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Determination of the connectivity of newborn neurons in mammalian olfactory circuits

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Abstract

The mammalian olfactory bulb is a forebrain structure just one synapse downstream from the olfactory sensory neurons and performs the complex computations of sensory inputs. The formation of this sensory circuit is shaped through activity-dependent and cell-intrinsic mechanisms. Recent studies have revealed that cell-type specific connectivity and the organization of synapses in dendritic compartments are determined through cell-intrinsic programs already preset in progenitor cells. These progenitor programs give rise to subpopulations within a neuron type that have distinct synaptic organizations. The intrinsically determined formation of distinct synaptic organizations requires factors from contacting cells that match the cell-intrinsic programs. While certain genes control wiring within the newly generated neurons, other regulatory genes provide intercellular signals and are only expressed in neurons that will form contacts with the newly generated cells. Here, the olfactory system has provided a useful model circuit to reveal the factors regulating assembly of the highly structured connectivity in mammals.

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Abbreviations

AON:

Anterior olfactory cortex

EPL:

External plexiform layer

ETC:

External tufted cells

GC:

Granule cell

GCL:

Granule cell layer

MC:

Mitral cell

MCL:

Mitral cell layer

MTC:

Middle tufted cells

OSN:

Olfactory sensory neurons

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The work was funded by DFG KE1661/1-1 to W.K. The authors declare no competing financial interests.

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Ravi, N., Sanchez-Guardado, L., Lois, C. et al. Determination of the connectivity of newborn neurons in mammalian olfactory circuits. Cell. Mol. Life Sci. 74, 849–867 (2017). https://doi.org/10.1007/s00018-016-2367-y

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