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Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm

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Abstract

Allergy and anaphylaxis are inflammatory disorders caused by immune reactions mainly induced by immunoglobulin-E that signal through the high-affinity FcεRI receptor to release the inflammatory mediators from innate immune cells. The FcεRI/mast cell axis is potently involved in triggering various intracellular signaling molecules to induce calcium release from the internal stores, induction of transcription factors such as NF-kB, secretion of various cytokines as well as lipid mediators, and degranulation, resulting in the induction of allergy and anaphylaxis. In this review, we discuss various cellular and molecular mechanisms triggered through FcεRI/mast cell axis in allergy and anaphylaxis with a special emphasis on the functional genomics paradigm.

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Acknowledgments

The authors would like to thank the various research groups around the globe for their exceptional contributions in the basic, translational, and clinical aspects of allergy and anaphylaxis. We really regret the omission of any of these findings or contributions on the FcεRI/Mast cell axis in this review, which is mainly due to space limitations. We extend our immense appreciation to the graphics team of Beacon Biosoft (www.beaconbiosoft.com) for the fantastic figures in our review.

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Authors and Affiliations

  1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore

    Jayapal Manikandan & Manoor Prakash Hande

  2. Center of Excellence in Genomic Medicine Research (CEGMR), King Fahad Medical Research Center, King AbdulAziz University, Jeddah, 21589, Saudi Arabia

    Jayapal Manikandan, Narasimhan Kothandaraman & Peter Natesan Pushparaj

  3. Tembusu College, University Town, 28 College Avenue East, B1-01, Singapore, 138598, Singapore

    Manoor Prakash Hande

  4. Institute of Immunity, Infection and Inflammation, College of Medicine, Veterinary and Life Sciences, 120 Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, G12 8TA, UK

    Peter Natesan Pushparaj

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  1. Jayapal Manikandan
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  2. Narasimhan Kothandaraman
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Correspondence to Manoor Prakash Hande or Peter Natesan Pushparaj.

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Manikandan, J., Kothandaraman, N., Hande, M.P. et al. Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm. Cell. Mol. Life Sci. 69, 1917–1929 (2012). https://doi.org/10.1007/s00018-011-0886-0

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  • DOI: https://doi.org/10.1007/s00018-011-0886-0

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