Abstract
Human breast cancers frequently show allelic loss or loss of heterozygosity (LOH) at specific chromosomal regions. To understand the possible role of these genetic alterations in tumor development and progression, we examined LOH at loci on chromosomal arms lp, 3p, 11p, 13q, 16q, 18q, and 22q in 140 to 246 cases of primary breast cancers and compared it with lymph node metastasis, histological type, tumor stage, estrogen receptor (ER) and progesterone receptor (PgR) status. LOH at 1p22-31 correlated with lymph node metastasis and a tumor size of greater than 2 cm. LOH at 13ql2-14 and 18q21 were most frequently observed in tumors of the solid-tubular type. LOH at 1p34-36 was more frequent in tumors of the scirrhous and solidtubular types than in other less aggressive histological types. Furthermore, a significant association was observed between LOH at 3pl4-21, 11p11-15 and 13ql2-14 and the absence of progesterone receptors. These results suggest that some clinical characteristics of breast cancers are determined by loss of tumor suppressor genes present at specific chromosomal regions.
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Abbreviations
- LOH:
-
Loss of heterozygosity
- ER:
-
Estrogen receptor
- PgR:
-
Progesterone receptor
References
Emi M, Nakamura Y: Positional cloning of breast cancer-rerated gene.Jpn J Hum Genet 39:30, 1994.
Emi M, Miki Y, Nakamura Y: Genetic alteration and diagnosis in human breast cancer.Jpn J Hum Genet 42:34, 1997.
Emi M, Matsumoto S, Iida A: Genetic alteration in breast cancer.Jpn J Hum Genet 43, 1998. In press.
Nakamura Y: Multi-step carcinogen of colorectal cancer.Jpn J Hum Genet 38:23, 1993.
Nakamura Y: Application of DNA markers to clinical genetics.Jpn J Hum Genet 41:1–14, 1996.
Sato T, Tanigami A, Yamakawa K,et al: Alleletype of breast cancer; Cumulative allele losses promote tumor progression in primary breast cancer.Cancer Res 50:7184–7189, 1990.
Sato ?, Akiyama F, Sakamoto G,et al: Accumlation of genetic alterations and progression of primary breast cancer.Cancer Res 51:5794–5799, 1991.
Takita K, Sato T, Miyagi M,et al: Correlation of loss of alleles on the short arms of chromosomes 11 and 17 with metastasis of primary breast cancer to lymph nodes.Cancer Res 52:3914–3917, 1992.
Harada Y, Katagiri T, Ito I,et al: Genetic studies of 457 breast cancers; Clinicopathologic parameters compared with genetic alterations.Cancer 74:2281–2286, 1994.
Ito I, Yoshimoto M, Iwase T,et al: Association of genetic alterations on chromosome 17 and loss of hormone receptor in breast cancer.Br J Cancer 71: 438–441, 1995.
Tsukamoto K, Ito N, Yoshimoto M,et al: Two distinct commonly deleted regions on chromosome 13q suggest involvement of BRCA2 and retinoblastoma genes in sporadic breast carcinomas.Cancer 78:1929–1934, 1996.
lida A, Isobe R, Yoshimoto M,et al: Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22.Br J Cancer 75:264–267, 1997.
Tsukamoto K, Ito N, Yoshimoto M, et al: Allelic loss on chromosome lp is associated with progression and lymph node metastasis of primary breast cancer.Cancer, 1997. In press.
Matsumoto S, Kasumi F, Sakamoto G,et al: Detailed deletion mapping of chromosome arm 3p in breast cancers; A2-cM region on 3p 14.3-21.1 and a 5-cM region on 3p24.3-25.1 commonly deleted in tumors.Genes Chrom Cancer 20:1–7, 1997.
Nakata T, Yoshinoto M, Kasumi F, et al: Identification of a new commonly deleted region within a 2-cM interval of 11p11 in breast cancer.Eur J Cancer, 1997. In press.
Yokota T, Matsumoto S, Yoshimoto M,et al: Mapping of a breast cancer tumor suppressor gene locus to a 4-cM interval on chromosome 18q21.Jpn J Cancer Res 88:959–964, 1997.
Iida A, Kurose K, Isobe R, et al: Mapping of a new target of allelic loss to a 2-cM interval at 22ql3.1 in primary breast cancer. Genes Chrom Cancer, 1998. In press.
Murray JC, Buetow KH, Weber JL,et al: A comprehensive human linkage map with centimorgan density.Science 265:2049–2054, 1994.
Gyapay G, Morissette J, Vignai A,et al: The 1993–94 Genethon human genetic linkage map.Nat Genet 7: 246–339, 1994.
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Emi, M., Matsumoto, S., Iida, A. et al. Correlation of allelic losses and clinicopathological factors in primary breast cancers. Breast Cancer 4, 243–246 (1997). https://doi.org/10.1007/BF02966514
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DOI: https://doi.org/10.1007/BF02966514