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Embryonic tumours of the central nervous system

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References

  1. Giangaspero RJ, Perry RH, Kelly PJ, et al. In: Kleihues. P, Cavenee WK, editors. World Health Organization Classification of Tumours; Pathology and Genetics of Tumours of the Nervous System. Lyon. (France): International Agency for Research on Cancer IARC Press; 2000. p. 123–39.

    Google Scholar 

  2. Strother DR, Pollack IF, Fisher PG, et al. Tumors of the central nervous system. In: Pizzo PA, Poplack DG, editors. Principles and Practice of Pediatric Oncology. Philadelphia PA: Lippincott Williams and Wilkins; 2002. p. 751–824.

    Google Scholar 

  3. Kühl J, Doz F, Taylor R. En: Walker DA, Perilongo G, Punt JAG, Taylor RE, editors. Brain and spinal tumors of childhood Arnold. Oxford University Press Inc; 2004. p. 331–44.

  4. Steliarova Foucher E, Stiller CH, Kaatssch, et al. Geographical patterns and time trends of cancer incidence and survival among children and adolescents in Europe since the 1970s (the ACCIS project): an epidemiological study. Lancet. 2004;364:2097–105.

    Article  PubMed  Google Scholar 

  5. Peris Bonet R, Giner Ripoll B, García Cano A. Registro Nacional de Tumores Infantiles (RNTI-SEOP). Estadísticas básicas 4. 1980–2001, Supervivencia 1980–1997. Valencia, Universidad de Valencia: 2003.

  6. Giangaspero F, Rigobello L, Bodily M, et al. Large cell medulloblastoma: A distinct variant with highly aggressive behavior. Am J Surg Pathol. 1992;16:687–93.

    Article  PubMed  CAS  Google Scholar 

  7. Eberhart CG, Kepner JL, Goldthwait PT, et al. Histopathologic grading of medulloblastomas: A Pediatric Oncology Group Study. Cancer. 2002;94:552–60.

    Article  PubMed  Google Scholar 

  8. Eberhart CG, Burger PC. Anaplasia and grading in medulloblastomas: Brain Pathol. 2003;13:376–85.

    Article  PubMed  Google Scholar 

  9. Pomeroy SL, Tamayo P, Gaasenbeek M, et al. Prediction of central nervous System embryonal tumour outcome based on gene expression. Nature. 2002;415:436–42.

    Article  PubMed  CAS  Google Scholar 

  10. Mulhern RK, Palmer SL, Reddick WE, et al. Risk of young age for selective neurocognitive deficits in medulloblastoma are associated with White matter loss. J Clin Oncol. 2001;19:472–9.

    PubMed  CAS  Google Scholar 

  11. Carrie C, Hoffstetter S, Gomez F, et al. Impact of targeting deviations on outcome in medulloblastoma: study of the French Society of Pediatric Oncology (SFOP). Int J Radiat Oncol Biol Phys. 1999;45:435–9.

    Article  PubMed  CAS  Google Scholar 

  12. Peet AC, Leach MO, Pinkerton CR, Price P, Williams SR, Grundy RG. Proceedings of the Engineering and Physical Sciences Research Council Workshop. The development of Functional imaging in the diagnosis, management and understanding of childhood brain tumours. Pediatr Blood Cancer. 2005;44:103–13.

    Article  PubMed  CAS  Google Scholar 

  13. Chang CH, Housepian EM, Herbert C. An operative staging system and a megavoltage radiotherapeutic technique for cerebellar meduloblastoma. Radiology. 1969;93:1351–9.

    PubMed  CAS  Google Scholar 

  14. Zeltzer PM, Boyett JM, Finlay JL, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastomas in children: conclusions from the Children’s Cancer Group 921 randomized phase III study. J Clin Oncol. 1999;17:832–45.

    PubMed  CAS  Google Scholar 

  15. Fernández-Teijeiro A, Betensky RA, Sturla LM, et al. Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas. J Clin Oncol. 2004;22:994–8.

    Article  PubMed  CAS  Google Scholar 

  16. Gajjar A, Hernan R, Kocak M, et al. Clinical, histopathological and molecular markers of prognosis: Towards a new disease risk stratification for medulloblastoma. J Clin Oncol. 2004;22:984–93.

    Article  PubMed  CAS  Google Scholar 

  17. Gilbertson R, Wickramasinghe C, Hernan R, et al. Clinical and molecular stratification of disease risk in medulloblastoma. Brit J Cancer. 2001;85:705–12.

    Article  PubMed  CAS  Google Scholar 

  18. Grotzer MA, Janss AJ, Fung K, et al. TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors. J Clin Oncol. 2000;18:1027–35.

    PubMed  CAS  Google Scholar 

  19. Cvekl A Jr, Zavadil J, Birshtein BK, Grotzer MA, Cvekl A. Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene. Eur J Cancer. 2004;40(16):2525–32.

    Article  PubMed  CAS  Google Scholar 

  20. Taylor RE, Bailey CC, Robinson K, et al. Results of a randomised study of pre-radiotherapy chemotherapy vs radiotherapy alone for non-metastatic (M0–1) medulloblastoma. The SIOP/UKCCSG PNET-3 study. J Clin Oncol. 2003;21:1581–91.

    Article  PubMed  CAS  Google Scholar 

  21. Packer RJ, Goldwein J, Nicholson HS, et al. Treatment of children with medulloblastomas with reduced dose craniospinal radiation therapy and adjuvant chemotherapy: a Children’s Cancer Group Study. J Clin Oncol. 1999;17:2127–36.

    PubMed  CAS  Google Scholar 

  22. Packer RJ, Sutton LN, Elterman R, Lange B, Goldwein J, Nicholson HS. Outcome for children with medulloblastomas treated with radiation and cisplatin, CCNU and vincristine chemotherapy. J Neurosurg. 1994;81:690–8.

    Article  PubMed  CAS  Google Scholar 

  23. Grill J, Kieffer-Renaux V, Bulteau C, et al. Long term intellectual outcome in children with posterior fossa tumours according to radiation doses and volumes. Int J Radiat Oncol Biol Phys. 1999;45:137–45.

    Article  PubMed  CAS  Google Scholar 

  24. Tait DM, Thornton-Jones H, Bollom HJG, et al. Adjuvant chemotherapy for medulloblastoma: The first multicentre control trial of the International Society of Pediatric Oncology (SIOP I). Eur J Cancer. 1990;26:464–9.

    PubMed  CAS  Google Scholar 

  25. Ellison DW, Clifford SC, Gajjar A, et al. Recent advances in medulloblastoma. Eur J Ped Neurol. 2003;7:53–66.

    Article  Google Scholar 

  26. Kühl J. Modern treatment strategies in medulloblastoma. Childs Nerv Syst. 1998;14:2–5.

    Article  PubMed  Google Scholar 

  27. Kortmann RD, Kuhl J, Timmerman B, et al. Postoperative neoadjuvant chemotrerapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: Results of the German prospective randomized trial HIT’ 91. Int J Radiat Oncol Biol Phys. 2000;46:269–79.

    Article  PubMed  CAS  Google Scholar 

  28. Rood BR, Macdonald TJ, Packer RJ. Current treatment of medulloblastoma: recent advances and future challenges. Semin Oncol. 2004;31(5):666–75.

    Article  PubMed  Google Scholar 

  29. Blaney SM, Poplack DG, New cytotoxic drugs for intrathecal administration. J Neurooncol. 1998;38:219–23.

    Article  PubMed  CAS  Google Scholar 

  30. Slavc I, Schuller E, Czech T, Hainfellner JA, Seidl R, Dieckmann K. Intrathecal mafosfamide therapy for pediatric brain tumors with meningeal dissemination. J Neurooncol. 1998;38:213–8

    Article  PubMed  CAS  Google Scholar 

  31. Miralbell R, Bieri S, Huguenin P, et al. Prognostic value of cerebrospinal fluid cytology in pediatric medulloblastoma. Swis Pediatric Oncology Group. Ann Oncol. 1999;10:239–41.

    Article  PubMed  CAS  Google Scholar 

  32. Duffner PK, Horowitz ME, Krischer JP, et al. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumours. N Engl J Med. 1993;328:1725–31.

    Article  PubMed  CAS  Google Scholar 

  33. Duffner PK, Horowitz ME, Krischer JP, et al. The treatment of malignant brain tumours in infants and very young children: an update of the Pediatric Oncology Group experience. J Neuro Oncol. 1999;1:152–61.

    Article  CAS  Google Scholar 

  34. Palmer SL, Goloubeva O, Reddick WE, et al. Patterns of intellectual development among survivors of pediatric medulloblastoma. A longitudinal analysis. J Clin Oncol. 2001;19:2302–8.

    PubMed  CAS  Google Scholar 

  35. Reddy AT, Janss AJ, Phillips PC, Weiss HL, Packer RJ. Outcome for children with supratentorial primitive neuroectodermal tumors treated with surgery, radiation and chemotherapy. Cancer. 2000;88(9):2189–93.

    Article  PubMed  CAS  Google Scholar 

  36. Timmerman B, Kortmann RD, Kühl, et al. The role of radiation therapy in the treatment of supratentorial PNET in childhood: results of the prospective German brain tumor trials HIT 88/89 and 91. J Clin Oncol. 2002;20:842–9.

    Article  Google Scholar 

  37. Kalifa C, Valteau D, Pizer B, Vassal G, Grill J, Hartmann O. High dose chemotherapy in childhood brain tumours. Childs Nerv Syst. 1999;15:498–505.

    Article  PubMed  CAS  Google Scholar 

  38. Pérez A, Quintero V, González M, et al High-dose chemotherapy with autologous stem cell rescue in children with high-risk and recurrent brain tumors. An Pediatr. 2004;61(1):8–15.

    Article  Google Scholar 

  39. Chi SN, Gardner SL, Levy AS, et al. Feasibility and response to induction chemotherapy intensified with highdose methotrexate for young children with newly diagnosed high-risk disseminated medulloblastoma. J Clin Oncol. 2004;22:4881–7.

    Article  PubMed  CAS  Google Scholar 

  40. Wolden SL, Dunkel IJ, Souweidane MM, et al. Patterns of failure using a conformal radiation therapy tumor bed boost for medulloblastoma. J Clin Oncol. 2003;21:3079–83.

    Article  PubMed  Google Scholar 

  41. Rutkowski S, Bode U, Deinlein F, et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005;352:978–86.

    Article  PubMed  CAS  Google Scholar 

  42. Gilbertson RJ. Medulloblastoma: signaling a change in treatment. Lancet Oncol. 2004;5(4):209–18.

    Article  PubMed  Google Scholar 

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Correspondence to Aurora Navajas Gutiérrez.

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Gutiérrez, A.N., Álvarez, A.FT. & the CNS Tumours Working Group of the Spanish Society of Paediatric Oncology. Embryonic tumours of the central nervous system. Clin Transl Oncol 7, 219–227 (2005). https://doi.org/10.1007/BF02712821

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