Summary
A sequential study of rat brains treated transplacentally with the neurotropic carcinogen ethylnitrosourea reveals small foci of cell proliferations from the age of 8 weeks. These lesions consist mainly of undifferentiated cells of the subependymal plate type. They occur in those areas in which gliomas develop and represent the earliest, histologically detectable, changes in the development of brain tumours.
Similar content being viewed by others
References
H. Druckrey, S. Ivankovic andR. Preussmann, Nature, Lond.210, 1378 (1966).
S. Ivankovic andH. Druckrey, Z. Krebsforsch.71, 320 (1968).
H. Druckrey, R. Preussmann, S. Ivankovic andD. Schmähl, Z. Krebsforsch.69, 103 (1967).
E. L. Jones, C. E. Searle andW. Thomas Smith, J. Path.109, 123 (1973).
A. Koestner, J. W. Swenberg andW. Wechsler, Am. J. Path.63, 37 (1971).
J. A. Swenberg, N. Clendenon, R. Denlinger andW. A. Gordon, J. natn. Cancer Inst.55, 147 (1975).
W. Wechsler, P. Kleihues, S. Matsumoto, K. J. Zülch, S. Ivankovic, R. Preussmann andH. Druckrey, Ann. N. Y. Acad. Sci.159, 360 (1969).
P. Kleihues, P. L. Lantos andP. N. Magee, Int. Rev. exp. Path.15, 153 (1976).
W. F. Blakemore, J. Anat.104, 423 (1969).
P. L. Lantos, J. neurol. Sci.17, 433 (1972).
P. N. Magee, Food Cosmet. Toxic.9, 207 (1971).
Author information
Authors and Affiliations
Additional information
Acknowledgments. We thank Dr.Helen C. Grant for her help in preparation of this manuscript andG. J. Pilkington andA. L. E. Barron for their skilful technical assistance.
Rights and permissions
About this article
Cite this article
Lantos, P.L., Cox, D.J. The origin of experimental brain tumours: A sequential study. Experientia 32, 1467–1468 (1976). https://doi.org/10.1007/BF01937439
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01937439