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Structure of four newly observed alleles of the adult β-globin gene in Mediterranean goat

Struktur von vier neu entdeckten Allelen des adulten β-Globin- Gens mediterraner Ziegen

  • XXVth IUGB Congress
  • Genetics, Evolution, Taxnomy and Wildlife Conservation
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Summary

Owing to the presence of several variants at the adult β -locus and at both α-globinloci, the Hb polymorphism in goat is remarkably complex. We recently confirmed this high polymorphism in a survey on some 400 goats from Sardinia, Egypt and Cyprus. Eight alleles at the β-adultlocus and two allelic genes at both α-globinloci have been detected by electrophoretic and Chromatographic techniques. Five of the β genes identified have been completely sequenced. Four of them produce globin chains already described in previous studies at the protein level, whereas the globin chain encoded by the remaining one was undescribed. Results at the coding and non-coding regions level provide a possible basis for further interpretations on the origin of these alleles.

Zusammenfassung

Wegen des Auftretens mehrerer Varianten am adulten β-Locus und an beiden α-Globin-Loci ist der Hämoglobin-Polymorphismus bei Ziegen sehr komplex. Wir bestätigten diesen hohen Polymorphic-Grad kürzlich in einer Untersuchung von 400 Ziegen aus Sardinien, ägypten und Zypern. Mittels elektrophoretischer und chromatographischer Methoden wurden acht Allele am adulten β-Locus und zwei allele Gene an den beiden α-Loci nachgewiesen. Fünf der identifizierten β-Gene wurden bereits vollständig sequenziert. Vier davon erzeugen Globin-Ketten, die in früheren Studien auf der Protein-Ebene bereits beschrieben wurden, während die von dem verbleibenden Gen codierte Globin-Kette zuvor noch nicht beschrieben wurde. Befunde aus den kodierenden und nicht-kodierenden Bereichen könnten die Grundlage für weiterführende Interpretationen zum Ursprung dieser Allele bilden.

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Pirastru, M., Cherchi, L., Serreri, E. et al. Structure of four newly observed alleles of the adult β-globin gene in Mediterranean goat. Zeitschrift für Jagdwissenschaft 48 (Suppl 1), 267–273 (2002). https://doi.org/10.1007/BF02192417

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