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Lack of reduction in body fat after treatment with insulin-like growth factor-I in two children with growth hormone gene deletions

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Abstract

Two patients with growth hormone (GH) gene deletions were treated with recombinant insulin-like growth factor-I (IGF-I) (80–240 (μg/kg/ day) and the effects on bone mass and body composition were compared to administration of GH (0.075 U/kg/day) to 8 patients with idiopathic GH deficiency. Bone mass and body composition were measured by dual photon X-ray absorptiometry (DEXA) before and 3 and 6 months after treatment with GH or IGF-I. Similar increases in growth velocities were observed after GH and IGF-I treatment. Treatment with GH resulted in prompt and significant reduction in body fat percentage (basal, 3 and 6 months: 22±10, 17±9, and 16±9%) whereas body fat percentage remained unchanged after IGF-I therapy (basal, 3 and 6 months: 49, 52 and 48% in patient 1 and 45, 42 and 43% in patient 2, respectively). Fat percentage remained elevated after 18 months of IGF-I treatment in patients 1 (51%) and 2 (44%), respectively. Lean mass and bone mineral content increased with GH and IGF-I therapies. We conclude that reduction of body fat measured by DEXA, observed after administration of GH but not after IGF-I treatment in these children with GH deficiency, suggests that the GH effect on body fat mass is not mediated by circulating IGF-I.

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Authors and Affiliations

  1. Unidade de Endocrinologia do Desenvolvimento, Hospital das Clinicas da Faculdade de Medicina da USP, Caixa Postal 3671, CEP 01060-970, São Paulo, Brazil

    I. J. P. Arnhold M.D., S. B. Oliveira, M. G. F. Osorio, W. Nicolau & B. B. Mendonca

  2. Laboratório de Lípides, Divisão de Endocrinologia, Hospital das Clinicas da Faculdade de Medicina da USP, São Paulo, Brazil

    A. J. F. Carrilho

  3. Departmento de Fisiologia e Biofísica, ICB, Universidade de São Paulo, São Paulo, Brazil

    A. C. Bianco

Authors
  1. I. J. P. Arnhold M.D.
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  2. S. B. Oliveira
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  3. M. G. F. Osorio
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  4. A. J. F. Carrilho
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  5. W. Nicolau
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  6. A. C. Bianco
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  7. B. B. Mendonca
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Correspondence to I. J. P. Arnhold M.D..

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Arnhold, I.J.P., Oliveira, S.B., Osorio, M.G.F. et al. Lack of reduction in body fat after treatment with insulin-like growth factor-I in two children with growth hormone gene deletions. J Endocrinol Invest 23, 258–262 (2000). https://doi.org/10.1007/BF03343719

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  • DOI: https://doi.org/10.1007/BF03343719

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