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Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat

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Summary

Two atypical neuroleptic agents, clozapine and fluperlapine, produced rapid elevations in plasma PRL concentrations that were similar in magnitude to those produced by haloperidol. However, the PRL response to clozapine or fluperlapine was of much shorter duration than that elicited by haloperidol. Clozapine, but neither fluperlapine nor haloperidol, produced a rapid increase in the activity of tuberoinfundibular dopamine (TIDA) neurons, as evidenced by an enhanced accumulation of dihydroxyphenylalanine (DOPA) in the median eminence after the inhibition of DOPA decarboxylase. The clozapine-induced increase in DOPA accumulation was evident within 30 minutes after its administration and persisted for at least 4 hours. The clozapine-induced increase in the activity of TIDA neurons may account, in part, for the abbreviated PRL response to this neuroleptic. In addition, ability to produce a short-lived increase in PRL secretion in the rat appears to be common to the atypicl neuroleptic drugs.

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Author notes

  1. Miljana Simonovic

    Present address: Illinois State Psychiatric Institute, Chicago, Ill., USA

  2. T. Koyama

    Present address: Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, Japan

  3. G. A. Gudelsky

    Present address: Departments of Psychiatry and Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA

Authors and Affiliations

  1. Departments of Psychiatry and Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA

    J. I. Koenig, Miljana Simonovic, T. Koyama, T. Ohmori & H. Y. Meltzer

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  1. G. A. Gudelsky
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  2. J. I. Koenig
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  3. Miljana Simonovic
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  4. T. Koyama
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  5. T. Ohmori
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  6. H. Y. Meltzer
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Gudelsky, G.A., Koenig, J.I., Simonovic, M. et al. Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat. J. Neural Transmission 68, 227–240 (1987). https://doi.org/10.1007/BF02098500

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  • DOI: https://doi.org/10.1007/BF02098500

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