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Developing yet another spinal analgesic drug?

Encore un autre analgésique rachidien ?

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References

  1. Bier A. Versuche uber cocainisirung des ruckenmarkes. Dtsch Z Chir 1899; 5151: 361.

    Article  Google Scholar 

  2. Ready LB, Plumer MH, Haschke RH, Austin E, Sumi SM. Neurotoxicity of intrathecal local anesthetics in rabbits. Anesthesiology 1985; 63: 364–70.

    Article  CAS  PubMed  Google Scholar 

  3. Rigler ML, Drasner K, Krejcie TC, et al. Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg 1991; 72: 275–81.

    Article  CAS  PubMed  Google Scholar 

  4. Schneider M, Ettlin T, Kaufmann M, et al. Transient neurologic toxicity after hyperbaric subarachnoid anesthesia with 5% lidocaine. Anesth Analg 1993; 76: 1154–7.

    Article  CAS  PubMed  Google Scholar 

  5. Pollock JE. Transient neurological symptoms: etiology, risk factors, and management. Reg Anesth Pain Med 2002; 27: 581–6.

    PubMed  Google Scholar 

  6. Beardsley D, Holman S, Gantt R, et al. Transient neurologic deficit after spinal anesthesia: local anesthetic maldistribution with pencil point needles? Anesth Analg 1995; 81: 314–20.

    CAS  PubMed  Google Scholar 

  7. Rodriguez-Chinchilla R, Rodriguez-Pont A, Pintanel T, Vidal-Lopez F. Bilateral severe pain at L3-4 after spinal anaesthesia with hyperbaric 5% lignocaine. Br J Anaesth 1996; 76: 328–9.

    Article  CAS  PubMed  Google Scholar 

  8. Lewis WR, Perrino AC Jr. Transient neurological symptoms after subarachnoid meperidine. Anesth Analg 2002; 94: 213–14.

    PubMed  Google Scholar 

  9. Hodgson PS, Neal JM, Pollock JE, Liu SS. The neurotoxicity of drugs given intrathecally (spinal). Anesth Analg 1999; 88: 797–809.

    CAS  PubMed  Google Scholar 

  10. Nishiyama T, Matsukawa T, Hanaoka K. Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. Can J Anesth 2004; 51: 899–904.

    Article  PubMed  Google Scholar 

  11. Omote K, Iwasaki H, Kawamata M, Satoh O, Namiki A. Effects of verapamil on spinal anesthesia with local anesthetics. Anesth Analg 1995; 80: 444–8.

    CAS  PubMed  Google Scholar 

  12. Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesth Analg 2003; 97: 1108–16.

    Article  CAS  PubMed  Google Scholar 

  13. Daugherty PM, Staats PS. Intrathecal drug therapy for chronic pain: from basic science to clinical practice. Anesthesiology 1999; 91: 1891–918.

    Article  Google Scholar 

  14. Kohno T, Kumamoto E, Baba H, et al. Actions of midazolam on GABAergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices. Anesthesiology 2000; 92: 507–15.

    Article  CAS  PubMed  Google Scholar 

  15. Bali M, Akabas MH. Defining the propofol binding site location on the GABAA receptor. Mol Pharmacol 2004; 65: 68–76.

    Article  CAS  PubMed  Google Scholar 

  16. van Hilten BJ, van de Beek WJ, Hoff JI, Voormolen JH, Delhaas EM. Intrathecal baclofen for the treatment of dystonia in patients with reflex sympathetic dystrophy. N Engl J Med 2000; 343: 625–30.

    Article  PubMed  Google Scholar 

  17. Bharti N, Madan R, Mohanty PR, Kaul HL. Intrathecal midazolam added to bupivacaine improves the duration and quality of spinal anaesthesia. Acta Anaesthesiol Scand 2003; 47: 1101–5.

    Article  CAS  PubMed  Google Scholar 

  18. Meythaler JM, Guin-Renfroe S, Brunner RC, Hadley MN. Intrathecal baclofen for spastic hypertonia from stroke. Stroke 2001; 32: 2099–109.

    Article  CAS  PubMed  Google Scholar 

  19. Yaksh TL, Allen JW. Preclinical insights into the implementation of intrathecal midazolam: a cautionary tale. Anesth Analg 2004; 98: 1509–11.

    Article  PubMed  Google Scholar 

  20. Coombs DW, Fratkin JD. Neurotoxicology of spinal agents. Anesthesiology 1987; 66: 724–6.

    Article  CAS  PubMed  Google Scholar 

  21. Yaksh TL, Collins JG. Studies in animals should precede human use of spinally administered drugs. Anesthesiology 1989; 70: 4–6.

    Article  CAS  PubMed  Google Scholar 

  22. Eisenach JC, Hood DD, Curry R. Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans. Anesthesiology 2002; 96: 24–8.

    Article  CAS  PubMed  Google Scholar 

  23. Hood DD, Eisenach JC, Tuttle R. Phase I safety assessment of intrathecal neostigmine methylsulfate in humans. Anesthesiology 1995; 82: 331–43.

    Article  CAS  PubMed  Google Scholar 

  24. Yaksh TL, Grafe MR, Malkmus S, Rathbun ML, Eisenach JC. Studies on the safety of chronically administered intrathecal neostigmine methylsulfate in rats and dogs. Anesthesiology 1995; 82: 412–27.

    Article  CAS  PubMed  Google Scholar 

  25. Hood DD, Eisenach JC, Tong C, Tommasi E, Yaksh TL. Cardiorespiratory and spinal cord blood flow effects of intrathecal neostigmine methylsulfate, clonidine, and their combination in sheep. Anesthesiology 1995; 82: 428–35.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Vincent Chan.

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Awad, I.T., Chan, V. Developing yet another spinal analgesic drug?. Can J Anesth 51, 871–874 (2004). https://doi.org/10.1007/BF03018882

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