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Waldenström’s Macroglobulinemia Associated With AA Amyloidosis

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Abstract

It is widely accepted that amyloidosis in Waldenström’s macroglobulinemia (WM) is exclusively due to amyloid light-chain deposition. However, only a small number of previous reports have actually characterized the type of amyloid in WM.We now report the third patient with WM and amyloid A protein (AA) amyloidosis. This patient developed malabsorption, nephrotic syndrome, and orthostatic hypotension. AA was immunohistochemically demonstrated in the rectal biopsy. In conjunction with previous examples of AA amyloidosis, the present report raises the possibility that AA amyloidosis may also occur in WM patients.

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Authors and Affiliations

  1. Hematology Unit, Pathology Institute, Golda-Hasharon Campus, Rabin Medical Center and Sackler School of Medicine, Tel-Aviv University, Petah-Tikva, Israel

    J. Gardyn, U. Lewinski & A. M. Cohen

  2. Pathology Institute, Golda-Hasharon Campus, Rabin Medical Center and Sackler School of Medicine, Tel-Aviv University, Petah-Tikva, Israel

    A. Schwartz, R. Gal & D. Kristt

Authors
  1. J. Gardyn
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  2. A. Schwartz
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  3. R. Gal
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  4. U. Lewinski
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  5. D. Kristt
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  6. A. M. Cohen
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Corresponding author

Correspondence to A. M. Cohen.

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Gardyn, J., Schwartz, A., Gal, R. et al. Waldenström’s Macroglobulinemia Associated With AA Amyloidosis. Int J Hematol 74, 76–78 (2001). https://doi.org/10.1007/BF02982553

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  • DOI: https://doi.org/10.1007/BF02982553

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