Abstract
Serum cardiac troponin T (cTnT) and CKMB (mass) were analysed in three groups of patients. The first group (n=32) were patients with acute coronary syndromes including myocardial infarction. The second group (n=35)were patients with hypertension. The third group (n=24) were patients who had succumbed to non cardiac diseases. In all 3 groups, cardiac troponin T was elevated when compared with controls (p<0.001). However, CKMB elevation was not significant in all groups. CKMB levels correlated well with troponin T levels only when CKMB was greater than 50 ng/ml (r=1.00). Small elevations of troponin T identifies minimal cardiac necrosis and patients can benefit from early invasive therapy.
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Venge, P., Langerquist, B., Diderholm, E., Lindhal, B. and Wallentin, L. (2002) Clinical performance of three cardiac troponin assays in patients with unstable coronary astery disease (a FRISC II sub study).
Della Torre, P., Podesta, A., Imondi, A.R. and Moneta, D. (2001) A novel cytotoxic antitumor agent with alow cardiotoxic potential. Cancer chemother pharmacol. 47 (4): 355–360.
Aviles, R.J., Askari, A.T., Lindahl, B., Wallentin, L., Jiag, Ohman, E.M., Mahaffeg, K.W. and Newby, L.K. (2002) Troponin-T levels in patients with acute coronary syndromes with or without renal dysfunction. N. Engl. J. Med. 346 (26): 2079–2082.
Perna, Er., Macin, S.M., Parras, J.J., Pantich, R. and Farias, E.F. (2002) Cardiac troponin T levels are associated with poor short and long term prognosis in patients with acute cardiogenic pulmonary edema. N. Am Heart J. 143 (5): 814–820.
Hertmann, J., Von Birgellen, C., Haude, M. and Volbrachi, I. (2002) Prognostic implication of cardiac troponin-T increase following stent implantation. Heart 87 (6): 549–553.
Braunwald, E. (2001)Harrison's Principles of Intemal Medicine (Volume 1). 15th edition, Mc. Graw Hill, New York, U.S.A. P.1386–1399.
Licka, M., Zimmermann, R., Zenelein, S., Dengler, T.J., Katus, H.A. and Kubler, W. (2002) Troponin-T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size. Heart 87 (6): 520–524.
Marrow, D.A., Cannon, C.P., Rifai, N., Frey, M.J., Vicari, R., Lakkisn, Robertson, D.H., Hille, D.A. (2001) Ability of minor elevations of troponins-1 and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation mycocardial infarction; from a randomized trial. JAMA 286 (19): 2461–2462.
Kleimann, S., Lakki, S.N., Canon, C.P., Murphy, S.A., Dibateeiste, P.M. and Demopoulos, L.A. (2002) Prospective analysis of CK (MB) fraction and comparison with troponin-T to protect cardiac risk and benefit of an invasive strategy in patients with non-ST elevation acute coronary syndrome. J. Am. Coll. Cardial. 40 (8): 1044–1080.
Zurich, S.W., Qamer, A.U., Werdmann, M.J., Lzak, L.S., Mc Pherson, C.A. and Bernstein, L.H. (2002) Value of a single troponin—T at the time of presentation as compared to serial CK-MB determinations in patients with suspected myocardial ischemia. Clin. Chim. Acta. 326: 185–192.
Pateghini, M., Cuccia, C., Pagani, F., Turla, C., Bonetti, G. and Bonini, E. (2002) Coronary angiographic findings in patients with clinical unstable angina according to cardiac tropnin I and T concentrations in serum. Arch. Pathol. Lab. Med. 126 (4): 451.
Lindahl, B., Dedi Holm, E., LagerqVist, B., Venge, P. and Wallentin, L.J. (2001) Mechanism behind the prognostic value of troponin-T in unstable coronary artery diseases:a FRISC II substudy. J. Am. Coll. Cardial. 38 (4): 979–986.
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Reddy, G.C., Kusumanjali, G., Sharada, A.H.R. et al. Cardiac troponin-T and CK-MB (mass) levels in cardiac and non cardiac disease. Indian J Clin Biochem 19, 91–94 (2004). https://doi.org/10.1007/BF02894263
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DOI: https://doi.org/10.1007/BF02894263