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Recombinant human epidermal growth factor prevents sclerotherapy-induced esophageal ulcer and stricture formations in pigs

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Abstract

Human epidermal growth factor (EGF), a naturally occurring protein, has been implicated in the protection of gastrointestinal mucosal integrity. The efficacy of EGF in the prevention of sclerotherapy-induced esophageal lesions was investigated in 18 minipigs with surgically induced portal hypertension. The animals underwent five weekly sessions of sclerotherapy with polidocanol 2% and were concomitantly treated with either placebo or EGF administered either paravenously or subcutaneously. EGF significantly (P<0.05) reduced esophageal ulcerations, stricture formations, and mucosal histological damage associated with sclerotherapy. The drug was well-tolerated with no overt toxicity. These results suggest a potentially important clinical value of EGF as an adjunctive treatment with the sclerotherapy.

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Authors and Affiliations

  1. Department of Pathology, Aarhus County Hospital, Aarhus, Denmark

    Claus Orloff Juhl MD, Lone Susanne Jensen MD, PhD, Torben Steiniche MD & Effat Moussa PhD

  2. Institute of Experimental Clinical Research, University of Aarhus, DK-8000, Aarhus C, Denmark

    Claus Orloff Juhl MD, Lone Susanne Jensen MD, PhD, Torben Steiniche MD & Effat Moussa PhD

Authors
  1. Claus Orloff Juhl MD
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  2. Lone Susanne Jensen MD, PhD
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  3. Torben Steiniche MD
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  4. Effat Moussa PhD
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This study was partially funded by Gastrone Corporation, Menlo Park, California.

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Juhl, C.O., Jensen, L.S., Steiniche, T. et al. Recombinant human epidermal growth factor prevents sclerotherapy-induced esophageal ulcer and stricture formations in pigs. Digest Dis Sci 39, 393–401 (1994). https://doi.org/10.1007/BF02090214

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  • DOI: https://doi.org/10.1007/BF02090214

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