Skip to main content
SpringerLink
Log in

Evaluation of tumor FDG transport and metabolism in primary central nervous system lymphoma using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) kinetic analysis

  • Original Article
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

Objective

Although18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been used as a promising tool to diagnose primary central nervous system lymphoma (PCNSL) because the tumor shows very high FDG accumulation, no data exist evaluating the extent of tumor FDG transport and metabolism. The aim of this study was to evaluate the feasibility of FDG-PET kinetic analysis in measurement of uptake parameters of FDG in the lymphoma tissues and in the assessment of treatment effects in patients with PCNSL.

Methods

Dynamic FDG-PET examination was performed in 7 histologically proven PCNSL patients before and after methotrexate-based chemotherapy.

Results

Before the chemotherapy, the highest CMRglc in the tumor for all 7 patients was 79.4 ± 27.2 μmol/100 g/min. This value was significantly higher than that observed in the normal cortex in 14 control patients (44.3 ± 6.0 μmol/100 g/min, p < 0.001). The phosphorylation (k3) activity was also significantly higher in the tumor (0.093 ± 0.026 min-1) compared with the normal cortex (0.064 ± 0.014 min-1, p < 0.05). On the other hand, the transporter (K1) activity in the tumor (0.079 ±0.016 ml/min) was similar to that observed in the normal cortex (0.082 ± 0.012 ml/min). The chemotherapy significantly reduced the volume of the tumor in 6 of 7 patients and the highest CMRglc in the tumor examined 18.0 ± 5.5 days after the chemotherapy (34.0 ±21.8 μmol/ 100 g/min) was significantly lower than that observed before the chemotherapy (p < 0.01). This reduction in FDG uptake was concomitant with a significant reduction in both the K1 and k3 values (p < 0.05). The reduction in the k3 value after the chemotherapy was marked in 6 of 7 patients in whom the tumor responded to the first chemotherapy.

Conclusions

Dynamic image acquisition can separate regional FDG uptake into FDG transport and phosphorylation activity in the lymphoma tissues. Tumor FDG uptake was significantly higher with accelerated phosphorylation activity compared with that observed in the normal cortex.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Reference

  1. Corn BW, Marcus SM, Tophan A, Hauck W, Curran WJ Jr. Will primary central nervous system lymphoma be the most frequent brain tumor diagnosed in 2000?Cancer 1997; 79:2409–2413.

    Article  PubMed  CAS  Google Scholar 

  2. Roelcke U, Leenders KL. Positron emission tomography in patients with primary CNS lymphomas.J Neuro-Oncol 1999; 43:231–236.

    Article  CAS  Google Scholar 

  3. Rosenfeld SS, Hoffman JM, Coleman RE, Glantz MJ, Hanson MW, Schold SC. Studies of primary central nervous system lymphoma with fluorine-18-fluorode-oxyglucose positron emission tomography.J Nucl Med 1992; 33:532–536.

    PubMed  CAS  Google Scholar 

  4. Wong K-P, Feng D, Meikle SR, Fulham MJ. Validation of noninvasive quantification technique for neurologic FDG-PET studies. In:Phisiological imaging of the brain with PET, Gjedde A, Hansen SB, Kundsen GM, Paulson OB (eds), San Diego; Academic Press, 2001: 121–125.

    Chapter  Google Scholar 

  5. Schaller B. Usefulness of positron emission tomography in diagnosis and treatment follow-up of brain tumors.Neurobiol Dis 2004; 15:437–448.

    Article  PubMed  CAS  Google Scholar 

  6. Spence AM, Muzi M, Graham MM, O’Sullivan F, Krohn KA, Link JM, et al. Glucose metabolism in human malignant gliomas measured quantitatively with PET, 1-[C-l l]glucose and FDG: analysis of the FDG lumped constant.J Nucl Med 1998; 39:440–448.

    PubMed  CAS  Google Scholar 

  7. Herholz K, Rudolf J, Heiss WD. FDG transport and phosphorylation in human gliomas measured with dynamic PET.J Neuro-Oncol 1992; 12:159–165.

    Article  CAS  Google Scholar 

  8. Hoekstra OS, Ossenkoppele GJ, Golding R, van Lingen A, Visser GW, Teule GJ, et al. Early treatment response in malignant lymphoma, as determined by planar fluorine-18-fluorodeoxyglucose scintigraphy.J Nucl Med 1993; 34:1706–1710.

    PubMed  CAS  Google Scholar 

  9. Romer W, Hanauske A-R, Ziegler S, Thodtmann R, Weber W, Fuchs C, et al. Positron emission tomography in non-Hodgkin’s lymphoma: assessment of chemotherapy with fluorodeoxyglucose.Blood 1998; 91:4464–4471.

    PubMed  CAS  Google Scholar 

  10. Yamane T, Daimaru O, Ito S, Yoshiya K, Nagata T, Ito S, et al. Decreases18F-FDG uptake 1 day after initiation of chemotherapy for malignant lymphoma.J Nucl Med 2004; 45:1838–1842.

    PubMed  Google Scholar 

  11. Ogawa T, Kanno I, Hatazawa J, Inugami A, Fujita H, Shimosegawa E, et al. Methionine PET for follow-up of radiation therapy of primary lymphoma of the brain.Radiographics 1994; 14:101–110.

    PubMed  CAS  Google Scholar 

  12. Kim L, Hochberg FH, Shaeffer P. White-matter abnormalities in unirradiated patients cured of primary central nervous system lymphoma.Neuroradiology 2000; 42:406–412.

    Article  PubMed  CAS  Google Scholar 

  13. Villringer K, Jager H, Dichgans M, Ziegler S, Poppinger J, Herz M, et al. Differential diagnosis of CNS lesions in AIDS patients by FDG-PET.J Comput Assist Tomogr 1995; 19:532–536.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Kagawa University School of Medicine, 1750-1 Miki-cho, 761-0793, Kita-gun, Kagawa, JAPAN

    Nobuyuki Kawai, Keisuke Miyake, Takashi Tamiya & Seigo Nagao

  2. Department of Radiology, Kagawa University School of Medicine, Japan

    Yoshihiro Nishiyama

Authors
  1. Nobuyuki Kawai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Keisuke Miyake
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takashi Tamiya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Seigo Nagao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshihiro Nishiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nobuyuki Kawai.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kawai, N., Miyake, K., Tamiya, T. et al. Evaluation of tumor FDG transport and metabolism in primary central nervous system lymphoma using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) kinetic analysis. Ann Nucl Med 19, 685–690 (2005). https://doi.org/10.1007/BF02985117

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02985117

Keywords

Search

Navigation