Abstract
The administration of methamphetamine to experimental animals results in damage to dopaminergic neurons. The hypothesis that methampheta-mine-induced neurotoxicity is mediated by reactive oxygen species was evaluated. It was found that acute administration of methamphetamine (5 and 15 mg kg-1) resulted in production of oxidative stress as demonstrated by decreased glutathione and increased oxidized glutathione levels in the rat striatum and prefrontal cortex. These changes in glutathione and oxidized glutathione levels were dose-dependent in striatum, but not in prefrontal cortex. In conclusion, the results of present study provide further evidence in support of the notion that oxidative stress may play an important role in the metham-phetamine-induced neurotoxicity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Agikgoz, O., Gorjeng, S., Kayatekin, B.M., Uysal, N., Pekgetin, Q, Semin, I. and Giire, A. (1998) Methamphetamine causes lipid peroxidation and an increase in superoxide dismutase activity in the rat striatum. Brain Res.813, 200–202.
Bains, J. S. and Shaw, C. A. (1997) Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-media ted neuronal death. Brain Res. Rev.25, 335–358.
Baldwin, H. A., polado, M. I., Murray, T. K., De Souza, R. J. and Green, A. R. (1993) Striatal dopamine release in vivo following neurotoxic doses of methamphetamine and effect of the neuroprotective drugs, chlormethiazole and dizocilpine. Br. J. Pharmacol108, 590–596.
Cubells, J. F., Raj-port, S., Rajendran, G. and Sulzer, D. (1994) Methamphetamine neurotoxicity involves vacualization of endocyticj organelles and dopamine-dependent intracellular oxidative stress. J. Neurosci.14, 2260–2271.
Graham, D.G. (1978) Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones. Mol. Pharmacol.14, 633–643.
LaVoie, M. J., zjigmond, M. J. and Hastings, T. G. (1996) Methamphetamine-induced neurotoxicity is associated with the formation of cysteinyl-dopamine.Soc. Neurosci. Abstr. 22, 221. (Abstract).
Li, Y., Maher, P. and Schubert, D. (1997) A role for 12-lipoxy-genase in nerve cell death caused by glutathione depletion. Neuron19, 453–463.
Moszczynska, A., Turenne, S. and Kish, S. J. (1998) Rat striatal levels of the antioxidant glutathione are decreased following binge administration of methamphetamine. Neurosci. Lett.255, 49–52.
Murphy, T. H., Schnaar, R. L. and Coyle, J. T. (1990) Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. FASEB J.4, 1624–1633.
Reynolds, I. J. and Hastings, T. G. (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci.15, 3318–3327.
Stephans, S.E. and Yamamoto, B.K. (1994) Methampheta-mine-induced neurotoxicity: roles for glutamate and dopamine efflux. Synapse17, 203–209.
Tietze, F. (1969) Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: application to mammalian blood and other tissues. Anal. Biochem.27, 502–522.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Açikgöz, O., Gönenç, S., Gezer, S. et al. Methamphetamine causes depletion of glutathione and an increase in oxidized glutathione in the rat striatum and prefrontal cortex. neurotox res 3, 277–280 (2001). https://doi.org/10.1007/BF03033266
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF03033266