Abstract
Hepatitis viruses and the acquired immunodeficiency viruses often infect intravenous drug addicts (IVDAs). Our study includes 255 IVDAs (26 females and 229 males, aged 20–35 years) from Cagliari. Of 255 subjects examined, 207 (81.1%) were positive for anti-HCV and 84 (32.9%) for anti-HIV. Nineteen (7.4%) subjects were HBsAg carriers, and 12 of these (63%) had an HDV super-infection. Markers of previous HBV infections were tested in 223 cases and 137 (61.4%) were found positive; of these 14 (10.2%) also had HDV infection. Of the 223 drug addicts examined for all infection markers, 18 (8%) were negative to all markers, 46 (20.6%) were positive to only one, 89(39.9%) were positive to two, 64 (28.7%) to three and 6 (2.6%) were positive to all. Subjects with a single infection were significantly fewer than those with multiple infections. The correlations studied among the various markers did not point out any statistically significant associations. Even so, a previous HBV infection was more common while active HBV/HDV infections were less common among subjects with anti-HCV; HDV infection was more common among HIV-positive subjects. In HBsAg carriers neither HBV-DNA nor HCV-RNA was detected; HCV-RNA was found more frequently in anti-HIV positive subjects than in subjects with the anti-HCV isolate.
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Homann C, Krogsgaard K, Pederson C, et al. High incidence of hepatitis B infection and evolution in patients with advanced HIV infection. J AIDS 1991; 4: 416–420.
Hoofnagle JH, Rustgi VK, Gérin JL, et al. Hepatitis B virus infection in the acquired immune deficiency syndrome. Ann Int Med 1984; 101: 795–797.
Caredda F, Antinori S, Coppin P, et al. The influence of HIV infection on acute and chronic HBsAg positive hepatitis. In: Rizzetto M, Gérin JL, Purcell RH, eds, The Hepatitis Delta Virus. New York: Wiley-Liss, 1991: 365–375.
Tor J, Llibre JM, Carbonell M, et al. Sexual transmission of HCV and its relation with hepatitis B Virus and HIV. Br Med J 1990; 301: 1130–1133.
Heumer HP, Prodinger WM, Larcher C, et al. Correlation of HCV antibodies with HIV1 seropositivity in intravenous drug addicts. Infection 1990; 18 (2): 122.
Melbye M, Biggar RJ, Wan Tzin P, Krogsgaard K, Ebbesen P, Becker NG. Sexual transmission of hepatitis C virus: Cohort study (1981–89) among European homosexual men. Br Med J 1990; 301: 210–212.
Masia G, Scarpa B, Uccheddu P, Contu P. Epidemiology of hepatitis B in south Sardinia. L'Igiene Moderna 1990; 2: 221–229.
Mantero G, Zonaro A, Bertolo P, Primi D. DNA enzyme immunoassay (DEIA): A general method for detecting polymerase chain reaction products based on anti-DNA antibody. Clin Chem 1991; 37: 422–429.
Garson JA, Tedder RS, Briggs M, Tuke P, Glazebrook JA, Trute A, Parker D, Barbara JAJ, Contreras M, Aloysius S. Detection of hepatitis C viral sequences in blood donations by ‘nested’ polymerase chain reaction and prediction of infectivity. Lancet 1990; 335: 1419–1422.
Imberti L, Cariani E, Bettinardi A, Zonaro A, Albertini A, Primi D. An immunoassay for specific amplified HCV sequences. J Virol Meth 1991; 34: 233–243.
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Coppola, R.C., Manconi, R., Piro, R. et al. HCV, HIV, HBV and HDV infections in intravenous drug addicts. Eur J Epidemiol 10, 279–283 (1994). https://doi.org/10.1007/BF01719350
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DOI: https://doi.org/10.1007/BF01719350