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Antibiotic prophylaxis in vaginal hysterectomy

Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin

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Abstract

The prophylactic efficacy of three intravenous doses of cefuroxime 1,500 mg plus metronidazole 500 mg in vaginal hysterectomy was compared with placebo in a prospective double-blind randomized study. Febrile morbidity occurred in 13 of 26 patients in the placebo group and 0 of 27 patients in the study group. In a second prospective randomized study, the efficacy of intravenous ciprofloxacin (200 mg single dose) was compared with the cefuroxime plus metronidazole regimen. Febrile morbidity was found in 3 of 54 patients in the ciprofloxacin group, but in none of the 58 patients in the cefuroxime plus metronidazole group.

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Authors and Affiliations

  1. Medical Centre Leeuwarden, Henri Dunantweg 2, 8934, AD Leeuwarden, the Netherlands

    W. K. Brouwer &  K. M. Kuiper

  2. Laboratory for Public Health, Jelsumerstraat 6, 8917, EN Leeuwarden, the Netherlands

    J. A. A. Hoogkamp-Korstanje

Authors
  1. W. K. Brouwer
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  2. K. M. Kuiper
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  3. J. A. A. Hoogkamp-Korstanje
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Brouwer, W.K., Kuiper, K.M. & Hoogkamp-Korstanje, J.A.A. Antibiotic prophylaxis in vaginal hysterectomy. Pharmaceutisch Weekblad Scientific Edition 12, 292–295 (1990). https://doi.org/10.1007/BF01967836

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  • DOI: https://doi.org/10.1007/BF01967836

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