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Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes

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Abstract

Astilbin and neoastilbin, dihydroflavonol rhamnosides fromEngelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against bothdl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.

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Haraguchi, H., Ohmi, I., Masuda, H. et al. Inhibition of aldose reductase by dihydroflavonols inEngelhardtia chrysolepis and effects on other enzymes. Experientia 52, 564–567 (1996). https://doi.org/10.1007/BF01969729

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  • DOI: https://doi.org/10.1007/BF01969729

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