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The making of an erythroid cell

Molecular control of hematopoiesis

  • Published:
Biotherapy

Abstract

The number of circulating red cells is regulated by the daily balance between two processes: the destruction of the old red cells in the liver and the generation of new cells in the bone marrow. The process during which hematopoietic stem cells generate new red cells is called erythropoiesis. This manuscript will describe the molecular mechanisms involved in the process of erythroid differentiation as we understand them today. In particular it will review how erythroid specific growth factor-receptor interactions activate specific transcription factors to turn on the expression of the genes responsible for the establishment of the erythroid phenotype.

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  1. Laboratorio di Biologia Cellulare, Istituto Superiore di Sanitá, Viale Regina Elena 299, 00161, Rome, Italy

    Anna Rita Migliaccio & Giovanni Migliaccio

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  1. Anna Rita Migliaccio
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Correspondence to Anna Rita Migliaccio.

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In writing this review we have followed the Trend in Genetics guidelines for abbreviations (1). Briefly, abbreviations in italics refer to genes while non-italic, all uppercase abbreviations refer to proteins. Gene abbreviations with only the first letter capitalized, or all letter capitalized, indicate the murine or the human gene respectively.

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Migliaccio, A.R., Migliaccio, G. The making of an erythroid cell. Biotherapy 10, 251–268 (1998). https://doi.org/10.1007/BF02678546

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