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Is signal transduction modulated by an interaction between heterotrimeric G-proteins and tubulin?

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Abstract

Although it is generally accepted that tubulin plays an important role in G-protein-mediated signal transduction in a variety of systems, the mechanism of this phenomenon is not completely understood. G-protein-tubulin interaction at the cell membrane and the cytosol, and the influence of such an interaction on cellular signaling are discussed in this review article.

Because the diameter of a microtubule is 25 nm and the plasma membrane is 9–11 nm thick, it is not possible for membrane-associated tubulin to assemble into a complete microtubule in the membrane environment. However, tubulin heterodimers may be able to function in the membrane environment as individual heterodimers or as polymers arranged into short protofilaments. At the cell membrane, membrane-associated tubulin may influence hormone-receptor interaction, receptor-G-protein coupling, and G-protein-effector coupling. Structural proteins, such as tubulin, can participate in cellular signaling by communicating through physical forces. By virtue of its interaction with the submembranous network of cytoskeletal proteins, tubulin, when perturbed in one locus, can transmit large changes in conformations to other points. Thus, GTP binding to membrane-associated tubulin might lead to a conformational change in either receptors or G proteins. This may, in turn, influence the binding of an agonist to its receptor.

On the other hand, in the cell cytosol, subsequent to agonist-induced translocation of G-proteins from the membrane compartment to the cytosol, G-proteins may affect microtubule formation. In GH3 and AtT-20 cells (stably expressing TRH receptor), transiently transfected with Gqα cDNA, soluble tubulin levels decreased in Gqα-transfected GH3 and AtT-20 cells, by 33% and 52%, respectively. These results suggest that G-proteins may have a direct effect on the microtubule function in vivo.

Because tubulin and G-protein families are ubiquitous and highly conserved, an interaction between these two protein families may occur in vivo, and this, in turn, can have an impact on signal transduction. However, the physiological significance of this interaction remains to be demonstrated.

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References

  1. Rall, T. W., Sutherland, E. W., and Wasilait, W. O. (1956).J. Biol. Chem. 218, 483–488.

    PubMed  CAS  Google Scholar 

  2. Pennington, S. R. (1994).Protein Profile 1, 169–342.

    PubMed  CAS  Google Scholar 

  3. Peters, R. A. (1956).Nature 177, 426.

    Article  PubMed  CAS  Google Scholar 

  4. Mitchison, T. J. (1992).Mol. Biol. Cell. 3, 1309–1315.

    PubMed  CAS  Google Scholar 

  5. Zor, U. (1983).Endocr. Rev. 4, 1–21.

    PubMed  CAS  Google Scholar 

  6. Jesaitis, A. J. and Klotz, K. N. (1993).Eur. J. Haematol. 51, 288–293.

    Article  PubMed  CAS  Google Scholar 

  7. Omann, G. M., Allen, R. A., Bokoch, G. M., Painter, R. G., Traynor, A. E., and Sklar, L. A. (1987).Physiol. Rev. 67, 285–322.

    PubMed  CAS  Google Scholar 

  8. Aderem, A. (1992).Trends Biochem. Sci. 17, 438–443.

    Article  PubMed  CAS  Google Scholar 

  9. Ridley, A. J. (1994).BioEssays 16, 312–327.

    Article  Google Scholar 

  10. Burrin, J. M. (1994).Ann. Clin. Biochem. 31, 205–214.

    PubMed  CAS  Google Scholar 

  11. Birnbaumer L., Abramowitz, J., and Brown, A. M. (1990).Biochim. Biophys. Acta 1031, 163–224.

    PubMed  CAS  Google Scholar 

  12. Gilman, A. G. (1987).Annu. Rev. Biochem. 56, 615–649.

    Article  PubMed  CAS  Google Scholar 

  13. Gilman, A. G. (1995).Biosci. Rep. 15, 65–97.

    Article  PubMed  CAS  Google Scholar 

  14. Spiegel, A. M., Shenker, A., and Weinstein, L. S. (1992).Endocr. Rev. 13, 536–565.

    Article  PubMed  CAS  Google Scholar 

  15. Conklin, B. R. and Bourne, H. R. (1993).Cell 73, 631–641.

    Article  PubMed  CAS  Google Scholar 

  16. Rens-Domiano, S. and Hamm, H. E. (1995).FASEB J. 9, 1059–1066.

    PubMed  CAS  Google Scholar 

  17. Rodbell, M. (1992).Curr. Topics Cell. Reg. 32, 1–47.

    CAS  Google Scholar 

  18. Rodbell, M. (1995).Biosci. Rep. 15, 117–133.

    Article  PubMed  CAS  Google Scholar 

  19. Neer, E. J. (1995).Cell 80, 249–257.

    Article  PubMed  CAS  Google Scholar 

  20. Simon, M. I., Strathmann, M. P., and Gautam, N. (1991).Science 252, 802–808.

    Article  PubMed  CAS  Google Scholar 

  21. Neubig, R. R. (1994).FASEB J. 8, 939–946.

    PubMed  CAS  Google Scholar 

  22. Gudermann, T., Kalkbrenner, F., and Schultz, G. (1996).Annu. Rev. Pharmacol. Toxicol. 36, 429–459.

    PubMed  CAS  Google Scholar 

  23. Felder, C. C. (1995).FASEB J. 9, 619–625.

    PubMed  CAS  Google Scholar 

  24. Levitzki, A. and Bar-Sinai, A. (1991).Pharmacol. Ther. 50, 271–283.

    Article  PubMed  CAS  Google Scholar 

  25. Boege, F., Neumann, E., and Helmreich, J. M. (1991).Eur. J. Biochem. 199, 1–15.

    Article  PubMed  CAS  Google Scholar 

  26. Strosberg, A. D., Camoin, L., Thin, N., and Maigret, B. (1993).Drug Design Discovery 9, 199–211.

    CAS  Google Scholar 

  27. Berridge, M. J. (1993).Nature 361, 315–325.

    Article  PubMed  CAS  Google Scholar 

  28. Exton, J. H. (1994).Annu. Rev. Physiol. 56, 349–369.

    Article  PubMed  CAS  Google Scholar 

  29. Exton, J. H. (1996).Annu. Rev. Pharmacol. Toxicol. 36, 481–509.

    Article  PubMed  CAS  Google Scholar 

  30. Sternweis, P. C. and Smrcka, A. V. (1993).Ciba Foundation Symp. 176, 96–111.

    CAS  Google Scholar 

  31. Segalat, L., Elkes, D. A., and Kaplan, J. M. (1995).Science 267, 1648–1651.

    Article  PubMed  CAS  Google Scholar 

  32. Mendel, J. E., Korswagen, H. C., Liu, K. S., Hajdu-Cronin, Y. M., Simon, M. I., Plasterk, R. H., et al. (1995).Science 267, 1652–1655.

    Article  PubMed  CAS  Google Scholar 

  33. McLaughlin, S., McKinnon, P., and Margolskee, R. F. (1992).Nature 357, 563–569.

    Article  PubMed  CAS  Google Scholar 

  34. Chabre, M. and Deterre, P. (1989).Eur. J. Biochem. 179, 255–266.

    Article  PubMed  CAS  Google Scholar 

  35. Stryer, L. (1991).J. Biol. Chem. 266, 10,711–10,714.

    CAS  Google Scholar 

  36. Hargrave, P. A. and McDowell, J. H. (1992).FASEB J. 6, 2323–2331.

    PubMed  CAS  Google Scholar 

  37. Ruiz-Avila, L., McLaughlin, S. K., Wildman, D., McKinnon, P. J., Robichon, A., spickofsky, N., et al. (1995).Nature 376, 80–85.

    Article  PubMed  CAS  Google Scholar 

  38. Kolesnikov, S. S. and Margolskee, R. F. (1995).Nature 376, 85–88.

    Article  PubMed  CAS  Google Scholar 

  39. Clapham, D. E. and Neer, E. J. (1993).Nature 365, 403–406.

    Article  PubMed  CAS  Google Scholar 

  40. Sternweis, P. C. (1994).Curr. Opinion Cell Biol. 6, 198–203.

    Article  PubMed  CAS  Google Scholar 

  41. Heithier, H., Frohlich, M., Dees, C., Baumann, M., Haring, M., Gierschik, P., et al. (1992).Eur. J. Biochem. 204, 1169–1181.

    Article  PubMed  CAS  Google Scholar 

  42. Law, S. F., Manning, D., and Reisine, T. (1991).J. Biol. Chem. 266, 17,885–17,897.

    CAS  Google Scholar 

  43. Pitcher, J. A., Inglese, J., Higgins, J.E3, Arriza, J. L., Casey, P. J., Kim, C., et al. (1992).Science 257, 1264–1267.

    Article  PubMed  CAS  Google Scholar 

  44. Taussig, R., Quarmby, L. M., and Gilman, A. G. (1993).J. Biol. Chem. 268, 9–12.

    PubMed  CAS  Google Scholar 

  45. Federman, A. D., Conklin, B. R., Schrader, K. A., Reed, R. R., and Bourne, H. R. (1992).Nature 356, 159–161.

    Article  PubMed  CAS  Google Scholar 

  46. Sunahara, R. K., Dessauer, C. W., and Gilman, A. G., (1996).Annu. Rev. Pharmacol. Toxicol. 36, 461–480.

    Article  PubMed  CAS  Google Scholar 

  47. Camps, M., Carozzi, A., Schnabel, P., Scheer, A., Parker, P. J., and Gierschik, P. (1992).Nature 360, 684–686.

    Article  PubMed  CAS  Google Scholar 

  48. Katz, A., Wu, D., and Simon, M. I. (1992).Nature 360, 686–689.

    Article  PubMed  CAS  Google Scholar 

  49. Blank, J. L., Brattain, K. A., and Exton, J. H. (1992).J. Biol. Chem. 267, 23,069–23,075.

    CAS  Google Scholar 

  50. Dustin, P. (1984).Microtubules. Springer-Verlag, Berlin, pp. 1–482.

    Google Scholar 

  51. Fosket, D. E. and Morejohn, L. C. (1992).Ann. Rev. Plant Physiol. Plant Mol. Biol. 43, 201–240.

    CAS  Google Scholar 

  52. Oakley, B. R. (1992).Trends Cell Biol. 2, 1–5.

    Article  PubMed  CAS  Google Scholar 

  53. Joshi, H. C. and Cleveland, D. W. (1990).Cell Motil. Cytoskeleton 16, 159–163.

    Article  PubMed  CAS  Google Scholar 

  54. Oakley, C. E. and Oakley, B. R. (1989).Nature 338, 662–664.

    Article  PubMed  CAS  Google Scholar 

  55. Stearns, T., Evans, L., and Kirschner, M. (1991).Cell 65, 825–836.

    Article  PubMed  CAS  Google Scholar 

  56. Zheng, Y., Jung, M. K., and Oakley, B. R. (1991).Cell 65, 817–823.

    Article  PubMed  CAS  Google Scholar 

  57. Fuchs, U., Moepps, B., Maucher, H. P., and Schraudolf, H. (1993).Plant Mol. Biol. 23, 595–603.

    Article  PubMed  CAS  Google Scholar 

  58. Marschall, L. G., Jeng, R. L., Mulholland, J., and Stearns, T. (1996).J. Cell Biol. 134, 443–454.

    Article  PubMed  CAS  Google Scholar 

  59. Spang, A., Geissler, S., Grein, K., and Schiebel, E. (1996).J. Cell Biol. 134, 429–441.

    Article  PubMed  CAS  Google Scholar 

  60. Li, Q. and Joshi, H. C. (1995).J. Cell Biol. 131, 207–214.

    Article  PubMed  CAS  Google Scholar 

  61. Joshi, H. C., Monica, L., McNamara, L., and Cleveland, D. W. (1992).Nature 356, 80–83.

    Article  PubMed  CAS  Google Scholar 

  62. Felix, M.-A., Antony, C., Wright, M., and Maro, B. (1994).J. Cell Biol. 124, 19–31.

    Article  PubMed  CAS  Google Scholar 

  63. Stearns, T. and Kirschner, M. (1994).Cell 76, 623–638.

    Article  PubMed  CAS  Google Scholar 

  64. Luduena, R. F., Banerjee, A., and Khan, I. A. (1992).Curr. Opinion Cell Biol. 4, 53–57.

    Article  PubMed  CAS  Google Scholar 

  65. Burns, R. G. and Surridge, C. (1990).FEBS Lett. 271, 1–8.

    Article  PubMed  CAS  Google Scholar 

  66. Carlier, M.-F. (1982).Mol. Cell Biochem. 47, 97–113.

    Article  PubMed  CAS  Google Scholar 

  67. Carlier, M.-F. (1989).Int. Rev. Cytol. 115, 139–170.

    PubMed  CAS  Google Scholar 

  68. Caplow, M. and Shanks, J. (1996).Mol. Biol. Cell 7, 663–675.

    PubMed  CAS  Google Scholar 

  69. Erickson, H.P. and O’Brien, E.T. (1992).Annu. Rev. Biophys. Biomol. Struct. 21, 145–166.

    PubMed  CAS  Google Scholar 

  70. Purich, D. L. and Angelastro, J. M. (1994).Adv. Enzymol. Related Areas Mol. Biol. 69, 121–154.

    Article  CAS  Google Scholar 

  71. Caplow, M. (1992).Curr. Opinion Cell Biol. 4, 58–65.

    Article  PubMed  CAS  Google Scholar 

  72. Drechel, D. N. and Kirschner, M. W. (1994).Curr. Biol. 4, 1053–1061.

    Article  Google Scholar 

  73. MacRae, T. H. (1992).Biochem. Cell Biol. 70, 835–841.

    PubMed  CAS  Google Scholar 

  74. Cassimeris, L. (1993).Cell Motil. Cytoskeleton 26, 275–281.

    Article  PubMed  CAS  Google Scholar 

  75. Engelborghs, Y. (1990). In:Microtubule Proteins. Avila, J. (ed.) CRC, Boca Raton, FL, pp. 1–35.

    Google Scholar 

  76. Bayley, P. M. (1990):J. Cell Sci. 95, 329–334.

    PubMed  CAS  Google Scholar 

  77. Mandelkow, E. and Mandelkow, E.-M. (1990).Curr. Opinion Cell Biol. 2, 3–9.

    Article  PubMed  CAS  Google Scholar 

  78. Avila, J. (1990):FASEB J. 4, 3284–3290.

    PubMed  CAS  Google Scholar 

  79. Murphy, D. B. (1991).Curr. Opinion Cell Biol. 3, 43–51.

    Article  PubMed  CAS  Google Scholar 

  80. Joshi, H. C. (1993).BioEssays 15, 637–643.

    Article  PubMed  CAS  Google Scholar 

  81. Ravindra, R. and Grosvenor, C. E. (1990).Mol. Cell. Endocrinol. 71, 165–176.

    Article  PubMed  CAS  Google Scholar 

  82. McIntosh, J. R. (1994). In:Microtubules. Hyams J. S. and Lloyd, C. W. (eds.) Wiley-Liss, New York, pp. 413–434.

    Google Scholar 

  83. Jacobson, K., Sheets, E. D., and Simson, R. (1995).Science 268, 1441,1442.

    Article  PubMed  CAS  Google Scholar 

  84. Travis, J. L. and Bowser, S. S. (1990).Protoplasma 154, 184–189.

    Article  Google Scholar 

  85. Dillman, J. F., III, Dabney, L. P., and Pfister, K. K. (1996).Proc. Natl. Acad. Sci. USA 93, 141–144.

    Article  PubMed  CAS  Google Scholar 

  86. Ravindra, R., Forman, L. J., and Patel, S. A. (1996).Endocrine 4, 43–52.

    Article  CAS  Google Scholar 

  87. Ravindra, R., Kunapuli, S. P., Forman, L. J., Nagele, R. G., Foster, K. A., and Patel, S. A. (1996).J. Cell. Biochem. 61, 392–401.

    Article  PubMed  CAS  Google Scholar 

  88. Yan, K., Greene, E., Belga, F., and Rasenick, M. M. (1996).J. Neurochem. 66, 1489–1495.

    Article  PubMed  CAS  Google Scholar 

  89. Leiber, D., Jasper, J. R., Alousi, A. A., Martin, J., Bernstein, D., and Insel, P. A. (1993).J. Biol. Chem. 268, 3833–3837.

    PubMed  CAS  Google Scholar 

  90. Hamel, E. (1990). In:Microtubule Proteins. Avila, J. (ed.) CRC, Boca Raton, FL, pp. 89–191.

    Google Scholar 

  91. Hamel, E. (1996).Med. Res. Rev. 16, 207–231.

    Article  PubMed  CAS  Google Scholar 

  92. Rowinsky, E. K. and Donehower, R. C. (1991).Pharmacol. Ther. 52, 35–84.

    Article  PubMed  CAS  Google Scholar 

  93. Himes, R. H. (1991).Pharmacol. Ther. 51, 257–267.

    Article  PubMed  CAS  Google Scholar 

  94. Rowinsky, E. K., Onetto, N., Canetta, R. M., and Arbuck, S. G. (1992).Sem. Oncol. 19, 646–662.

    CAS  Google Scholar 

  95. Foa, R., Norton, L., and Seidman, A. D. (1994).Int. J. Clin. Lab. Res. 24, 6–14.

    Article  PubMed  CAS  Google Scholar 

  96. Arnal, I. and Wade, R. H. (1995).Curr. Biol. 5, 900–908.

    Article  PubMed  CAS  Google Scholar 

  97. Vyas, D. M. and Kadow, J. F. (1995).Prog. Med. Chem. 32, 289–337.

    PubMed  CAS  Google Scholar 

  98. Wilson, L. and Jordan, M. A. (1994). In:Microtubules. Hyams, J. S. and Lloyd, C. W. (eds.) Wiley-Liss, New York, pp. 59–83.

    Google Scholar 

  99. Sato, H., Kato, T., Choku Takahashi, T., and Ito, T. (1982). In:Biological Functions of Microtubules and Related Structures. Sakai, H., Mohri, H., and Borisy, G. G. (eds.) Academic, New York, pp. 211–226.

    Google Scholar 

  100. Pepper, D. A. and Brinkley, B. R. (1979).J. Cell Biol. 82, 585–591.

    Article  PubMed  CAS  Google Scholar 

  101. Stephens, R. E. (1986).Biol. Cell 57, 95–110.

    PubMed  CAS  Google Scholar 

  102. Anderson, P. J. (1979).J. Biol. Chem. 254, 2168–2171.

    PubMed  CAS  Google Scholar 

  103. Feit, H., Duton, G. R., Barondes, S. H., and Shelanski, M. L. (1971).J. Cell Biol. 51, 138–147.

    Article  PubMed  CAS  Google Scholar 

  104. Thrower, D., Jordan, M. A., and Wilson, L. (1993).Methods Cell Biol. 37, 129–145.

    PubMed  CAS  Google Scholar 

  105. Gozes, I. and Littauer, U. Z. (1979).FEBS Lett. 99, 86–90.

    Article  PubMed  CAS  Google Scholar 

  106. Zisapel, N., Levi, M., and Gozes, L. (1980).J. Neurochem. 34, 26–32.

    Article  PubMed  CAS  Google Scholar 

  107. Ravindra, R., Nagele, R. G., Patel, S. A., and Freeman, T. A. (1994).NeuroReport 5, 1653–1656.

    Article  PubMed  CAS  Google Scholar 

  108. Burns, R. G., Farrell, K. W., and Surridge, C. D. (1993).Ciba Foundation Symp. 176, 248–267.

    CAS  Google Scholar 

  109. Sternlicht, H., Yaffe, M. B., and Farr, G. W. (1987).FEBS Lett. 214, 226–235.

    Article  PubMed  CAS  Google Scholar 

  110. Scaife, R. M., Wilson, L., and Purich, D. L. (1992).Biochemistry 31, 310–316.

    Article  PubMed  CAS  Google Scholar 

  111. Onali, P., Olianas, M. C., Schwartz, J. P., and Costa, E. (1983).Mol. Pharmacol. 24, 380–386.

    PubMed  CAS  Google Scholar 

  112. Ravindra, R. and Aronstam, R. S. (1990).Biochem. Pharmacol. 40, 457–463.

    Article  PubMed  CAS  Google Scholar 

  113. Cassel, D. and Selinger, Z. (1976).Biochim. Biophys. Acta 452, 538–551.

    PubMed  CAS  Google Scholar 

  114. Bokoch, G. M., Katada, T., Northup, J. K., Ui, M., and Gilman, A. G. (1984).J. Biol. Chem. 259, 3560–3567.

    PubMed  CAS  Google Scholar 

  115. Bond, R. A., Leff, P., Johnson, T. D., Milano, C. A., Rockman, H. A., McMinn, T. R., et al. (1995).Nature 374, 272–276.

    Article  PubMed  CAS  Google Scholar 

  116. Cherksey, B. D., Zadunaisky, J. A., and Murphy, R. B. (1980).Proc. Natl. Acad. Sci. USA 77, 6401–6405.

    Article  PubMed  CAS  Google Scholar 

  117. Schlegel, W., Kempner, E. S., and Rodbell, M. (1979).J. Biol. Chem. 254, 5168–5176.

    PubMed  CAS  Google Scholar 

  118. Rodbell, M. (1980).Nature 284, 17–22.

    Article  PubMed  CAS  Google Scholar 

  119. Coulter, S. and Rodbell, M. (1992).Proc. Natl. Acad. Sci. USA 89, 5842–5846.

    Article  PubMed  CAS  Google Scholar 

  120. Nakamura, S.-I. and Rodbell, M. (1990).Proc. Natl. Acad. Sci. USA 87, 6413–6417.

    Article  PubMed  CAS  Google Scholar 

  121. Nakamura, S.-I. and Rodbell, M. (1991).Proc. Natl. Acad. Sci. USA 88, 7150–7154.

    Article  PubMed  CAS  Google Scholar 

  122. Jahangeer, S. and Rodbell, M. (1993).Proc. Natl. Acad. Sci. USA 90, 8782–8786.

    Article  PubMed  CAS  Google Scholar 

  123. Sato, M., Kataoka, R., Dingus, J., Wilcox, M., Hildebrandt, J. D., and Lanier, S. M. (1995).J. Biol. Chem. 270, 15,269–15,276.

    CAS  Google Scholar 

  124. Sahyoon, N., LeVine, H., III, Davis, J., Hebdon, G. M., and Cuatrecasas, P. (1981).Proc. Natl. Acad. Sci. USA 78, 6158–6162.

    Article  Google Scholar 

  125. Carlson, K. E., Woolkalis, M. J., Newhouse, M. G., and Manning, D. R. (1986).Mol. Pharmacol. 30, 463–468.

    PubMed  CAS  Google Scholar 

  126. Ibarrondo, J., Joubert, D., Dufour, M. N., Cohen-Solal, A., Homburger, V., Jard, S., et al. (1995).Proc. Natl. Acad. Sci. USA 92, 8413–8417.

    Article  PubMed  CAS  Google Scholar 

  127. Vaziri, C. and Downes, C. P. (1992).J. Biol. Chem. 267, 22,973–22,981.

    CAS  Google Scholar 

  128. Offringa, R. and Bierer, B. E. (1993).J. Biol. Chem. 268, 4979–4988.

    PubMed  CAS  Google Scholar 

  129. Edelman, G. M., Yahara, I., and Wang, J. L. (1973).Proc. Natl. Acad. Sci. USA 70, 1442–1446.

    Article  PubMed  CAS  Google Scholar 

  130. Knowles, D. W., Chasis, J. A., Evans, E. A., and Mohandas, N. (1994).Biophys. J. 66, 1726–1732.

    PubMed  CAS  Google Scholar 

  131. Kirsch, J., Wolters, I., Triller, A., and Betz, H. (1993).Nature 366, 745–748.

    Article  PubMed  CAS  Google Scholar 

  132. Item, C. and Sieghart, W. (1994).J. Neurochem. 63, 1119–1125.

    Article  PubMed  CAS  Google Scholar 

  133. Whatley, V. J., Mihic, S. J., Allan, A. M., McQuilkin, S. J., and Harris, R. A. (1994).J. Biol. Chem. 269, 19,546–19,552.

    CAS  Google Scholar 

  134. Andrews, W. V., Staley, D. D., Huckle, W. R., and Conn, P. M. (1986).Endocrinology 119, 2537–2546.

    PubMed  CAS  Google Scholar 

  135. Limor, R., Schvartz, I., Hazum, E., Ayalon, D., and Naor, Z. (1989).Biochem. Biophys. Res. Commun. 159, 209–215.

    Article  PubMed  CAS  Google Scholar 

  136. Perrin, M. H., Haas, Y., Porter, J., Rivier, J., and Vale, W. (1989).Endocrinology 124, 798–804.

    PubMed  CAS  Google Scholar 

  137. Gershengorn, M. C. and Osman, R. (1996).Physiol. Rev. 76, 175–191.

    PubMed  CAS  Google Scholar 

  138. Straub, R. E. and Gershengorn, M. C. (1986).J. Biol. Chem. 261, 2712–2717.

    PubMed  CAS  Google Scholar 

  139. Lucas, D. O., Bajjalieh, S. M., Kowalchyk, J. A., and Martin, T. F. J. (1985).Biochem. Biophys. Res. Commun. 132, 721–728.

    Article  PubMed  CAS  Google Scholar 

  140. Martin, T. F. J., Lucas, D. O., Bajjalieh, S. M., and Kowalchyk, J. A. (1986).J. Biol. Chem. 261, 2918–2927.

    PubMed  CAS  Google Scholar 

  141. Taylor, R. L. and Burt, D. R. (1981).Mol. Cell.Endocrinol. 21, 85–91.

    Article  PubMed  CAS  Google Scholar 

  142. Cuatrecasas, P. (1986).The Harvey Lectures Series80, 89–128.

    Google Scholar 

  143. Ward, M. D. and Hammer, D. A. (1994).J. Math. Biol. 32, 677–704.

    Article  PubMed  CAS  Google Scholar 

  144. Conn, P. M. and Hazum, E. (1981).Endocrinology 109, 2040–2045.

    Article  PubMed  CAS  Google Scholar 

  145. Matus-Leibovitch, N., Gershengorn, M. C., and Oron, Y. (1993).Cell. Mol. Neurobiol. 13, 625–637.

    Article  PubMed  CAS  Google Scholar 

  146. Meyer zu Heringdorf, D., Liedel, K., Kaldenberg-Stasch, S., Michel, M. C., Jakobs, K. H., and Wieland, T. (1996).Eur. J. Biochem. 235, 670–676.

    Article  PubMed  CAS  Google Scholar 

  147. Sarndahl, E., Bokoch, G. M., Boulay, F., Stendahl, O., and Andersson, T. (1996).J. Biol. Chem. 271, 15,267–15,271.

    CAS  Google Scholar 

  148. Ravindra, R., McIlroy, P. J., and Patel, S. A. (1997).Pharmacol. Toxicol. 80, 24–29.

    PubMed  CAS  Google Scholar 

  149. Wunderlich, F., Muller, R., and Speth, V. (1973).Science 182, 1136–1138.

    Article  PubMed  CAS  Google Scholar 

  150. Erickson, M. A., Robinson, P., and Lisman, J. (1992).Science 257, 1255–1258.

    Article  PubMed  CAS  Google Scholar 

  151. Berstein, G., Blank, J. L., Jhon, D.-Y., Exton, J. H., Rhee, S. G., and Ross, E. M. (1992).Cell 70, 411–418.

    Article  PubMed  CAS  Google Scholar 

  152. Ravindra, R. and Aronstam, R. S. (1991).Pharmacol. Toxicol. 69, 259–262.

    PubMed  CAS  Google Scholar 

  153. Ravindra, R. and Aronstam, R. S. (1992).J. Reprod. Fertil. 95, 669–677.

    Article  PubMed  CAS  Google Scholar 

  154. Lin, C. M. and Hamel, E. (1981).J. Biol. Chem. 256, 9242–9245.

    PubMed  CAS  Google Scholar 

  155. Arai, T. and Kaziro, Y. (1977).J. Biochem. 82, 1063–1071.

    PubMed  CAS  Google Scholar 

  156. Hsieh, K. P. and Martin, T. F. J. (1992).Mol. Endocrinol. 6, 1673–1681.

    Article  PubMed  CAS  Google Scholar 

  157. Wilson, B. S., Komuro, M., and Farquhar, M. G. (1994).Endocrinology 134, 233–244.

    Article  PubMed  CAS  Google Scholar 

  158. Insel, P. A. and Kennedy, M. S. (1978).Nature 273, 471–473.

    Article  PubMed  CAS  Google Scholar 

  159. Margolis, R. and Wilson, L. (1979).Cell 18, 673–679.

    Article  PubMed  CAS  Google Scholar 

  160. Wolff, J. and Cook, G. H. (1985).Biochim. Biophys. Acta 844, 34–41.

    Article  PubMed  CAS  Google Scholar 

  161. Kennedy, M. S. and Insel, P. A. (1979).Mol. Pharmacol. 16, 215–223.

    PubMed  CAS  Google Scholar 

  162. Rudolph, S. A., Greengard, P., and Malawista, S. E. (1977).Proc. Natl. Acad. Sci. USA 74, 3404–3408.

    Article  PubMed  CAS  Google Scholar 

  163. Simantov, R. and Sachs, L. (1978).FEBS Lett. 90, 69–73.

    Article  PubMed  CAS  Google Scholar 

  164. Greene, W. C., Parker, C. M., and Parker, C. W. (1976).J. Immunol. 117, 1015–1022.

    PubMed  CAS  Google Scholar 

  165. Rasenick, M. M., Stein, P. J., and Bitensky, M. W. (1981).Nature 294, 560–562.

    Article  PubMed  CAS  Google Scholar 

  166. DoKhac, L., Tanfin, Z., and Harbon, S. (1983).Biochem. Pharmacol. 32, 2535–2541.

    Article  PubMed  CAS  Google Scholar 

  167. Cote, M., Payet, M.-D., and Gallo-Payet, N. (1997)Endocrinology 138, 69–78.

    Article  PubMed  CAS  Google Scholar 

  168. Rasenick, M. M. and Wang, N. (1988).J. Neurochem. 51, 300–311.

    Article  PubMed  CAS  Google Scholar 

  169. Hatta, S., Ozawa, H., Saito, T., and Ohshika, H. (1995).J. Neurochem. 64, 1343–1350.

    Article  PubMed  CAS  Google Scholar 

  170. Wang, N., Yan, K., and Rasenick, M. M. (1990).J. Biol. Chem. 265, 1239–1242.

    PubMed  CAS  Google Scholar 

  171. Roychowdhury, S. and Rasenick, M. M. (1994).Biochemistry 33, 9800–9805.

    Article  PubMed  CAS  Google Scholar 

  172. Popova, J. S., Johnson, G. L., and Rasenick, M. M. (1994).J. Biol. Chem. 269, 21,748–21,754.

    CAS  Google Scholar 

  173. Chabre, M. (1987).Trends Biochem. Sci. 12, 213–215.

    Article  CAS  Google Scholar 

  174. Bokoch, G. M., Bickford, K., and Elohl, B. P. (1988).J. Cell Biol. 106, 1927–1936.

    Article  PubMed  CAS  Google Scholar 

  175. Rotrosen, D., Gallin, J. I., Spiegel, A. M., and Malech, H. L. (1988).J. Biol. Chem. 263, 10,958–10,964.

    CAS  Google Scholar 

  176. Rudolph, U., Koesling, D., Hinsch, K.-D., Seifert, R., Bigalke, M., Schultz, G., et al. (1989).Mol. Cell. Endocrinol. 63, 143–153.

    Article  PubMed  CAS  Google Scholar 

  177. Muller, L., Picart, R., Barret, A., Bockaert, J., Homburger, V., and Tougard, C. (1994).Mol. Cell. Neurosci. 5, 556–566.

    Article  PubMed  CAS  Google Scholar 

  178. Milligan, G. (1993).Trends Pharm. Sci. 14, 413–418.

    Article  PubMed  CAS  Google Scholar 

  179. Wedegaertner, P. B., Bourne, H. R., and von Zastrow, M. (1996).Mol. Biol. Cell 7, 1225–1233.

    PubMed  CAS  Google Scholar 

  180. Takahashi, S., Negishi, M., and Ichikawa A. (1991).J. Biol. Chem. 266, 5367–5370.

    PubMed  CAS  Google Scholar 

  181. Negishi, M., Hashimoto, H., and Ichikawa, A. (1992).J. Biol. Chem. 267, 2367–2369.

    Google Scholar 

  182. Ransnas, L., Svoboda, P., Jasper, J., and Insel, P. A. (1989).Proc. Natl. Acad. Sci. USA 86, 7900–7903.

    Article  PubMed  CAS  Google Scholar 

  183. Ozawa, K., Takahashi, M., and Sobue, K. (1996).FEBS Lett. 382, 159–163.

    Article  PubMed  CAS  Google Scholar 

  184. Szego, C. M. and Pietras, R. J. (1984).Int. Rev. Cytol. 88, 1–302.

    PubMed  CAS  Google Scholar 

  185. Szego, C. M. (1994).Endocrine 2, 1079–1093.

    CAS  Google Scholar 

  186. Schelling, J. R., Hanson, A. S., Marzec, R., and Linas, S. L. (1992).J. Clin. Invest. 90, 2472–2480.

    PubMed  CAS  Google Scholar 

  187. Feuilloley, M., Desrues, L., and Vaudry, H. (1993).Endocrinology 133, 2319–2326.

    Article  PubMed  CAS  Google Scholar 

  188. Egan, J. J., Gronowicz, G., and Rodan, G. A. (1991).J. Cell Biol. 45, 101–111.

    CAS  Google Scholar 

  189. Lomri, A. and Marie, P. J. (1990).Bone Miner. 10, 1–12.

    Article  PubMed  CAS  Google Scholar 

  190. Lomri, A. and Marie, P. J. (1990).Biochim. Biophys. Acta 1052, 179–186.

    Article  PubMed  CAS  Google Scholar 

  191. Taniguchi, T., Takaishi, K., Murayama, T., Ito, M., Iwata, N., Chihara, K., et al. (1996).Oncogene 12, 1357–1360.

    PubMed  CAS  Google Scholar 

  192. Rybczynski, R. and Gilbert, L. I. (1995).Dev. Biol. 169, 15–28.

    Article  PubMed  CAS  Google Scholar 

  193. Lawrence, T. S., Ginzberg, R. D., Gilula, N. B., and Beers, W. H. (1979).J. Cell Biol. 80, 21–36.

    Article  PubMed  CAS  Google Scholar 

  194. Aharoni, A., Dantes, A., and Amsterdam, A. (1993).Endocrinology 133, 1426–1436.

    Article  PubMed  CAS  Google Scholar 

  195. Feuilloley, M. and Vaudry, H. (1996).Endocrine Rev. 17, 269–288.

    Article  CAS  Google Scholar 

  196. Kiley, S. C., Parker, P. J., Fabbro, D., and Jaken, S. (1992).Mol. Endocrinol. 6, 120–131.

    Article  PubMed  CAS  Google Scholar 

  197. De Moortele, S. V., Rosenbaum, E., Tixier-Vidal, A., and Tougard, C. (1991).J. Cell Sci. 99, 79–89.

    PubMed  Google Scholar 

  198. Ravindra, R., Forman, L. J., Foster, K. A., and Patel, S. A. (1995).NeuroReport 6, 1405–1408.

    Article  PubMed  CAS  Google Scholar 

  199. Wu, H. C. and Lin, C. T. (1994).Lab. Invest. 71, 175–181.

    PubMed  CAS  Google Scholar 

  200. Sandoval, I. V. and Cuatrecasas, P. (1978).Eur. J. Biochem. 91, 151–161.

    Article  PubMed  CAS  Google Scholar 

  201. Higashi, K. and Ishibashi, S. (1985).Biochem. Biophys. Res. Commun. 132, 193–197.

    Article  PubMed  CAS  Google Scholar 

  202. Geahlen, R. L. and Haley, B. E. (1979).J. Biol. Chem. 254, 11,982–11,987.

    CAS  Google Scholar 

  203. Roychowdhury, S., Wang, N., and Rasenick, M. M. (1993).Biochemistry 32, 4955–4961.

    Article  PubMed  CAS  Google Scholar 

  204. Wang, N. and Rasenick, M. M. (1991).Biochemistry 30, 10,957–10,965.

    CAS  Google Scholar 

  205. Keski-Oja, J., Lehto, V.-P., and Virtanen, I. (1981).J. Cell Biol. 90, 537–541.

    Article  PubMed  CAS  Google Scholar 

  206. Calissano, P., Monaco, G., Castellani, L., Mercanti, D., and Levi, A. (1978).Proc. Natl. Acad. Sci. USA 75, 2210–2214.

    Article  PubMed  CAS  Google Scholar 

  207. Haussinger, D., Stoll, B., vom Dahl, S., Theodoropoulos, P. A., Markogiannakis, E., Gravanis, A., et al. (1994).Biochem. Cell Biol. 72, 12–19.

    Article  PubMed  CAS  Google Scholar 

  208. Martin, S. S., Rose, D. W., Salteil, A. R., Klippel, A., Williams, L. T., and Olefsky, J. M. (1996).Endocrinology 137, 5045–5054.

    Article  PubMed  CAS  Google Scholar 

  209. Thatte, H. S., Bridges, K. R., and Golan, D. E. (1994).J. Cell. Physiol. 160, 345–357.

    Article  PubMed  CAS  Google Scholar 

  210. Hunt, R. C., Dewey, A., and Davis, A. A. (1989).J. Cell Sci. 92, 655–666.

    PubMed  CAS  Google Scholar 

  211. Spoerri, P. E. and Roisen, F. J. (1992).J. Neurosci. Res. 31, 494–501.

    Article  PubMed  CAS  Google Scholar 

  212. Olorundare, O. E., Simmons, S. R., and Albrecht, R. M. (1993).Eur. J. Cell Biol. 60, 131–145.

    PubMed  CAS  Google Scholar 

  213. Bourguignon, L. Y., Lokeshwar, V. B., Chen, X., and Kerrick, W. G. (1993).J. Immunology 151, 6634–6644.

    CAS  Google Scholar 

  214. Wang, N., Planus, E., Pouchelet, M., Fredberg, J. J., and Barlovatz-Meimon, G. (1995).Am. J. Phys. 268, C1062–1066.

    CAS  Google Scholar 

  215. van Bergen en Henegouwen, P. M. P., Defize, L. H. K., de Kroon, J., van Damme, H., Verkleij, A. J., and Boonstra, J. (1989).J. Cell. Biochem. 39, 455–465.

    Article  PubMed  Google Scholar 

  216. Ravindra, R. and Caro, J. F. (1993).J. Cell. Biochem. 53, 181–189.

    Article  PubMed  CAS  Google Scholar 

  217. Gawler, D. and Houslay, M. D. (1987).FEBS Lett. 216, 94–98.

    Article  PubMed  CAS  Google Scholar 

  218. Luttrell, L., Kilgour, E., Lamer, J., and Romero, G. (1990).J. Biol. Chem. 265, 16,873–16,879.

    CAS  Google Scholar 

  219. Baltensperger, K., Karoor, V., Paul, H., Ruoho, A., Czech, M. P., and Malbon, C. C. (1996).J. Biol. Chem. 271, 1061–1064.

    Article  PubMed  CAS  Google Scholar 

  220. Moxham, C. M. and Malbon, C. C. (1996).Nature 379, 840–844.

    Article  PubMed  CAS  Google Scholar 

  221. Daub, H., Weiss, F. U., Wallasch, C., and Ullrich, A. (1996)Nature 379, 557–560.

    Article  PubMed  CAS  Google Scholar 

  222. Velloso, L. A., Folli, F., Sun, X. J., White, M. F., Saad, M. J. A., and Kahn, C. R. (1996).Proc. Natl. Acad. Sci. USA 93, 12,490–12,495.

    Article  CAS  Google Scholar 

  223. Kemphues, K. J., Kaufman, T. C., Raff, R. A., and Raff, E. C. (1982).Cell 31, 655–670.

    Article  PubMed  CAS  Google Scholar 

  224. Boggs, B. and Cabral, F. (1987).Mol. Cell. Biol. 7, 2700–2702.

    PubMed  CAS  Google Scholar 

  225. Sisodia, S. S., Gay, D. A., and Cleveland, D. W. (1990).Nature New Biol. 2, 66–76.

    CAS  Google Scholar 

  226. Cleveland, D. W. and Theodorakis, N. G. (1994). In:Microtubules. Hyams, J. S. and Lloyd, C. W. (eds.) Wiley-Liss, New York, pp. 47–58.

    Google Scholar 

  227. Brostrom, C. O., Bocckino, S. B., and Brostrom, M. A. (1983).J. Biol. Chem. 258, 14,390–14,399.

    CAS  Google Scholar 

  228. Nurnberg, B. and Ahnert-Hilger, G. (1996).FEBS Lett. 389, 61–65.

    Article  PubMed  CAS  Google Scholar 

  229. Webb, B. C. and Wilson, L. (1980).Biochemistry 19, 1993–2000.

    Article  PubMed  CAS  Google Scholar 

  230. Pirollet, F., Job, D., Fischer, E. H., and Margolis, R. L. (1983).Proc. Natl. Acad. Sci. USA 80, 1560–1564.

    Article  PubMed  CAS  Google Scholar 

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  1. Endocrine-Metabolic Division, Veterans Affairs Medical Center, Building 1, 151, 60064, North Chicago, IL

    Rudravajhala Ravindra PhD

  2. Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL

    Rudravajhala Ravindra PhD

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Ravindra, R. Is signal transduction modulated by an interaction between heterotrimeric G-proteins and tubulin?. Endocr 7, 127–143 (1997). https://doi.org/10.1007/BF02778134

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