Zusammenfassung
Das in vorliegender Übersicht zu den genannten Themen ausgebreitete Wissen ist in ständigem und raschem Zunehmen begriffen. Bislang stellt es eine bemerkenswerte und in mancher Weise verwirrende Mischung von Beobachtungen dar, die z.T. aus experimentellen Studien unter Verwendung mannigfaltiger Techniken und verschiedener Tiergattungen, aber auch aus Untersuchungen am Menschen im gesunden und kranken Zustand gewonnen wurden. Aus dieser zunehmenden Verwirrung, die andererseits einen intensiven Stimulus für weitere Forschungsarbeit abgibt, beginnen sich inzwischen doch brauchbare Arbeitshypothesen abzuzeichnen, die für die experimentelle Physiologie ein nützliches Gerüst abgeben, an die sich auch klinische Beobachtungen halten und orientieren können. Es bedarf jedoch auch wesentlich der Einsicht, daß bei einem ständig wachsenden Gegenstand solcher Komplexität allgemeingültige Verallgemeinerungen nicht leicht zu erstellen sind und den Versuchungen einer voreiligen Täuschung widerstanden werden muß.
Summary
The field covered by this review is expanding with great rapidity. It now presents a remarkable and in some ways confusing mélange of observations, derived from experiments using a wide range of techniques, on various species of animal, and from investigations in man in health and disease. Out of this fertile muddle, intensely stimulating to research, useful hypotheses are beginning to emerge, and provide a tentative physiological framework to which clinical observations may be related. It is essential to appreciate, however, that in a growing subject of such complexity, valid generalisations are not easy to make, and the temptation to impose order prematurely must be resisted.
Literatur
Abderhalden, E.: In:E. Abderhalden, Synthese der Zellbausteine. Berlin: Springer 1912.
—— u.E. S. London: Weitere Studien über die normale Verdauung der Eiweißkörper im Magendarmkanal des Hundes. Hoppe-Seylers Z. physiol. Chem.53, 148 (1907).
Abel, J. J., L. G. Rowntree, andB. B. Turner: On the removal of diffusible substances from the circulating blood of living animals by dialysis. J. Pharmacol. exp. Ther.5, 275 (1914).
Agar, W. T., F. J. R. Hird, andG. S. Sidhu: The active absorption of amino-acids by the intestine. J. Physiol. (Lond.)121, 255 (1953).
—— —— —— The uptake of amino-acids by the intestine. Biochim. biophys. Acta (Amst.)14, 80 (1954).
—— —— —— The absorption, transfer and uptake of amino-acids by intestinal tissue. Biochim. biophys. Acta (Amst.)22, 21 (1956).
——, andM. A. Parker: The inhibition of the intestinal absorption of an amino-acid by chlortetracycline. Biochim. biophys. Acta (Amst.)30, 243 (1958).
Althausen, T. L., R. K. Doig, K. Uyeyama, andM. S. Weiden: Digestion and absorption after massive resection of the small intestine. II. Recovery of the absorptive function as shown by intestinal absorption tests in two patients and a consideration of compensatory mechanisms. Gastroenterology16, 126 (1950).
Alvarado, F.: Transport of sugars and amino acids in the intestine: evidence for a common carrier. Science15, 1010 (1966).
Anfanger, H., andR. M. Heavenrich: Amino acid tolerance tests in children. Amer. J. Dis. Child.77, 425 (1949).
Aoyagi, T., G. W. Engstrom, W. B. Evans, andW. H. J. Summerskill: Gastrointestinal urease in man. Part I. Activity of mucosal urease. Gut7, 631 (1966).
Armstrong, M. D., andK. S. Robinson: On the excretion of indole derivatives in phenylketonuria. Arch. Biochem.52, 287 (1954).
Asatoor, A. M., J. Craske, D. R. London, andM. D. Milne: Indole production in Hartnup disease. Lancet1963 I, 126.
——, andM. D. Milne: Amino acid metabolism, in cystinuria. Clin. Sci.23, 285 (1962).
Baron, D. N., C. E. Dent, H. Harris, E. W. Hart, andJ. B. Jepson: Hereditary pellagra-like skin rash with temporary cerebellar ataxia, constant renal amino-aciduria and other bizarre biochemical features. Lancet1956 II, 421.
Baylin, G. J., A. P. Sanders, J. K. Isley, W. W. Shingleton, J. C. Hymans, D. H. Johnston, andJ. M. Ruffin: I131 blood levels correlated with gastric empting determined radiographically. I. Protein test meal. Proc. Soc. exp. Biol. (N.Y.)89, 51 (1955).
Beazell, J. M.: A re-examination of the role of the stomach in the digestion of carbohydrate and protein. Amer. J. Physiol.132, 42 (1941).
Beeken, W. L.: Clearance of circulating radioactivated albumin and erythrocytes by the gastrointestinal tract of normal subjects. Gastroenterology52, 35 (1967).
Bernhart, F. W., andR. W. Schneider: A new test of liver function — the tyrosine tolerance test. Amer. J. med. Sci.205, 636 (1943).
Bessman, S. P., andK. Tada: Indicanuria in phenylketonuria. Metabolism9, 377 (1960).
Bingham, J. K., H. Newey, andD. H. Smyth: Specificity of the inhibitory effects of sugars on intestinal amino acid transfer. Biochim. biophys. Acta (Amst.)120, 314 (1966a).
—— —— —— Interaction of sugars and amino acids in intestinal transfer. Biochim. biophys. Acta (Amst.)130, 281 (1966b).
Booth, C. C.: The metabolic effects of intestinal resection in man. Postgrad. med. J.37, 725 (1961).
--, andKanaghinis: A dual mechanism of absorption of L-tryptophan. J. Physiol. (Lond.)167, 18P (1963).
Borgström, B., A. Dahlquist, G. Lundh, andJ. Sjövall: Studies of intestinal digestion and absorption in the human. J. clin. Invest.36, 1521 (1957).
Bragden, J. H.: On the composition of chyle chylomicrons. J. Lab. clin. Med.52, 564 (1958).
Brambell, F. W. R., R. Halliday, andI. G. Morris: Interference by human and bovine serum and serum protein fractions with the absorption of antibodies by suckling rats and mice. Proc. roy. Soc. B149, 1 (1958).
Brice, R. S., E. E. Owen, andM. P. Tyor: Amino acid uptake and fatty acid esterification by intestinal mucosa from patients with Whipple's disease and non-tropical sprue. Gastroenterology48, 584 (1965).
Bronk, J. R., andD. S. Parsons: The influence of thyroid gland on amino acid accumulation and protein synthesis by rat small intestinein vitro. J. Physiol. (Lond.)184, 942 (1966a).
—— Amino acid accumulation and incorporation in rat intestinein vitro. J. Physiol (Lond.)184, 950 (1966b).
Bronstein, H. D., L. J. Haeffner, andO. D. Kowlessar: The significance of gelatin tolerance in malabsorption states. Gastroenterology50, 621 (1966).
Buglia, G.: Untersuchungen über die biologische Bedeutung und den Metabolismus der Eiweißstoffe. X. Gesamtstickstoff im Harn der per os mit Fleisch oder auf intravenösem Wege mit den Verdauungsprodukten des Fleisches ernährten Tiere. Z. Biol.58, 162 (1912).
Busch, H., J. R. Davis, G. R. Honig, D. C. Anderson, P. V. Nair, andW. L. Nyhan: The uptake of a variety of amino acids into nuclear proteins of tumors and other tissues. Cancer Res.19, 1010 (1959).
Butterworth, C. E., Jr., R. Santini, Jr., andE. Perez-Santiago: The absorption of glycine and its conversion to serine in patients with sprue. J. clin. Invest.37, 20 (1958).
Cajori, F. A.: The enzyme activity of dogs' intestinal juice, and its relation to intestinal digestion. Amer. J. Physiol.104, 159 (1933).
Cathcart, E. P., andJ. B. Leathes: On the absorption of proteids from the intestine, J. Physiol. (Lond.)33, 462 (1906).
Chanarin, I., D. Rothman, andE. J. Watson-Williams: Normal formiminoglutamic acid excretion in megaloblastic anaemia in pregnancy. Lancet1963 I, 1068.
Chen, M. L., Q. R. Rogers, andA. E. Harper: Observations on protein digestionin vivo. IV. Further observations on the gastrointestinal contents of rats fed different dietary proteins. J. Nutr.76, 235 (1962).
Chinn, A. B., P. S. Lavik, L. I. Babb, G. W. Buckaloo, R. M. Stitt, andW. E. Abbott: Blood isotope levels following a test meal of I131-labeled protein. J. Lab. clin. Med.42, 377 (1953).
—— ——, andG. W. Buckaloo: Use of I131-labeled protein in the diagnosis of pancreatic insufficiency. New Engl. J. Med.247, 877 (1952).
Christensen, H. N.: Reactive sites and biological transport. Advanc. Protein Chem.15, 239 (1960).
—— Intestinal absorption with special reference to amino acids. Fed. Proc.21, 37 (1962).
Christensen, N. H., D. G. Decker, E. L. Lynch, T. M. Mackenzie, andJ. H. Powers: The conjugated, nonprotein, amino acids of plasma. V. A study of the clinical significance of peptidemia. J. clin. Invest.26, 853 (1947).
——, andD. L. Oxender: Transport of amino acids into and across cells. Amer. J. clin. Nutr.8, 131 (1960).
——, andB. A. Coyne: Effects of pyridoxal and indoleacetate on cell uptake of amino acids and potassium. J. biol. Chem.209, 413 (1954).
——, andH. Schwachman: Determination of the plasma glycine after gelatin feeding as a diagnostic procedure for pancreatic fibrosis. J. clin. Invest.28, 319 (1949).
Clark, S. L., Jr.: The ingestion of proteins and colloidal materials by columnar absorptive cells of the small intestine in suckling rats and mice. J. biophys. biochem. Cytol.5, 41 (1959).
-- Mechanisms of protein transport in the intestine and other animal cells. In:D. C. Heiner (ed.), Macromolecular aspects of protein absorption and excretion in the mammalian intestine. 50th Ross Conference on Pediatric Research, University of Utah, 1964. Published 1965 (see p. 51).
Clemetson, C. A. B., andJ. Churchman: Plasma amino-acid levels following protein ingestion by pregnant and non-pregnant subjects. J. Obstet. Gynec. Brit. Emp.62, 390 (1955).
Cohnheim, O.: Die Umwandlung des Eiweiß durch die Darmwand. Hoppe-Seylers Z. physiol. Chem.33, 451 (1901).
Coles, B. L.: In: Small Intestinal Function (report of a symposium held at the Royal Free Hospital, London, in June, 1961). Lancet1961 I, 1342.
Cooke, W. T., G. Thomas, D. Mangall, andH. Cross: Observations on the faecal excretion of total solids, nitrogen, sodium, potassium, water and fat in the steatorrhoea syndrome. Clin. Sci.12, 223 (1953).
Cordero, N., andT. H. Wilson: Comparison of transport capacity of small and large intestine. Gastroenterology41, 500 (1961).
Cori, C. F.: The absorption of glycine and d,l-alanine. Proc. Soc. exp. Biol. (N.Y.)24, 125 (1926).
Craft, I. L., R. F. Crampton, M. T. Lis, andD. M. Matthews: Intestinal absorption of L-methionine, glycine and some of their peptides in the rat. J. Physiol. (Lond.)300, 111 p. (1969).
——, andD. M. Matthews: Absorption and malabsorption of glycine and glycine peptides in man. Gut9, 425 (1968).
Crampton, R. F., D. M. Matthews, andR. Poisner: Observations on the mechanism of absorption of copper by the small intestine. J. Physiol. (Lond.)178, 111 (1965).
Crane, C. W.: Some aspects of protein digestion and absorption in health and disease. Postgrad. med. J.37, 745 (1961).
——, andA. Neuberger: The digestion and absorption of protein by normal man. Biochem. J.74, 313 (1960a).
—— Absorption and elimination of15N after administration of isotopically labelled yeast protein and yeast protein hydrolysates to adult patients with coeliac disease. I. Rate of absorption of15N yeast protein and yeast protein hydrolysate. Brit. med. J.1960bII, 815.
—— II. Elimination of isotope in the urine and faeces. Brit. med. J.1960cII, 888.
Crane, R. K.: Intestinal absorption of sugars. Physiol. Rev.40, 789 (1960).
—— Sodium-dependent transport in the intestine and other animal tissues. Fed. Proc.24, 1000 (1965).
Csáky, T. Z.: Significance of sodium ions in active intestinal transport of nonelectrolytes. Amer. J. Physiol.201, 999 (1961).
Cummins, A. J., andT. P. Almy: Studies on the relationship between motility and absorption in the human small intestine. Gastroenterology23, 179 (1953).
Curran, P. F.: Ion transport in intestine and its coupling to other transport processes. Fed. Proc.24, 993 (1965).
Davenport, H. W.: In:H. W. Davenport, Physiology of the digestive tract, 2nd edit. Chicago, Ill.: Year Book Medical Publishers, Inc. 1966 (see p. 194).
Dawson, A. M.: Protein losing enteropathy. In:J. Badenoch andB. N. Brook (ed.), Recent advances in gastroenterology. London: Churchill 1965.
Dawson, R., E. S. Holdsworth, andJ. W. G. Porter: The digestion and absorption of protein in the rat. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
Delhumeau, G., G. V. Pratt, andC. Gitler: The absorption of amino acid mixtures from the small intestine of the rat. I. Equimolar mixtures and those simulating egg albumin, casein and zein. J. Nutr.77, 52 (1962).
Dent, C. E., andG. A. Rose: Amino-acid metabolism in cystinuria. Quart. J. Med.20, 205 (1951).
——, andJ. A. Schilling: Studies on the absorption of protein the amino-acid pattern in the portal blood. Biochem. J.44, 318 (1949).
Denton, A. E., andC. A. Elvehjem: Amino acid concentration in the portal vein after ingestion of amino acid. J. biol. Chem.206, 455 (1954).
——, andC. A. Elvehjem: A new method for cannulating the portal vein of dogs. J. biol. Chem.204, 731 (1953).
Deo, M. G., andV. Ramalingaswami: Reaction of the small intestine to induced protein malnutrition in rhesus monkeys — a study of cell population kinetics in the jejunum. Gastroenterology49, 150 (1965).
Drummond, K. N., A. F. Michael, R. A. Ulstrom, andR. A. Good: The blue diaper syndrome: Familial hypercalcaemia with nephrocalcinosis and indicanuria. Amer. J. Med.37, 928 (1964).
Duthie, H. L., andJ. T. Hindmarsh: The effect of amino acids on the intestinal transport of L- and D-xylosein vitro. J. Physiol. (Lond.)187, 195 (1966).
Elsom, K. A., F. W. Chornock, andF. G. Dickey: Intubation studies of the human small intestine. XXIII. A method of determining digestive activity in any portion of the gastrointestinal tract, with some measurements of protein digestion in the stomach and small intestine. J. clin. Invest.21, 795 (1942).
Erf, L. A., andC. P. Rhoads: The glycine tolerance test in sprue and pernicious anaemia. J. clin. Invest.19, 409 (1940).
Evans, W. B., T. Aoyagi, andW. H. J. Summerskill: Gastrointestinal urease in man. Part II. Urea hydrolysis and ammonia absorption in upper and lower gut lumen and the effect of neomycin. Gut7, 635 (1966).
Ewald, C. A.: In:C. A. Ewald, Lectures on diseases of the digestive organs. Vol. I. Lectures on digestion. London: The New Sydenham Society 1891. (First published in German in 1890 and translated from the 3rd German edit.)
Ewe, K., andW. H. J. Summerskill: Transfer of ammonia in the human jejunum. J. Lab. clin. Med.65, 839 (1965).
Finch, L. R., andF. J. R. Hird: The uptake of amino acids by isolated segments of rat intestine. I. A survey of factors affecting the measurement of uptake. Biochim. biophys. Acta (Amst.)43, 268 (1960a).
—— II. A survey of affinity for uptake from rates of uptake and competition for uptake. Biochim. biophys. Acta (Amst.)43, 278 (1960b).
Fisher, R. B.: In:R. B. Fisher: Protein metabolism. London: Methuen 1954.
——, andD. S. Parsons: A preparation of surviving rat small intestine for the study of absorption. J. Physiol. (Lond.)110, 36 (1949).
Fleshler, B., J. H. Butt, andJ. D. Wismar: Absorption of glycine and L-alanine by the human jejunum. J. clin. Invest.45, 1453 (1966).
Folin, O., andW. Denis: Protein metabolism from the standpoint of blood and tissue analysis. J. biol. Chem.11, 87 (1912).
Forsyth, B. T., M. E. Shipman, andI. C. Plough: The variability of faecal nitrogen excretion with liquid and solid diets. J. Lab. clin. Med.43, 440 (1954).
Fox, M., S. Thier, L. Rosenberg, W. Kiser, andS. Segal: Evidence against a single renal transport defect in cystinuria. New Engl. J. Med.270, 556 (1964).
Frame, E. G.: The levels of individual free amino acids in the plasma of normal man at various intervals after a high-protein meal. J. clin. Invest.37, 1710 (1958).
Frazer, A. C., R. Schneider, D. B. Morgan, H. G. Sammons, andM. Hayward: In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
Free, A. H., andJ. R. Leonards: Studies on the ingestion of large quantities of protein and amino acids. J. Lab. clin. Med.29, 963 (1944).
Freeark, R. J., D. D. Kozoll, andK. A. Meyer: The use of I131-labelled albumin in the diagnosis of pancreatic disease. Surgery41, 268 (1957).
Freeman, T.: The gastrointestinal tract as a site for catabolism of plasma proteins. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Blackwell: Oxford 1964.
French, J. M., andC. W. Crane: Undernutrition, malnutrition and malabsorption after gastrectomy. In:F. A. R. Stammers andJ. A. Williams (ed.), Partial gastrectomy. London: Butterworth 1963.
Fridhandler, L., andJ. H. Quastel: Absorption of amino acids from isolated surviving intestine. Arch. Biochem.56, 424 (1955).
Frimpter, G. W.: Cystinuria: metabolism of the disulphide of cysteine and homocysteine. J. clin. Invest.42, 1956 (1963).
Fullerton, P. M., andD. S. Parsons: Absorption of sugars and water from rat intestinein vivo. Quart. J. exp. Physiol.41, 387 (1956).
Gay, M., andC. W. Crane: Digestion of protein by human subjects. Gut7, 711 (1966).
Gibson, Q. H., andG. Wiseman: Selective absorption of stereo-isomers of amino acids from loops of small intestine of the rat. Biochem. J.48, 426 (1951).
Gitler, C., andD. Martinez-Rojas: The absorption of amino-acid mixtures from the small intestine of the rat. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964
Goldberg, A., andK. Guggenheim: The digestive release of amino acids and their concentrations in the portal plasma of rats after protein feeding. Biochem. J.83, 129 (1962).
Guggenheim, K., S. Halevy, andN. Friedmann: Levels of lysine and methionine in portal blood of rats following protein feeding. Arch. Biochem.91, 6 (1960).
Gupta, J. D., A. M. Dakroury, andA. E. Harper: Observations on protein digestionin vivo. I. Rate of disappearance of ingested protein from the gastrointestinal tract. J. Nutr.64, 447 (1958).
Hardy, J. D., andJ. Schultz: Jejunal absorption of an amino acid mixture in normal and in hypoproteinaemic subjects. J. appl. Physiol.4, 789 (1952).
Heath, C. W., andH. W. Fullerton: The rate of absorption of iodide and glycine from the gastrointestinal tract in normal persons and in disease conditions, J. clin. Invest.14, 475 (1935).
Henderson, Y., andA. L. Dean: On the question of proteid synthesis in the animal body. Amer. J. Physiol.9, 386 (1903).
Heringová, A., O. Koldovsky, V. Jirsová, J. Uher, R. Noack, M. Friedrich, andG. Schenk: Proteolytic and peptidase activities of the small intestine of human fetuses. Gastroenterology51, 1023 (1966).
Hill, K. J.: Gastric development and antibody transference in the lamb, with some observations on the rat and guineapig. Quart. J. exp. Physiol.41, 421 (1956).
Hindmarsh, J. T., D. Kilby, B. Ross, andG. Wiseman: Further studies on intestinal active transport during semistarvation. J. Physiol. (Lond.)188, 207 (1967).
—— —— —— andG. Wiseman: Effect of amino acids on sugar absorption. J. Physiol. (Lond.)186, 166 (1966).
—— —— —— Studies on the active transport of D-glucose and L-histidine by rats and golden hamsters fed on a penicillinenriched diet. Brit. J. Nutr.21, 45 (1967).
Höber, R., andJ. Höber: Experiments on the absorption of organic solutes in the small intestine of rats. J. cell. comp. Physiol.10, 401 (1937).
Holman, H., W. F. Nickel Jr., andM. H. Sleisenger: Hypoproteinaemia antedating intestinal lesions, and possibly due to excessive serum protein loss into the intestine. Amer. J. Med.27, 963 (1959).
Hooft, C., J. Timmermans, J. Snoeck, I. Antener, W. Oyaert, andC. van den Hende: Methionine malabsorption in a mentally retarded child. Lancet1964II 20.
Hsia, D. Y.: In:D. Y. Hsia, Inborn errors of metabolism (2nd edit.), part I. Clinical aspects. Chicago, Ill.: Year Book Medical Publishers 1966.
Jacobs, F. A., L. J. Coen, andR. S. L. Hillman: Influence of pyridoxine, pyridoxal phosphatase, deoxypyridoxine and 2,4-dinitrophenol on methionine absorption. J. biol. Chem.235, 1372 (1960).
——, andA. H. Lang: Dynamics of amino acid transport in the intact intestine. Proc. Soc. exp. Biol. (N.Y.)118, 772 (1965).
Jeejeebhoy, K. N.: In discussion followingC. Gitler andD. Martinez-Rojas, The absorption of amino-acid mixtures from the small intestine of the rat. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
Jervis, E. L., andD. H. Smyth: The effect of concentrations of amino acids on their rate of absorption from the intestine. J. Physiol. (Lond.)149, 433 (1959).
—— —— The active transfer of D-methionine by the rat intestinein vitro. J. Physiol. (Lond.)151, 51 (1960).
Kershaw, T. G., K. D. Neame, andG. Wiseman: The effect of semistarvation on absorption by the rat small intestinein vitro andin vivo. J. Physiol. (Lond.)152, 182 (1960).
Kinney, J. M., R. M. Goldwyn, J. S. Barr Jr., andF. D. Moore: Loss of the entire jejunum and ileum and the ascending colon. Management of a patient. J. Amer. med. Ass.179, 529 (1962).
Kuroda, Y., andN. S. Gimbel: Selective disappearance of stereoisomers of amino acids from the human small intestine. J. appl. Physiol.7, 148 (1954).
Kutscher, Fr., andJ. Seemann: Zur Kenntnis der Verdauungsvorgänge im Dünndarm. I. Hoppe-Seylers Z. physiol. Chem.34, 528 (1901–1902).
Laey, P. de, C. Hooft, J. Timmermans, andJ. Snoeck: Biochemical aspects of the Hartnup disease. Part I. Results of intravenous and oral tryptophan loading tests in a case of Hartnup disease. Ann. paediat. (Basel)202, 145 (1964).
Larralde, J., P. Fernandez-Otero, andM. Gonzales: Increased active transport of glucose through the intestine during pregnancy. Nature (Lond.)209, 1356 (1966).
Larsen, P. R., J. E. Ross, andD. F. Tapley: Transport of neutral, dibasic and n-methyl-substituted amino-acids by rat intestine. Biochim. biophys. Acta (Amst.)88, 570 (1964).
Laster, L., andF. J. Ingelfinger: Intestinal absorption — aspects of structure, function and disease of the small-intestine mucosa. New Engl. J. Med.264, 1138, 1192, 1246 (1961).
——, andD. M. Matthews: Intestinal absorption and malabsorption of the amino acid analogue alpha-aminoisobutyric acid, in man. J. clin. Invest.42, 948 (1963).
Lavik, P. S., L. W. Matthews, G. W. Buckaloo, F. J. Lemm, S. S. Spector, andM. L. Friedell: Use of I131-labeled protein in the study of protein digestion and absorption in children with ans without cystic fibrosis of the pancreas. Pediatrics10, 667 (1952).
Leblond, C. P., andB. E. Walker: Renowal of cell populations. Physiol. Rev.36, 255 (1956).
Lin, E. C., H. Hagihira, andT. H. Wilson: Specificity of the transport system for neutral amino acids in the hamster intestine. Amer. J. Physiol.202, 919 (1962).
——, andT. H. Wilson: Transport of L-tyrosine by the small intestinein vitro. Amer. J. Physiol.199, 127 (1960).
Lindberg, T.: Studies on intestinal dipeptidases. Acta physiol. scand.69, Suppl. 285 (1966).
Linneweh, F., M. Ehrlich, E. H. Grant u.H. Hundeshagen: Über den Aminosäuren-Transport bei phenylketonurischer Oligophrenie. Klin. Wschr.41, 253 (1963).
Lissauer, M.: Arch. of Hyg.145 (1906). Quoted byG. Lusk, 1961, q.v.
Loewi, O.: Über Eiweißsynthese im Thierkörper. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.48, 303 (1902).
London, D. R., andT. H. Foley: Cystine metabolism in cystinuria. Clin. Sci.29, 133 (1965).
——, andS. Segal:In vitro studies on the intestinal transport of amino acids and a sugar in hypothyroid rats. Endocrinology80, 623 (1967).
Longenecker, J. B., andN. L. Hause: Relationship between plasma amino acids and composition of ingested protein. Arch. Biochem.84, 46 (1959).
Lundh, G.: Intestinal digestion and absorption after gastrectomy. Acta chir. scand., Suppl. 231 (1958).
Lusk, G.: In:G. Lusk, The elements of the science of nutrition, 4th edit. Philadelphia and London: W. B. Saunders Co. 1931 (see p. 46).
McCarthy, C. F., J. L. Borland Jr., H. J. Lynch Jr., E. E. Owen, andM. P. Tyor: Defective uptake of basic amino acids and L-cystine by intestinal mucosa of patients with cystinuria. J. clin. Invest.43, 1518 (1965).
McGee, L. C., andE. S. Emery Jr.: Rate of absorption of amino acids from the small intestine in man. Proc. Soc. exp. Biol. (N.Y.)45, 475 (1940).
Matthews, D. M.: The absorption of water-soluble vitamins. Brit. med, Bull.23, 258 (1967).
--, andC. W. Hyde: Unpublished observations (1966).
——, andL. Laster: The kinetics of intestinal active transport of five neutral amino acids. Amer. J. Physiol.208, 593 (1965a).
—— —— Competition for intestinal transport among five neutral amino acids. Amer. J. Physiol.208, 601 (1965b).
—— —— Absorption of protein digestion products: A review. Gut6, 411 (1965c).
--, andD. H. Smyth: Stereochemically specific absorption of alanine from the intestine into the bloodstream. J. Physiol. (Lond.)116, 20P (1952).
—— —— The intestinal absorption of amino-acid enantiomorphs. J. Physiol (Lond.)126, 96 (1954).
--, andG. Wiseman: Transamination by the small intestine of the rat. J. Physiol. (Lond.)120, 55P (1953).
Mellinkoff, S. M., D. J. Jenden, andM. Frankland: Postprandial serum amino acid levels in viral hepatitis. Arch. intern. Med.94, 604 (1954).
Messer, M., C. M. Anderson, andR. R. W. Townley: Peptidase activity of biopsies of the duodenal mucosa of children with and without coeiac disease. Clin. chim. Acta6, 768 (1961).
Michael, A. F., K. N. Drummond, D. Deoden, J. A. Anderson, andR. A. Good: Tryptophan metabolism in man. J. clin. Invest.43, 1730 (1964).
Milne, M. D.: Disorders of amino-acid transport. Brit. med. J.1964 I, 327.
—— Genetic disorders of intestinal amino-acid transport. In: Handbook of physiology, section 6, Alimentary canal (edit. byC. F. Code), vol. 3, p. 1309. American Physiological Society, Washington, D. C. 1968.
——, andL. W. Loughridge: The intestinal absorptive defect in cystinuria. Gut2, 323 (1961).
——, andL. W. Loughridge: The metabolic disorders in Hartnup disease. Quart. J. Med.29, 407 (1960).
Moynahan, E. J., F. R. Johnson, andR. M. H McMinn: Acrodermatitis entero-pathica: demonstration of possible intestinal enzyme defect. Proc. roy. Soc. Med.56, 300 (1963).
Nakayama, K., A. Ohtsuka, T. Kuvaishi, M. Koshibu, M. Arima, M. Fukushima, T. Nakagami, andS. Fuse: Study of digestion and absorption with radioactive isotope following gastrointestinal surgery: In: Isotopes in medicine. Geneva: United Nations 1958.
Nasset, E. S.: Role of the digestive tract in the utilisation of protein and amino acids. J. Amer. med. Ass.164, 172 (1957)
—— The nutritional significance of endogenous nitrogen secretion in non-ruminants. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
——, andA. Davenport: Canine and human gastric digestion of proteinsin vivo. J. appl. Physiol.7, 447 (1955).
——, andJ. S. Ju: Mixture of endogenous and exogenous protein in the alimentary tract. J. Nutr.74, 461 (1961).
Nathans, D., D. F. Tapley, andJ. E. Ross: Intestinal transport of amine acids studiedin vitro with L-(101I)monoiodotyrosine. Biochim. biophys. Acta (Amst.)41, 271 (1960).
Neame, K. D., andG. Wiseman: The transamination of glutamic and aspartic acids during absorption by the small intestine of the dogin vivo. J. Physiol. (Lond.)135, 442 (1957).
—— —— The alanine and oxo acid concentrations in mesenteric blood during absorption of L-glutamic acid by the small intestine of the dog, cat and rabbitin vivo. J. Physiol. (Lond.)140, 148 (1958).
Neil, M. W.: The absorption of cystine and cysteine from rat small intestine. Biochem. J.71, 118 (1959).
Neumann, P. Z., andM. Silverberg: Active copper transport in mammalian tissues — a possible role in Wilson's disease. Nature (Lond.)210, 414 (1966).
Newey, H., andD. H. Smyth: The intestinal absorption of some dipeptides. J. Physiol. (Lond.)145, 48 (1959).
—— —— Intracellular hydrolysis of dipeptides during intestinal absorption. J. Physiol. (Lond.)152, 367 (1960).
—— —— Cellular mechanisms in intestinal transfer of amino acids. J. Physiol. (Lond.)164, 527 (1962).
—— —— The transfer system for neutral amino acids in the rat small intestine. J. Physiol. (Lond.)170, 328 (1964a).
—— —— Effects of sugars on intestinal transfer of amino-acids. Nature (Lond.)202, 400 (1964b).
Nissim, J. A.: Mechanisms of intestinal absorption: the concept of a spectrum of intracellular plasma. Neture (Lond.)204, 148 (1964).
Orten, A. U.: Absorption of amino acids from an isolated loop human intestine. J. Mich. med. Soc.58, 767 (1959).
—— Intestinal phase of amino acid nutrition. Fed. Proc.22, 1103 (1963).
——, andH. W. Lee: Amino acid and nitrogen absorption kinetics in man. Fed. Proc.25, 565 (1966).
Parkins, R. A., A. Dimitriadou, andC. C. Booth: The rates and sites of absorption of131I labelled albumin and sodium131I in the rat. Clin. Sci.19, 595 (1960).
Perheentupa, J., andJ. K. Visakorpi: Protein intolerance with deficient transport of basic aminoacids. Another inborn error of metabolism. Lancet1965 II, 813.
Pion, R., G. Fauconneau, andA. Rerat: Variations in portal amino acid levels in the course of digestion in the pig. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
Pittman, F. E., andR. Pollitt: Studies of jejunal mucosal digestion of peptic-tryptic digests of wheat protein in coeliac disease. Gut7, 368 (1966).
Platt, B. S., C. R. C. Heard, andR. J. C. Stewart: The effects of protein-caloric deficiency on the gastrointestinal tract. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
Polachek, A. A., C. B. Cope, R. F. Williard, andF. W. Barnes Jr.: I131-labeled protein and fat meals in patients with chronic pancreatitis. Gastroenterology37, 38 (1959).
Prockop, D. J., H. R. Keiser, andA. Sjoerdsma: Gastrointestinal absorption and renal excretion of hydroxyproline peptides. Lancet1962 II, 527.
——, andA. Sjoerdsma: Significance of urinary hydroxyproline in man. J. clin. Invest.40, 843 (1961).
Reifenstein, E. C., Jr., F. Albright, andS. L. Wells: The accumulation, interpretation, and presentation of data pertaining to metabolic balances, notably those of calcium, phosphorus and nitrogen. J. clin. Endocr.5, 367 (1945).
Reynolds, E. H., J. F. Hallpike, B. M. Phillips, andD. M. Matthews: Reversible absorptive defects in anticonvulsant megaloblastic anaemia. J. clin. Path.18, 593 (1965).
Rhoads, J. E., A. Stengel Jr., C. Riegal, F. A. Cajori, andW. D. Frazier: The absorption of protein split products from chronic isolated colon loops. Amer. J. Physiol.125, 707 (1939).
Richmond, J., andR. H. Girdwood: Observations on amino acid absorption. Clin. Sci.22, 301 (1962).
Robinson, G. B., andB. Shaw: The hydrolysis of dipeptides by different regions of rat small intestine. Biochem. J.77, 351 (1960).
Robinson, J. W. L., F. Taminelli, J. P. Filber, andP. Magnenat:In vitro measurement of amino acid uptake by the human small intestine. Med. exp. (Basel)10, 157 (1964).
Rosenberg, I. H., A. L. Coleman, andL. E. Rosenberg: The role of sodium ion in the transport of amino acids by the small intestine. Biochim. biophys. Acta (Amst.)102, 161 (1965).
Rosenberg, L. E., andS. Downing: Transport of neutral and dibasic amino acids by human leukocytes: absence of defect in cystinuria. J. clin. Invest.44, 1382 (1965).
—— ——, andS. Segal: Cystinuria: Biochemical evidence for three genetically distinct diseases. J. clin. Invest.45, 365 (1966).
—— —— andS. Segal: Competitive inhibition of dibasic amino acid transport in rat kidney. J. biol. Chem.237, 2265 (1962).
——, andJ. M. Holland: Intestinal absorption and renal excretion of cystine and cysteine in cystinuria. New Engl. J. Med.273, 530 (1965).
——, andS. Segal: Cystinuria: Biochemical evidence for two genetically distinct diseases. J. elin. Invest.44, 1092 (1965).
Ryle, A. P.: The heterogeneity of the gastric proteinosis. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
Saint, E. G., andS. Weiden: The malabsorption syndrome. Aust. Ann. Med.1, 58 (1952).
Saunders, S. J., andK. J. Isselbacher: Intestinal absorption of amino acids. Gastroenterology50, 586 (1966).
Schedl, H. P., andJ. A. Clifton: Kinetics of L-methionine absorption from the human small intestine. J. Lab. clin. Med.62, 1011 (1963).
Scheiner, E., M. E. Shils, andP. Vanamee: Malabsorption following massive intestinal resection. Amer. J. clin. Nutr.17, 64 (1965).
Schlüssel, H., u.L. Sunder-Plassman: Zur Lokalisation der Eiweißresorption in Magen-Darmtract. Tierexperimentelle Untersuchungen mit S35-markiertem Hefeeiweiß. Klin. Wschr.31, 545 (1953).
Schofield, F. A., andH. B. Lewis: A comparative study of the metabolism of α-alanine, β-alanine, serine, and isoserine. I. Absorption from the gastrointestinal tract. J. biol. Chem.168, 439 (1947).
Schultz, S. G., andR. Zalusky: Ion transport in isolated rabbit ileum. II. The interaction between active sodium and active sugar transport. J. gen. Physiol.47, 1043 (1964).
—— —— Interaction between active sodium transport and active amino-acid transport in isolated rabbit ileum. Nature (Lond.)205, 292 (1965).
Schwartz, M., andS. Jarnum: Gastrointestinal protein loss in idiopathic (hypercatabolic) hypoproteinaemia. Lancet1959 I, 327.
Scriver, C. R.: Abnormalities of tryptophan metabolism in patient with malabsorption syndrome. J. Lab. clin. Med.58, 908 (1961).
—— Hartnup disease. A genetic modification of intestinal and renal transport of certain neutral amino acids. New Engl. J. Med.273, 530 (1965).
Segal, S., andA. Blair:In vitro effect of salicylate on aminoacid accumulation by kidney cortex sciles. Nature (Lond.)200, 139 (1963).
Sharp, G. S., S. Lassen, S. Shankman, A. F. Gebhart Jr., andJ. W. Hazlet: Studies of protein absorption using nitrogen15 as a tag. J. Nutr.58, 443 (1956).
Sheffner, A. L., J. B. Kirsner, andW. L. Palmer: Studies on amino acid excretion in man. II. Amino acids in feces. J. biol. Chem.176, 89 (1948).
—— —— —— Amino acid excretion in patients with gastrointestinal disease during ingestion of various protein supplements. Gastroenterology16, 757 (1950).
Slyke, D. D. van, andG. M. Meyer: The amino-acid nitrogen of the blood. Preliminary experiments on protein assimilation. J. biol. Chem.12, 399 (1912).
—— —— The fate of protein digestion products in the body. III. The absorption of amino acids. J. biol. Chem.16, 197 (1913–1914).
Smith, A. J., andL. B. Strang: An inborn error of metabolism with the urinary excretion of α-hydroxy-butyric acid and phenylpyruvic acid. Arch. Dis. Childh.33, 109 (1958).
Smyth, D. H.: Methods for study of intestinal absorptionin vivo. Meth. med. Res.9, 260 (1961).
—— Mechanisms for amino-acid absorption. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
--Smyth, D. H. andB. C. Whaler: Apparatus for thein vitro study of intestinal absorption. J. Physiol. (Lond.)121, 2P (1953).
Snook, J. T., andJ. H. Meyer: Factors influencing the significance of endogenous nitrogen to the non-ruminant. In:H. N. Munro (ed.), The role of the gastrointestinal tract in protein metabolism. Oxford: Blackwell 1964.
Spencer, R. P., T. M. Bow, andM. A. Markulis: Amino group requirements forin vitro intestinal transport of amino acids. Amer. J. Physiol.202, 171 (1962).
—— —— —— andK. R. Brody: Enzymatic assay and glucose and amino acid uptake of intestinal biopsy specimens. Amer. J. dig. Dis.8, 415 (1963).
——, andK. R. Brody: Intestinal transport of cyclic and noncyclic imino acids. Biochim. biophys. Acta (Amst.)88, 400 (1964).
——, andW. E. Knox: Comparative enzyme apparatus of the gut mucosa. Fed. Proc.19, 886 (1960).
——, andA. H. Samiy: Intestinal transport of L-tryptophanin vitro: inhibition by high concentrations. Amer. J. Physiol.199, 1033 (1960).
Stein, W. H., A. G. Bearn, andS. Moore: The amino acid content of the blood and urine in Wilson's disease. J. clin. Invest.33, 410 (1954).
——, andS. Moore: The free amino acids of human blood plasma. J. biol. Chem.211, 915 (1954).
Taylor, W. H.: Studies on gastric proteolysis. 1. The proteolytic activity of human gastric juice and pig and calf gastric mucosal extracts below pH 5. Biochem. J.71, 73 (1959a).
—— 3. The secretion of different pepsins by fundic pylorus glands of the stomach. Biochem. J.71, 384 (1959b).
—— Gastric proteinosis in health and disease. Gastroenterology40, 823 (1961).
——, andM. H. Power: The effect of cortisone on non-tropical sprue. Gastroenterology20, 203 (1952).
Theil, G. B., F. L. Benoit, andR. H. Watten: An oral gelatin-xylose test for estimating pancreatic proteolytic activity. Amer. J. dig. Dis.8, 1008 (1963).
Thier, S. O., M. Fox, S. Segal, andL. E. Rosenberg: Cystinuria:in vitro demonstration of an intestinal transport defect. Science143, 482 (1964).
——, andL. E. Rosenberg: Cystinuria: defective intestinal transport of dibasic amino acids and cystine. J. clin. Invest.44, 442 (1965).
Toscani, V., andG. D. Whedon: Nitrogen loss in the faeces: the variability of excretion in normal subjects on constant dietary intakes. J. Nutr.45, 119 (1951).
Twombly, J., andJ. H. Meyer: Endogenous nitrogen secretions into the digestive tract. J. Nutr.74, 453 (1961).
Verzar, F., andE. J. McDougall: In:F. Verzar andE. J. McDougall, Absorption from the intestine. London: Longmans 1936.
Voit, F.: Z. Biol.29, 325 (1892). Quoted byG. Lusk, 1961, q.v.
Waldmann, T. A.: Protein-losing enteropathy. Gastroenterology50, 422 (1966).
Walser, M., andL. J. Bodenlos: Urea metabolism in man. J. clin. Invest.38, 1617 (1959).
Wang, H. L., andH. A. Waisman: Phenylalanine tolerance tests in patients with leukaemia. J. Lab. clin. Med.57, 73 (1961).
Wasserman, R. H., C. L. Comar, J. G. Schooley, andF. W. Lengemann: Interrelated effects of L-lysine and other dietary factors on the gastrointestinal absorption of calcium in the rat and the chick. J. Nutr.62, 367 (1962).
Weckesser, E. C., J. L. Ankeney, A. F. Portmann, J. W. Price, andF. A. Cebul: Extensive resection of the small intestine followed by vagotomy. Experimental study of fat and nitrogen excretion on dogs. Surgery30, 465 (1951).
West, C. D., J. L. Wilson, andR. Eyles: Blood amino nitrogen levels. Changes in blood amino nitrogen levels following ingestion of proteins and of protein hydrolysate in infants with normal and with deficient pancreatic function. Amer. J. Dis. Child.72, 251 (1946).
White, A. G. C., andW. Parson: Comparative studies on nitrogen excretion. Arch. Biochem.26, 205 (1950).
Whitfield, A. G. W., A. Gourevitch, andG. Thomas: Metabolic effects of total pancreatectomy in man. Lancet1952 I, 180.
Wiggans, D. S., andJ. M. Johnston: The absorption of peptides. Biochim. biophys. Acta (Amst.)32, 69 (1959).
Wilbrandt, W., andT. Rosenberg: The concept of carrier transport and its corollaries in pharmacology. Phermacol. Rev.13, 109 (1961).
Wilson, T. H.: In:T. H. Wilson, Intestinal absorption. Philadelphia and London: W. B. Saunders Co. 1962 (see p. 122).
—— Membrane transport of vitamin B12. Medicine (Baltimore)43, 669 (1964).
——, andC. C. Lin: Active transport by intestine of fetal and newborn rabbits. Amer. J. Physiol.199, 1030 (1960).
——, andG. Wiseman: The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. J. Physiol. (Lond.)123, 116 (1954a).
—— Metabolic activity of the small intestine of the rat and golden hamster (Mesocricetus auratus). J. Physiol. (Lond.)123, 126 (1954b).
Wiseman, G.: Active stereochemically selective absorption of amino-acids from rat small intestine. J. Physiol. (Lond.)114, 7 P (1951).
—— Absorption of amino acids using anin vitro technique. J. Physiol. (Lond.)120, 63 (1953).
—— Preferential transference of amino acid mixtures by sacs of everted small intestine of the golden hamster (Mesocricetus auratus). J. Physiol. (Lond.)127, 414 (1955).
—— Active transport of amino acids by sacs of everted small intestine of the golden hamster (Mesocricetus auratus). J. Physiol. (Lond.)133, 626 (1956).
—— Effect of pyridoxal on the active transport of amine acids by sacs of everted intestine of the golden hamster (Mesocricetus auratus). J. Physiol. (Lond.)136, 203 (1957).
—— Sac of everted intestine technic of study of intestinal absorptionin vitro. Meth. med. Res.9, 287 (1961).
—— Absorption from the intestine. New York and London: Academic Press 1964.
——, andF. N. Ghadially: Effect of sarcoma RD3 on intestinal active absorption of glucose and L-histidine. Brit. J. Cancer13, 282 (1959).
Wollaeger, E. E., M. W. Comfort, O. T. Clegett, andA. E. Osterberg: Efficiency of gastrointestinal tract after resection of head of pancreas. J. Amer. med. Ass.137, 838 (1948).
—— ——, andA. E. Osterberg: Total solids, fat and nitrogen in the feces. 3. A study of normal persons taking a test diet containing a moderate amount of fat; comparison with results obtained with normal persons taking a test diet containing large amounts of fat. Gastroenterology6, 83 (1947).
Wright, R. D., andV. Wynn: The digestion of protein in the alimentary canal. Aust. J. exp. Biol. med. Sci.29, 281 (1951).
Zetzel, L., andB. M. Banks: Intestinal absorption of aminoacid mixture in normal subjects. Amer. J. dig. Dis.8, 21 (1941).
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Deutsche Übersetzung: Dr.J. Eisenburg, München.
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Matthews, D.M. Absorption und Malabsorption von Eiweiß-Verdauungsprodukten. Klin Wochenschr 47, 397–414 (1969). https://doi.org/10.1007/BF01745784
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DOI: https://doi.org/10.1007/BF01745784