Abstract
Gold nanoparticles are now widely used in different fields of chemistry, physics and biology. For many applications, it became crucial to use the smallest ones and at the same time to be able to detect them at the single particle level with versatile optical methods. Such methods should also allow the study of their intimate optical properties. Here we review the ultra-sensitive optical methods based on the photothermal effect which permit the detection of individual gold nanoparticles down to 1.4 nm through their absorption. The absorption spectroscopy of the Surface Plasmon Resonance of individual gold nanoparticles down to 5nm is further presented and revealed intrinsic size effects in the optical response of the smallest nanoparticles. Different applications to biology are also presented such as for new types of gold nanoparticles based DNA microarrays and for live cell molecular imaging owing to the insensitivity of the photothermal methods to scattering environments.
Article PDF
Similar content being viewed by others
References
U. Kreibig, M. Vollmer,Optical properties of metal clusters; Springer-Verlag: Berlin, 1995
S. Eustis, M.A. El-Sayed,Chemical Society Reviews, 2006,35, 3, 209–217
M.C. Daniel, D. Astruc,Chem. Rev., 2004,104, 1, 293–346
E. Ozbay,Science, 2006,311, 5758, 189–193
N.L. Rosi, C.A. Mirkin,Chem. Rev., 2005,105, 4, 1547–1562
D.A. Schultz,Current Opinion in Biotechnology, 2003,14, 1, 13–22
L. Hirsch, A. Gobin, A. Lowery, F. Tam, R. Drezek, N. Halas, J. West,Annals of Biomedical Engineering, 2006,34, 1, 15
W.E. Moerner, M. Orrit,Science, 1999,283, 5408, 1670–1676
J. Yguerabide, E.E. Yguerabide,J Cell Biochem Suppl, 2001,Suppl 37, 71–81
M. Debrabander, R. Nuydens, G. Geuens, M. Moeremans, J. Demey,Cell Motility And The Cytoskeleton, 1986,6, 2, 105–113
C. Sönnichsen, S. Geier, N.E. Hecker, G. Von Plessen, J. Feldmann, H. Ditlbacher, B. Lamprecht, J.R. Krenn, F.R. Aussenegg, V.Z.H. Chan, J.P. Spatz, M. MoLler,Applied Physics Letters, 2000,77, 19, 2949
J. Yguerabide, E.E. Yguerabide,Anal Biochem, 1998,262, 2, 137–156
S. Schultz, D.R. Smith, J. J. Mock, D.A. Schultz,Proc Natl Acad Sci USA, 2000,97, 3, 996–1001
M.A. Van Dijk, A.L. Tchebotareva, M. Orrit, M. Lippitz, S. Berciaud, D. Lasne, L. Cognet, B. Lounis,Physical Chemistry Chemical Physics, 2006,8, 30, 3486
A. Arbouet, D. Christofilos, N. Del Fatti, F. Vallee, J.R. Huntzinger, L. Arnaud, P. Billaud, M. Broyer,Phys Rev Lett, 2004,93, 12, 127401
K. Lindfors, T. Kalkbrenner, P. Stoller, V. Sandoghdar,Phys Rev Lett, 2004,93, 3, 037401
F.V. Ignatovich, L. Novotny,Physical Review Letters, 2006,96, 1
S. Link, M.A. El-Sayed,Annu Rev Phys Chem, 2003,54, 331–366
J.P. Wilcoxon, J.E. Martin, F. Parsapour, B. Wiedenman, D.F. Kelley,J Chem. Phys., 1998,108, 21, 9137–9143
M. Tokeshi, M. Uchida, A. Hibara, T. Sawada, T. Kitamori,Analytical Chemistry, 2001,73, 9, 2112
D. Boyer, P. Tamarat, A. Maali, B. Lounis, M. Orrit,Science, 2002,297, 5584, 1160–1163
S. Berciaud, L. Cognet, G.A. Blab, B. Lounis,Phys. Rev. Lett., 2004,93, 25, 257402
S. Berciaud, D. Lasne, G.A. Blab, L. Cognet, B. Lounis,Phys. Rev. B, 2006,73, 045424
G.A. Blab, L. Cognet, S. Berciaud, I. Alexandre, D. Husar, J. Remacle, B. Lounis,Biophysical Journal, 2006,90, 1
D. Lasne, G.A. Blab, S. Berciaud, M. Heine, L. Groc, D. Choquet, L. Cognet, B. Lounis,Biophysical Journal, 2006,91, 12, 4598
G. Mie,Ann. Phys., 1908,330, 377–445
C.F. Bohren, D.R. Huffman, J. Wiley (New York), 1983
S. Link, M.A. El Sayed,Int. Reviews in Physical Chemistry, 2000,3, 19, 409–453
J.J. Mock, M. Barbic, D.R. Smith, D.A. Schultz, S. Schultz,J. Chem. Phys., 2002,116, 6755.
C. Sonnichsen, T. Franzl, T. Wilk, G. Von Plessen, J. Feldmann, O. Wilson, P. Mulvaney,Phys Rev Lett, 2002,88, 7, 077402
S. Berciaud, L. Cognet, P. Tamarat, B. Lounis,Nano Lett, 2005,5, 3, 515–518
P.B. Johnson, R.W. Christy,Phys. Rev. B, 1972,6, 12, 4370
J. Bosbach, C. Hendrich, F. Stietz, T. Vartanyan, F. Trager,Phys Rev Lett, 2002,89, 25, 257404
T. Klar, M. Perner, S. Grosse, G. Von Plessen, W. Spirkl, J. Feldmann,Phys Rev Lett, 1998,80, 4249–4252
E. Prodan, C. Radloff, N.J. Halas, P. Nordlander,Science, 2003,302, 5644, 419–422
L.A. Peyser, A.E. Vinson, A.P. Bartko, R.M. Dickson,Science, 2001,291, 5501, 103–106
J. Zheng, R.M. Dickson,J Am Chem Soc, 2002,124, 47, 13982–13983
W.P. Wuelfing, S.M. Gross, D.T. Miles, R.W. Murray,J Am Chem Soc, 1998,120, 48, 12696–12697
G.A. Blab, L. Cognet, S. Berciaud, I. Alexandre, D. Husar, J. Remacle, B. Lounis,Biophys J, 2006,90, 1, L13–15
T.A. Taton, C.A. Mirkin, R.L. Letsinger,Science, 2000,289, 5485, 1757–1760
I. Alexandre, S. Hamels, S. Dufour, J. Collet, N. Zammatteo, F. De Longueville, J.L. Gala, J. Remacle,Anal Biochem, 2001,295, 1, 1–8
W. Fritzsche, T.A. Taton,Nanotechnology, 2003,14, 12, R63-R73
S.J. Park, T.A. Taton, C.A. Mirkin,Science, 2002,295, 5559, 1503–1506
R. Möller, R.D. Powell, J.F. Hainfeld, W. Fritzsche,Nano Letters, 2005,5, 7, 1475–1482
N. Zammatteo, S. Hamels, F. De Longueville, I. Alexandre, J.L. Gala, F. Brasseur, J. Remacle,Biotechnol Annu Rev, 2002,8, 85–101
C. Sonnichsen, B.M. Reinhard, J. Liphardt, A.P. Alivisatos,Nat Biotechnol, 2005,23, 6, 741–745
M.P. Sheetz, S. Turney, H. Qian, E.L. Elson,Nature, 1989,340, 6231, 284–288
K. Ritchie, X.Y. Shan, J. Kondo, K. Iwasawa, T. Fujiwara, A. Kusumi,Biophys J, 2005,88, 3, 2266–2277
A. Kusumi, Y. Sako,Curr Opin Cell Biol, 1996,8, 4, 566–574
A.J. Borgdorff, D. Choquet,Nature, 2002,417, 6889, 649–653
L. Cognet, L. Groc, B. Lounis, D. Choquet,Science’s STKE, 2006,2006, 327
L. Cognet, C. Tardin, D. Boyer, D. Choquet, P. Tamarat, B. Lounis,Proc Natl Acad Sci USA, 2003,100, 20, 11350–11355
Author information
Authors and Affiliations
Rights and permissions
Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License ( https://creativecommons.org/licenses/by-nc/2.0 ), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
About this article
Cite this article
Cognet, L., Lounis, B. Ultra-sensitive detection of individual gold nanoparticles: spectroscopy and applications to biology. Gold Bull 41, 139–146 (2008). https://doi.org/10.1007/BF03216591
Issue Date:
DOI: https://doi.org/10.1007/BF03216591