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Dissociation of obesity, hypercholesterolemia and diabetes from atherosclerosis in ob/ob mice

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  • Chimica, Biochimica
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Summary

Genetically obese, diabetic and hypercholesterolemic C57BL/6J-ob/ob mice were placed on Purina Laboratory Chow containing 2% cholesterol for up to 4 months. They developed higher plasma cholesterol levels and accumulated an increased quantity of cholesterol in the liver but failed to develop atherosclerotic lesions in the aorta as would be expected in an obese, diabetic and hypercholesterolemic human adult.

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Authors and Affiliations

  1. The Lilly Research Laboratories, Eli Lilly and Company, 46206, Indianapolis, Indiana, USA

    T. T. Yen, J. A. Allan, D. V. Pearson & M. R. Schinitsky

Authors
  1. T. T. Yen
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  2. J. A. Allan
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  3. D. V. Pearson
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  4. M. R. Schinitsky
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Additional information

Acknowledgments. We wish to thank Mr. Willis M. Overton for his excellent technical assistance.

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Yen, T.T., Allan, J.A., Pearson, D.V. et al. Dissociation of obesity, hypercholesterolemia and diabetes from atherosclerosis in ob/ob mice. Experientia 33, 995–996 (1977). https://doi.org/10.1007/BF01945927

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  • DOI: https://doi.org/10.1007/BF01945927

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