
Haessler S, Connelly NR, Kanter G et al (2010) A surgical site infection cluster: the process and outcome of an investigation – the impact of an alcohol-based surgical antisepsis product and human behavior. Anesth Analg 110:1044–1048
Hanna MN, Murphy JD, Kumar K et al (2009) Regional techniques and outcome: what is the evidence? Curr Opin Anaesthesiol 22:672–677
Hartrick CT, Dirkes WE, Coyle DE et al (1984) Influence of bupivacaine on mepivacaine protein binding. Clin Pharmacol Ther 36:546–550
Haynes AB, Weiser TG, Berry WR et al (2009) A surgical safety checklist to reduce morbidity and mortality in a global population. N Engl J Med 360:491–499
Hempel V (1999) Anästhesie des Plexus brachialis. Anaesthesist 48:341–355
Hiller DB, Di Gregorio G, Kelly K et al (2010) Safety of high volume lipid emulsion infusion: a first approximation of LD50 in rats. Reg Anesth Pain Med 35:140–144
Horlocker TT, Kufner RP, Bishop AT et al (1999) The risk of persistent paresthesia is not increased with repeated axillary block. Anesth Analg 88:382–387
Horlocker TT, Birnbach DJ, Connis RT et al (2010) Practice advisory for the prevention, diagnosis, and management of infectious complications associated with neuraxial techniques: a report by the American Society of Anesthesiologists Task Force on infectious complications associated with neuraxial techniques. Anesthesiology 112:530–545
Horlocker TT, Wedel DJ, Rowlingson JC et al (2010) Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (third edition). Reg Anesth Pain Med 35:64–101
Jenkins CR, Karmakar MK (2005) An unusual complication of interscalene brachial plexus catheterization: delayed catheter migration. Br J Anaesth 95:535–537
Jeske C, Raedler C, Goedecke A von et al (2003) Early identification of bacteria leading to central venous catheter contamination. Anesth Analg 97:940–943
Kaiser H, Niesel HC, Hans V (1990) Grundlagen und Anforderungen der peripheren elektrischen Nervenstimulation. Ein Beitrag zur Erhöhung des Sicherheitsstandards in der Regionalanästhesie. Reg Anesth Pain Med 13:143–147
Kampf G, Pitten FA, Heeg P et al (2007) Efficacy of two ethanol-based skin antiseptics on the forehead at shorter application times. BMC Microbiol 7:85 (http://www.biomedcentral.com/1471-2180/7/85)
Kempen PM, O’Donnell J, Lawler R et al (2000) Acute respiratory insufficiency during interscalene plexus block. Anesth Analg 90:1415–1416
Klein SM, D’Ercole F, Greengrass RA et al (1997) Enoxaparin associated with psoas hematoma and lumbar plexopathy after lumbar plexus block. Anesthesiology 87:1576–1579
Kozek-Langenecker SA, Fries D, Gutl M et al (2005) Lokoregionalanästhesien unter gerinnungshemmender Medikation – Empfehlungen der Arbeitsgruppe Perioperative Gerinnung (AGPG) der Österreichischen Gesellschaft für Anästhesiologie Reanimation und Intensivmedizin (ÖGARI). Anaesthesist 54:476–484
Lee LA, Posner KL, Domino KB et al (2004) Injuries associated with regional anesthesia in the 1980s and 1990s: a closed claims analysis. Anesthesiology 101:143–152
Lee LA, Posner KL, Cheney FW et al (2008) Complications associated with eye blocks and peripheral nerve blocks: an American Society of Anesthesiologists closed claims analysis. Reg Anesth Pain Med 33:416–422
Leskiw U, Weinberg GL (2009) Lipid resuscitation for local anesthetic toxicity: is it really lifesaving? Curr Opin Anaesthesiol 22:667–671
Litz RJ, Vicent O, Wiessner D et al (2004) Misplacement of a psoas compartment catheter in the subarachnoid space. Reg Anesth Pain Med 29:60–64
Lupu CM, Kiehl TR, Chan VWS et al (2010) Nerve expansion seen on ultrasound predicts histologic but not functional nerve injury after intraneural injection in pigs. Reg Anesth Pain Med 35:132–139
MacDonald KS, Sites BD (2010) Electron microscopy evaluation of block needle-related trauma to the tibial nerve. Acta Anaesthesiol Scand 54:426–429
Marhofer P, Harrop-Griffiths W, Kettner SC et al (2010) Fifteen years of ultrasound guidance in regional anaesthesia: Part 1. Br J Anaesth 104:538–546
McNamara PJ, Slaughter RL, Pieper JA et al (1981) Factors influencing serum protein binding of lidocaine in humans. Anesth Analg 60:395–400
Meier G, Bauereis C, Heinrich C (1997) Interscalene brachial plexus catheter for anesthesia and postoperative pain therapy. Experience with a modified technique. Anaesthesist 46:715–719
Meier G (2003) Nervenblockaden an der unteren Extremität. In: Van Aken H (Hrsg) Lokalanästhesie, Regionalanästhesie, Regionale Schmerztherapie. 2. Aufl. Kapitel 9. Thieme, Stuttgart, S 306
Meier G, Büttner J (2003) Allgemeine Aspekte peripherer Nervenblockaden der Extremitäten. In: Van Aken H (Hrsg) Lokalanästhesie, Regionalanästhesie, Regionale Schmerztherapie. 2. Aufl. Kapitel 7. Thieme, Stuttgart, S 237–266
Meier G, Büttner J (2006) Atlas der peripheren Regionalanästhesie. 2. Aufl. Kapitel 2. Thieme, Stuttgart, S 26
Moore DC (1997) No paresthesias – no anesthesia, the nerve stimulator or neither? Reg Anesth Pain Med 22:388–390
Morfey D, Brull R (2010) Ultrasound-guided supraclavicular block: what is intraneural? Anesthesiology 112:250–252
Morin AM, Kerwat KM, Büttner J et al (2006) Hygiene recommendations for the initiation and continued care of regional anaesthetic procedures – The 15 „musts“ of the Scientific Working Group Regional Anaesthesia. Anasthesiol Intensivmed Notfallmed Schmerzther 47:372–379
Morishima H, Pedersen H, Finster M et al (1985) Bupivacaine toxicity in pregnant and nonpregnant ewes. Anesthesiology 63:134–139
Neal JM, Bernards CM, Hadzic A et al (2008) ASRA practice advisory on neurologic complications in regional anesthesia and pain medicine. Reg Anesth Pain Med 33:404–415
Neal JM, Bernards CM, Butterworth JF 4th et al (2010) ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med 35:152–161
Neuburger M, Kaiser H, Rembold-Schuster I et al (1998) Vertical infraclavicular brachial-plexus blockade. A clinical study of reliability of a new method for plexus anesthesia of the upper extremity. Anaesthesist 47:595–599
Neuburger M, Büttner J (2005) Der abgescherte Schmerzkatheter. Regional Express 1:8 (http://www.internetregionalexpress.de/journal/pdf/Reg_Exp_1_2005.pdf)
Neuburger M, Breitbarth J, Reisig F et al (2006) Complications and adverse events in continuous peripheral regional anesthesia. Results of investigations on 3,491 catheters. Anaesthesist 55:33–40
Neuburger M, Büttner J, Blumenthal S et al (2007) Inflammation and infection complications of 2285 perineural catheters: a prospective study. Acta Anaesthesiol Scand 51:108–114
Neuburger M, Büttner J (2009) Allgemeine oder Regionale Anästhesie in der Extremitätenchirurgie. In: Eckart J, Jaeger K, Möllhoff T (Hrsg) Anästhesiologie. Kapitel 6.2.2. EcoMed, Landsberg
Neuburger M, Reisig F, Zimmermann L (2009) Infection control in continuous peripheral regional anesthesia. Clinical study on disinfection time and subcutaneous tunneling in interscalene plexus anesthesia. Anaesthesist 58:795–799
Neuburger M, Kaiser H (2010) Nicht ohne meinen Nervenstimulator – die periphere elektrische Nervenstimulation in der Regionalanästhesie. In Eckart J, Jaeger K, Möllhoff T (Hrsg) Anästhesiologie. Kapitel 6.2.9. EcoMed, Landsberg
Neugebauer E, Laubenthal H, Becker M (2009) S3-Leitlinie. Behandlung akuter perioperativer und posttraumatischer Schmerzen. (AWMF-Register Nr. 041/001)
O’Grady NP, Alexander M, Dellinger EP et al (2002) Guidelines for the prevention of intravascular catheter-related infections. The Hospital Infection Control Practices Advisory Committee (HICPAC), Center for Disease Control and Prevention (CDC). MMWR Recomm Rep 51:1–29
Perlas A, Niazi A, McCartney C et al (2006) The sensitivity of motor response to nerve stimulation and paresthesia for nerve localization as evaluated by ultrasound. Reg Anesth Pain Med 31:445–450
Perthes G (1912) Über Leitungsanästhesie unter Zuhilfenahme elektrischer Reizung. Munch Med Wochenschr 47:2545–2551
Pronovost P, Needham D, Berenholtz S et al (2006) An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 355:2725–2732. (Erratum in: N Engl J Med. 2007 Jun 21;356:2660)
Rettig HC, Gielen MJ, Jack NT et al (2006) A comparison of the lateral and posterior approach for brachial plexus block. Reg Anesth Pain Med 31:119–126
Rotzinger M, Neuburger M, Kaiser H (2004) Inadvertant epidural placement of a psoas compartment catheter. Case report of a rare complication. Anaesthesist 53:1069–1072
Rupp SM (2008) Unintentional wrong-sided peripheral nerve block. Reg Anesth Pain Med 33:95–97
Selander D, Dhunér KG, Lundborg G (1977) Peripheral nerve injury due to injection needles used for regional anesthesia. An experimental study of the acute effects of needle point trauma. Acta Anaesthesiol Scand 21:182–188
Sorrentino F, Eggli S, Stricker U et al (1998) Missed compartment syndrome after anterior cruciate ligament-plasty following continuous peridural anesthesia. Unfallchirurg 101:491–494
Stadlmeyer W, Neubauer J, Finkl RO et al (2000) Unilateral phrenic nerve paralysis after vertical infraclavicular plexus block. Anaesthesist 49:1030–1033
Steffen P, Seeling W, Essig A (2004) Bacterial contamination of epidural catheters: microbiological examination of 502 epidural catheters used for postoperative analgesia. J Clin Anesth 16:92–97
Steinfeldt T, Nimphius W, Werner T (2010) Nerve injury by needle nerve perforation in regional anaesthesia: does size matter? Br J Anaesth 104:245–253
Steinfeldt T, Werner T, Nimphius W (2011) Histological analysis after peripheral nerve puncture with pencil-point or Tuohy needletip. Anesth Analg 112:465–470
Sztark F, Malgat M, Dabadie P et al (1998) Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics. Anesthesiology 88:1340–1349
Thomas PW, Sanders DJ, Berrisford RG (1999) Pulmonary haemorrhage after percutaneous paravertebral block. Br J Anaesth 83:668–669
Tsui BC, Pillay JJ, Chu KT et al (2008) Electrical impedance to distinguish intraneural from extraneural needle placement. Anesthesiology 109:479–483
Urmey WF (2000) Interscalene block: the truth about twitches. Reg Anesth Pain Med 25:340–342
Urmey WF, Stanton J (2002) Inability to consistently elicit a motor response following sensory paresthesia during interscalene block administration. Anesthesiology 96:552–554
Vandermeulen E (2003) Guidelines on anticoagulants and the use of locoregional anesthesia. Minerva Anestesiol 69:407–411
Volk T, Engelhardt L, Spies C (2009) Incidence of infection from catheter procedures for regional anesthesia: first results from the network of DGAI and BDA. Anaesthesist 58:1107–1112
Volk T, Engelhardt L, Spies C (2009) A German network for regional anaesthesia of the scientific working group regional anaesthesia within DGAI and BDA. Anasthesiol Intensivmed Notfallmed Schmerzther 44:778–780
Volk T, Engelhardt L, Spies C et al (2009) Incidence of infection from catheter procedures for regional anesthesia: first results from the network of DGAI and BDA. Anaesthesist 58:1107–1112
Volk T, Graf BM, Gogarten W et al (2009) Empfehlungen zur Lipidbehandlung bei der Intoxikation mit Lokalanästhetika. Anasthesiol Intensivmed Notfallmed Schmerzther 50:698–702
Weller RS, Gerancher JC, Crews JC et al (2003) Extensive retroperitoneal hematoma without neurologic deficit in two patients who underwent lumbar plexus block and were later anticoagulated. Anesthesiology 98:581–585
Zausig YA, Zink W, Keil M et al (2009) Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest. Anesth Analg 109:1323–1326
Zink W, Graf BM (2003) Toxicology of local anesthetics. Clinical, therapeutic and pathological mechanisms. Anaesthesist 52:1102–1123
Interessenkonflikt
Der korrespondierende Autor weist auf folgende Beziehungen hin: Beide Autoren: gelegentlich Vortragstätigkeiten für die Fa. AstraZeneca.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Neuburger, M., Büttner, J. Komplikationen bei peripherer Regionalanästhesie. Anaesthesist 60, 1014–1026 (2011). https://doi.org/10.1007/s00101-011-1955-3
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00101-011-1955-3