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Expression, regulation and function of human FcεRII (CD23) antigen

  • Expression, Regulation and Function of Human CD23
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Abstract

CD23, also known as the low affinity receptor for IgE (FcεRII), belongs to a novel superfamily of type-II integral membrane proteins. FcεRII expression was originally described on B cells but subsequent studies showed that CD23 is expressed on a variety of hematopoietic cells and is regulated by several cytokines (i.e., interleukin-4, interferons) in a tissue-specific manner. In some pathological conditions such as B-chronic lymphocytic leukemia, the CD23 gene is abnormally regulated resulting in CD23 overexpression. CD23 is not only an IgE receptor but also a membrane-bound precursor of soluble molecules that still bind IgE (sCD23 or IgE-binding factors). The functions of membrane CD23 are IgE-dependent and vary according to the cell types on which it is expressed. In contrast, sCD23, in addition to being an IgE regulatory molecule, displays multiple cytokine activities that are IgE-independent.

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Authors and Affiliations

  1. Notre-Dame Hospital, Research Centre, University of Montreal, 1560 Sherbrooke Street East, H21 4M1, Montreal, Quebec, Canada

    M. Sarfati, S. Fournier, C. Y. Wu & G. Delespesse

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  1. M. Sarfati
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  2. S. Fournier
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  3. C. Y. Wu
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  4. G. Delespesse
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This work was supported by an MRC grant.

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Sarfati, M., Fournier, S., Wu, C.Y. et al. Expression, regulation and function of human FcεRII (CD23) antigen. Immunol Res 11, 260–272 (1992). https://doi.org/10.1007/BF02919132

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