Abstract
Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.
Similar content being viewed by others
References
Kador, P. F., Kinoshita, J. H., and Sharpless, N. E., J. med. Chem.28 (1985) 841.
Gabbay, K. H., A. Rev. Med.26 (1975) 521.
Kador, P. F., Med. Res. Rev.8 (1988) 325.
Kador, P. F., Akagi, Y., Terubayashi, H., Wyman, M., and Kinoshita, J. H., Archs Ophthal.106 (1988) 1099.
Kinoshita, J. H., Invest. Ophthal.13 (1974) 713.
Kinoshita, J. H., Fukushi, S., Kador, P., and Merola, L. O., Metabolism28 (1979) 462.
Chylack, L. T., and Kinoshita, J. H., Invest. Ophthal.8 (1969) 401.
Kasai, R., Hirono, S., Chou, W.-H., Tanaka, O., and Chen, F.-H., Chem. Pharm. Bull.36 (1988) 4167.
Kasai, R., Hirono, S., Chou, W.-H., Tanaka, O., and Chen, F.-H., Chem. Pharm. Bull.39 (1991) 1871.
Aida, K., Shindo, H., Tawata, M., and Onaya, T., Planta med.53 (1987) 131.
Hayman, S., and Kinoshita, J. H., J. biol. Chem.240 (1965) 877.
Sato, S., and Kador, P. F., Biochem. Pharmac.40 (1990) 1033.
Johnson, D., and Lardy, H., in: Methods in Enzymology, vol. 10, p. 94. Eds R. W. Estabrook and M. E. Pullman. Academic Press, New York 1967.
Nishikawa, M., Tsurumi, Y., Namiki, T., Toshida, K., and Okuhara, M., J. Antibiot.40 (1987) 1394.
Triphathi, R. K., and Gottlieb, D., J. Bact.100 (1969) 310.
Varma, S. D., and Kinoshita, J. H., Biochem. Pharmac.25 (1976) 2505.
Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y., Phytochemistry23 (1984) 1885.
Varma, S. D., Mikuni, I., and Kinoshita, J. H., Science188 (1975) 1215.
O'Brien, M. M., Schofield, P. J., and Edwards, M. R., J. Neurochem.39 (1982) 810.
Srivasstava, S. K., Petrash, J. M., Sadana, J. J., Ansari, N. H., and Partridge, C. A., Curr. Eye Res.2 (1982) 407.
DeJong, K. S., Schofield, P. J., and Edwards, M. R., Biochem. J.242 (1987) 143.
Poulsom, R., Biochem. Pharmac.35 (1986) 2955.
Sato, S., and Kador, P. F., Biochem. Pharmac.40 (1990) 1033.
Varma, S. D., in: Plant Flavonoids in Biology and Medicine: Biochemical, Pharmacological, and Structure-Activity Relationships, p. 343. Eds Y. Cody, E. Middleton and J. B. Harborne. Alan R. Liss, Inc., New York 1986.
Inagaki, K., Miwa, K., Yashiro, T., and Okuda, J., Chem. Pharm. Bull.30 (1982) 3244.
Bohmont, C., Aaronson, L. M., Mann, K., and Pardini, R. S., J. nat. Produc.50 (1987) 427.
Hodnick, W. F., Kung, F. S., Roettger, W. J., Bohmont, C. W., and Pardini, R. S., Biochem. Pharmac.35 (1986) 2345.
Hodnick, W. F., Roettger, W. J., Kung, F. S., Bohmont, C. W., and Pardini, R. S., in: Plant Flavonoids in Biology and Medicine: Biochemical, Pharmacological, and Structure-Activity Relationships, p. 249. Eds V. Cody, E. Middleton, and J. B. Harborne. Alan R. Liss, Inc., New York 1986.
Hodnick, W. F., Duval, D. L., and Pardini, R. S., Biochem. Pharmac.47 (1994) 573.
Itaya, S., and Igarashi, K., Biosci. Biotech. Biochem.56 (1992) 1492.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Haraguchi, H., Ohmi, I., Masuda, H. et al. Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes. Experientia 52, 564–567 (1996). https://doi.org/10.1007/BF01969729
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01969729