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Effect of garlic (Allium sativum linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol

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Lipids

Abstract

The hypocholesteremic activity of garlic was tested by incorporating freeze-dried garlic powder at 0.5, 1.0, 2.0 and 3.0% levels in an atherogenic diet fed to rats. It was observed that 0.5 and 1.0% levels were not effective whereas the other 2 levels were. The group fed 2.0% garlic powder had much lower serum cholesterol level than the one fed 3%. The increased levels of low density lipoproteins (LDL) and LDL-cholesterol in rats fed the atherogenic diet were partly reversed in rats receiving a supplement of 2% garlic powder. On a cholesterol-containing diet, high density lipoproteins (HDL) and HDL-cholesterol levels were decreased. Inclusion of garlic powder in the atherogenic diet enhanced the percentage of HDL whereas no change was observed in HDL cholesterol levels. Commercial garlic pearls (equivalent to 0.15% garlic powder in the diet) produced a significant decrease in serum and liver cholesterol levels in rats fed the atherogenic diet. On the other hand, asafoetida at 1.5% level failed to reduce the serum cholesterol levels in the cholesterol-fed rats.

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References

  1. Nadkarni, A.K. (1976) in Indian Materia Medica (Nadkarni, K.M., ed.) 3rd revised edn., pp. 65–71, Popular Prakashan (P) Ltd., Bombay, India.

    Google Scholar 

  2. Subrahmanyan, V., Krishnamurthy, K., Sreenivasamurthy, V., and Swaminathan, M. (1957) J. Sci. Ind. Res. 16C, 173–174.

    Google Scholar 

  3. Mantis, A.J., Pr. Karaioannoglou, G., Spanos, G.P., and Panetsos, A.G. (1978) Food Sci. Technol. 11, 26–28.

    Google Scholar 

  4. Chaudhury, D.S., Sreenivasamurthy, V., Jayaraj, P., Sreekantiah, K.R., and Johar, D.S. (1962) J. Ind. Med. Assoc. 39, 517–520.

    CAS  Google Scholar 

  5. Jain, R.C., and Vyas, C.R. (1975) Am. J. Clin. Nutr. 28, 684–685.

    PubMed  Google Scholar 

  6. Augusti, K.T. (1977) Ind. J. Exp. Biol. 15, 489–490.

    CAS  Google Scholar 

  7. Bordia, A.K., Joshi, H.K., Sanadhya, Y.K., and Bhu, N. (1977) Atherosclerosis 28, 155–159.

    Article  PubMed  CAS  Google Scholar 

  8. Jain, R.C. (1976) Ind. J. Med. Res. 64, 1509–1515.

    CAS  Google Scholar 

  9. Jain, R.C. (1975) Lancet 1, 1240.

    Article  PubMed  CAS  Google Scholar 

  10. Jain, R.C. (1978) Am. J. Clin. Nutr. 31, 1982–1983.

    CAS  Google Scholar 

  11. Bordia, A., Verma, S.K., Vyas, A.K., Khabya, B.L., Rathore, A.S., Bhu, N., and Bedi, H.K. (1977) Atherosclerosis 26, 379–386.

    Article  PubMed  CAS  Google Scholar 

  12. Sharma, K.K., Sharma, A.L., Dwivedi, K.K., and Sharma, P.K. (1976) Ind. J. Nutr. Dietet. 13, 7–10.

    CAS  Google Scholar 

  13. Bordia, A., and Bansal, H.C. (1973) Lancet 2, 1491–1492.

    Article  PubMed  CAS  Google Scholar 

  14. Sainani, G.S., Desai, D.B., Gorhe, N.H., Natu, S.M., Pise, D.V., and Sainani, P.G. (1979) Ind. J. Med. Res. 69, 776–780.

    CAS  Google Scholar 

  15. Jain, R.C. (1977) Am. J. Clin. Nutr. 30, 1380–1381.

    PubMed  CAS  Google Scholar 

  16. Augusti, K.T., and Mathew, P.T. (1973) Ind. J. Exp. Biol. 11, 239–241.

    CAS  Google Scholar 

  17. Hubbel, R.B., Mendel, L.B., and Wakeman, A.J. (1937) J. Nutr. 14, 273–285.

    Google Scholar 

  18. Chapman, D.G., Castillo, R., and Campbell, J.A. (1959) Can. J. Biochem. Physiol. 37, 679–686.

    PubMed  CAS  Google Scholar 

  19. Searcy, R.L., and Bergquist, L.M. (1960) Clin. Chim. Acta 5, 192–199.

    Article  PubMed  CAS  Google Scholar 

  20. Folch, J., Lees, M., and Sloane-Stanley, G.H. (1957) J. Biol. Chem. 226, 497–509.

    PubMed  CAS  Google Scholar 

  21. McDonald, H.J., and Ribeiro, L.P. (1959) Clin. Chim. Acta 4, 458–459.

    Article  PubMed  CAS  Google Scholar 

  22. Ressler, N.R., Springgate, R., and Kaufman, J. (1961) J. Chromatogr. 6, 409–415.

    CAS  Google Scholar 

  23. Warnick, G.R., and Albers, J.J. (1978) J. Lipid Res. 19, 65–76.

    PubMed  CAS  Google Scholar 

  24. Nikkila, E. (1953) Scand. J. Clin. Lab. Invest. 5, Suppl. 8, 5–101.

    CAS  Google Scholar 

  25. Barr, D.P., Russ, E.M., and Eder, H.A. (1951) Am. J. Med. 11, 480–493.

    Article  PubMed  CAS  Google Scholar 

  26. Jencks, W.P., Hyatt, M.R., Jetton, M.R., Mattingly, T.W., and Durrum, E.L. (1956) J. Clin. Invest. 35, 980–990.

    Article  PubMed  CAS  Google Scholar 

  27. Boyd, G.S., and Oliver, M.F. (1960) J. Endocrinol. 21, 25–32.

    Article  CAS  Google Scholar 

  28. Subba Rao, D., Chandrasekhara, N., Stayanarayana, M.N., and Srinivasan, M. (1970) J. Nutr. 100, 1307–1315.

    Google Scholar 

  29. Carew, T.E., Hayes, S.B., Koschinsky, T., and Steinberg, D. (1976) Lancet 1, 1315–1317.

    Article  PubMed  CAS  Google Scholar 

  30. Stein, Y., Glangeaud, M.C., Fainaru, M., and Stein, O. (1975) Biochim. Biophys. Acta 380, 106–118.

    PubMed  CAS  Google Scholar 

  31. Goldstein, J.L., and Brown, M.S. (1977) Ann. Rev. Biochem. 46, 897–930.

    Article  PubMed  CAS  Google Scholar 

  32. Bordia, A., and Arora, S.K. (1975) Ind. J. Med. Res. 63, 707–711.

    CAS  Google Scholar 

  33. Gujral, S., Bhumra, H., and Swaroop, M. (1978) Nutr. Rep. Int. 17, 183–189.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Discipline of Biochemistry and Applied Nutrition, Central Food Technological Research Institute, 570 013, Mysore, India

    V. S. Kamanna & N. Chandrasekhara

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  1. V. S. Kamanna
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  2. N. Chandrasekhara
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Kamanna, V.S., Chandrasekhara, N. Effect of garlic (Allium sativum linn) on serum lipoproteins and lipoprotein cholesterol levels in albino rats rendered hypercholesteremic by feeding cholesterol. Lipids 17, 483–488 (1982). https://doi.org/10.1007/BF02535329

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  • DOI: https://doi.org/10.1007/BF02535329

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