Skip to main content
SpringerLink
Log in

Breast-conservation therapy in early-stage breast cancer patients with a positive family history

  • Original Articles
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Our goal was to evaluate the role of breast-conservation therapy in early-stage breast cancer patients with a family history (FH) of breast cancer.

Methods

Between 1970 and 1994, 1324 female patients with breast cancer were treated with breast-conservation therapy at our institution. From these, we identified 985 patients with stage 0–II breast cancer and who had available information on FH status. FH was considered positive in any patient who had a relative who had been previously diagnosed with breast cancer. Disease-specific survival was calculated from the date of initial diagnosis using the Kaplan-Meier method.

Results

The stage distribution for the 985 patients was as follows: 0 in 65 (7%), I in 500 (51%), and II in 420 (43%). The median age was 50 years (range, 21–88), with a median follow-up time of 8.8 years (range, .25–29). The median tumor size was 1.5 cm. FH was positive in 31%. There were no significant differences in locoregional recurrence, distant recurrence, disease-specific survival, or incidence of contralateral breast cancer in patients with a positive FH versus patients with a negative FH.

Conclusions

Breast-conservation therapy is not contraindicated in early-stage breast cancer patients with a positive FH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Brody L, Biesecker BB. Breast cancer susceptibility genes: BrCal and BrCa2.Medicine 1998;77:208–26.

    Article  PubMed  CAS  Google Scholar 

  2. Meyn M. Ataxia telangiectasia, cancer, and the pathobiology of the ATM gene.Clin Genet 1999;55:289–304.

    Article  PubMed  CAS  Google Scholar 

  3. Kleihnes P, Schauble B, zur Hausen A, Esteve J, Ohgaki H. Tumor associated with p53 germiline mutations: a synopsis of 91 families.Am J Pathol 1997;150:1–13.

    Google Scholar 

  4. Pharoah PD, Day NE, Duffy S, Easton DF, Ponder BA. Family history and the risk of breast cancer: a systematic review and meta-analysis.Int J Cancer 1997;71:800–9.

    Article  PubMed  CAS  Google Scholar 

  5. Lynch HT, Watson P, Conway T, et al. Breast cancer family history as a risk factor for early onset breast cancer.Breast Cancer Res Treat 1988;11:263–7.

    Article  PubMed  CAS  Google Scholar 

  6. Chaudary MA, Millis RR, Bullbrook RD, Hayward JL. Family history and bilateral breast cancer.Breast Cancer Res Treat 1985;5:201–5.

    Article  PubMed  CAS  Google Scholar 

  7. Easton DF, Bishop DT, Ford D, the Breast Cancer Linkage Consortium. Breast and ovarian cancer incidence in BRCA1-mutation carriers.Am J Hum Genet 1995;56:265–71.

    PubMed  CAS  Google Scholar 

  8. Fisher B, Redmond C, Poisson R, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer.N Engl J Med 1989;320:822–8.

    Article  PubMed  CAS  Google Scholar 

  9. Veronesi U, Salvadori B, Luini A, et al. Conservation treatment of early breast cancer: long-term results of 1,232 cases treated with quadrantectomy, axillarry dissection, and radiotherapy.Ann Surg 1990;211:250–9.

    PubMed  CAS  Google Scholar 

  10. Chappuis PO, Rosenblatt J, Foulkes WD. The influence of familial and hereditary factors on the prognosis of breast cancer.Ann Oncol 1999;10:1163–70.

    Article  PubMed  CAS  Google Scholar 

  11. McCormick B, Rosen PP, Kinne D, Cox L, Yahalom J. Ductal carcinoma in situ of the breast: an analysis of local control after conservation surgery and radiotherapy.Int J Radiat Oncol Biol Phys 1991;21:289–92.

    PubMed  CAS  Google Scholar 

  12. Burke M-F, Allison R, Tripcony L. Conservative therapy of breast cancer in Queensland.Int J Radiat Oncol Biol Phys 1995;31:295–303.

    Article  PubMed  CAS  Google Scholar 

  13. Kaplan E, Meier P. Nonparametric estimation from incomplete observations.J Am Stat Assoc 1958;185:1457–1.

    Google Scholar 

  14. Haas JA, Schultz DJ, Peterson ME, Solin LJ. An analysis of age and family history on outcome after breast-conservation treatment: the University of Pennsylvania Experience.Cancer J Sci Am 1998;4:308–15.

    PubMed  CAS  Google Scholar 

  15. Chabner E, Nixon A, Gelman R, et al. Family history and treatment outcome in young women after breast-conserving surgery and radiation therapy for early-stage breast cancer.J Clin Oncol 1998; 16:2045–51.

    PubMed  CAS  Google Scholar 

  16. Brekelmans CTM, Voogd AC, Botke G, et al. Family history of breast cancer and local recurrence after breast-conserving therapy.Eur J Cancer 1999;35:620–6.

    Article  PubMed  CAS  Google Scholar 

  17. Chen LM, Mundt AJ, Powers C, Halpern HJ, Weichselbaum RR. Significance of family history in breast cancer treated with breast conservation therapy.Breast J 1996;2:238–45.

    Article  Google Scholar 

  18. Fourquet A, Campana F, Zafrani B, et al. Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow up.Int J Radiat Oncol Biol Phys 1989;17:719–25.

    PubMed  CAS  Google Scholar 

  19. Haffty BG, Reiss M, Beinfield M, Fischer D, Ward B, McKhann C. Ipsilateral breast tumor recurrence as a predictor of distant disease: implications for systemic therapy at the time of local relapse.J Clin Oncol 1996;14:52–7.

    PubMed  CAS  Google Scholar 

  20. Delouche G, Bachelot F, Premont M, Kurtz JM. Conservation treatment of early breast cancer: long term results and complications.Int J Radiat Oncol Biol Phys 1987;13:29–34.

    PubMed  CAS  Google Scholar 

  21. Kurtz JM, Amalric R, Brandone H, et al. Local recurrence after breast-conserving surgery and radiotherapy.Cancer 1989;63:1912–7.

    Article  PubMed  CAS  Google Scholar 

  22. Harrold EV, Turner BC, Marloff ET, et al. Local recurrence in the conservatively treated breast cancer patient: a correlation with age and family history.Cancer J Sci Am 1998;4:302–7.

    PubMed  CAS  Google Scholar 

  23. Anderson DE, Badzioch MD. Bilaterality in familial breast cancer patients.Cancer 1985;56:2092–8.

    Article  PubMed  CAS  Google Scholar 

  24. Fisher ER, Fisher B, Sass R, Wickerham L. Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol No. 4). XI. Bilateral breast cancer.Cancer 1984;54:3002–1.

    Article  PubMed  CAS  Google Scholar 

  25. Bernstein JL, Thompson WD, Risch N, Holford TR. The genetic epidemiology of second primary breast cancer.Am J Epidemiol 1992;136:937–48.

    PubMed  CAS  Google Scholar 

  26. Israeli D, Tartter PI, Brower ST, Mizrachy B, Bratton J. The significance of family history for patients with carcinoma of the breast.J Am Coll Surg 1994;179:29–32.

    Google Scholar 

  27. Pierce LJ, Strawderman M, Narod SA, et al. Effect of radio-therapy after breast-conserving treatment in women with breast cancer and germlineBRCA1/2 mutations.J Clin Oncol 2000; 18:3360–9.

    PubMed  CAS  Google Scholar 

  28. Robson M, Levin D, Federici M, et al. Breast conservation therapy for invasive breast cancer in Ashkenazi women with BRCA gene founder mutations.J Natl Cancer Inst 1999;91:2112–7.

    Article  PubMed  CAS  Google Scholar 

  29. Haffty BG, Harrold E, Khan AJ, et al. Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status.Lancet 2002;359:1471–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Senology Geneva University, Geneva, Switzerland

    Georges Vlastos MD

  2. Departments of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas

    Nadeem Q. Mirza MD, MPH, Funda Meric MD, Kelly K. Hunt MD, Attiqa N. Mirza MD, Frederick C. Ames MD, Henry M. Kuerer MD, PhD, Merrick I. Ross MD, Barry Feig MD, Gildy Babiera MD & S. Eva Singletary MD

  3. Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas

    Thomas A. Buchholz MD

  4. Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas

    Gabriel N. Hortobagyi MD

  5. Karmanos Cancer Center, Detroit, Michigan

    Lisa A. Newman MD

Authors
  1. Georges Vlastos MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nadeem Q. Mirza MD, MPH
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Funda Meric MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kelly K. Hunt MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Attiqa N. Mirza MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lisa A. Newman MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Frederick C. Ames MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Henry M. Kuerer MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Merrick I. Ross MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Barry Feig MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Gildy Babiera MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Thomas A. Buchholz MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Gabriel N. Hortobagyi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. S. Eva Singletary MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Eva Singletary MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vlastos, G., Mirza, N.Q., Meric, F. et al. Breast-conservation therapy in early-stage breast cancer patients with a positive family history. Annals of Surgical Oncology 9, 912–919 (2002). https://doi.org/10.1007/BF02557530

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02557530

Keywords

Search

Navigation