Zusammenfassung
„Target-controlled infusion“ (TCI) ist seit der kommerziellen Einführung im Jahr 1996 zu einer etablierten Applikationsform intravenöser Anästhetika geworden. Zusätzliche Optionen der modernen TCI-Systeme wie die Wahl zwischen unterschiedlichen Modellen und Applikationsmodi verkomplizieren allerdings den Gebrauch für den wenig erfahrenen Benutzer. Die vorliegende Übersicht beschreibt die Unterschiede der pharmakokinetischen Modelle, der Applikationsmodi und den Einfluss von Kovariaten sowie die Konsequenzen für die Dosierung mit dem Ziel, dem Benutzer von modernen TCI-Systemen die zugrunde liegenden wissenschaftlichen Konzepte und deren Bedeutung für die klinische Praxis zu vermitteln.
Abstract
Since its commercial introduction in 1996, target-controlled infusion (TCI) has become an established technique for administration of intravenous anaesthetics. Modern TCI systems, however, are characterized by an increasing number of additional options and features, such as the choice between different pharmacokinetic models and modes of application, which may confuse the less experienced user. This review describes the differences between pharmacokinetic models, modes of application and the effect of covariates as well as the consequences for dosing. The aim is to explicate for the user of modern TCI systems the underlying scientific concepts and the relevance for clinical practice.
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Interessenkonflikt
Alle Autoren sind Mitglied eines von Fresenius-Kabi Deutschland GmbH unterstützten „Target-Controlled Infusion Expert Board“. Dieses Projekt wurde durch ein Grant der Fresenius-Kabi unterstützt.
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Ihmsen, H., Schraag, S., Kreuer, S. et al. „Target-controlled infusion“. Anaesthesist 58, 708–715 (2009). https://doi.org/10.1007/s00101-009-1575-3
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DOI: https://doi.org/10.1007/s00101-009-1575-3