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Pregnancy-associated plasma protein-A and asthma

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Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is potentially a proatherosclerotic metalloproteinase and a new inflammatory marker. Investigators sought to evaluate the significance of PAPP-A in patients with asthma. Blood samples were collected from 35 patients and 20 control subjects. Serum PAPP-A was determined by enzyme-linked immunosorbent assay. PAPP-A levels of patients with asthma (8.1±5.0 mU/L) were higher than those of the control group (4.9±2.1 mU/L) (P < .01). A significant correlation was noted between serum PAPP-A concentration and asthma severity (r=.581;P < .01). Investigators concluded that PAPP-A may contribute to airway smooth muscle hyperplasia as an insulin-like growth factor-dependent insulin-like growth factor-binding protein-4 protease in patients with asthma.

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Authors and Affiliations

  1. Department of Clinical Biochemistry, Duzce University, School of Medicine, Duzce, Turkey

    Abdurrahman Coskun MD & Ozlem Yavuz MD

  2. Department of Pulmonary Medicine, Osman Gazi University School of Medicine, Eskisehir, Turkey

    Oner Balbay MD, Ali Nihat Annakkaya MD, Ismet Bulut MD & Emel Kurt MD

  3. Department of Cardiology, Turkey

    Sadik Duran MD

Authors
  1. Abdurrahman Coskun MD
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  2. Oner Balbay MD
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  3. Sadik Duran MD
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  4. Ali Nihat Annakkaya MD
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  5. Ismet Bulut MD
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  6. Ozlem Yavuz MD
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  7. Emel Kurt MD
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Correspondence to Abdurrahman Coskun MD.

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Coskun, A., Balbay, O., Duran, S. et al. Pregnancy-associated plasma protein-A and asthma. Adv Therapy 24, 362–367 (2007). https://doi.org/10.1007/BF02849905

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