Abstract
Details of the smoking history were obtained from 288 patients with ulcerative colitis who were more than 15 years of age when colitis developed. Men who had previously smoked presented with colitis at a later age than lifelong non-smokers (mean age difference 15.2 years). The proportion of ex-smokers in this group of patients with colitis was more than twice that expected in the general population. The interval between cessation of smoking and subsequent onset of colitis in ex-smokers was found to be relatively short and in two-thirds of patients occurred within seven years. A tentative model to explain the association between smoking and subsequent colitis is proposed. We suggest that whilst current smokers may have a lower incidence of colitis, ex-smokers appear to be at increased risk of developing the disease. An alternative explanation is that smoking may act in a manner analogous to sulphasalazine.
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References
Harries AD, Baird A, Rhodes J (1982) Non-smoking: a feature of ulcerative colitis. Br Med J 284:706
Jick H, Walker AM (1983) Cigarette smoking and ulcerative colitis. New Engl J Med 308:261–263
Bures J, Fixa B, Komarkova O, Fingerland A (1982) Non-smoking: a feature of ulcerative colitis (letter). Br Med J 285:440
Logan RF, Edmond M, Somerville KW, Langman MJ (1984) Smoking and ulcerative colitis. Br Med J 288:751–753
Holdstock G, Savage D, Harman M, Wright R (1984) Should patients with inflammatory bowel disease smoke? Br Med J 288:362
Benoni C, Nilsson A (1984) Smoking habits in patients with inflammatory bowel disease. Scand J Gastroenterol 19:824–830
Ricci R, Carla di Paola M, Ricci F, Pallone F, Paoluzi P (1986) Smoking and inflammatory bowel disease. Ital J Gastroenterol 18:209–210
Burns DG (1986) Smoking in inflammatory bowel disease and the irritable bowel syndrome. S Afr Med J 69:232–233
Thornton JR, Emmett PM, Heaton KW (1985) Smoking, sugar, and inflammatory bowel disease. Br Med J 290:1786–1787
Porro GB, Panza E (1985) Smoking, sugar, and inflammatory bowel disease (letter). Br Med J 291:971–972
Entrican JH, Sircus W (1986) Chronic inflammatory bowel disease, cigarette smoking and use of oral contraceptives (letter). Br Med J 292:1464
Stermer E, Levy N, Heinrich I, Barkan N (1985) Smoking, sugar and inflammatory bowel disease (letter). Br Med J 291:487
Motley RJ, Rhodes J, Ford GA, Wilkinson SP, Chesner IM, Asquith P, Hellier MD, Mayberry JF (1987) Time relationships between cessation of smoking and onset of ulcerative colitis. Digestion 37:125–127
Gyde SN, Prior P, Alexander F, Evans S, Taylor K, John WG, Waterhouse JAH, Allan RN (1984) Ulcerative colitis: why is the mortality from cardiovascular disease reduced? Quart J Med 53:351–357
Gyde S, Prior P, Dew MJ, Saunders V, Waterhouse JAH (1982) Mortality in ulcerative colitis. Gastroenterology 83:36–43
Vessey M, Jewell D, Smith A, Yeates D, McPherson K (1986) Chronic inflammatory bowel disease, cigarette smoking and use of oral contraceptives: findings in a large cohort study of women of childbearing age. Br Med J 292:1101–1103
Boyko EJ, Koepsell TO, Perera DR, Inui TS (1987) Risk of ulcerative colitis among former and current cigarette smokers. New Engl J Med 316:707–711
De Castella H (1982) Non-smoking: a feature of ulcerative colitis (letter). Br Med J 284:1706
Roberts CJ, Diggle R (1982) Non-smoking: a feature of ulcerative colitis (letter). Br Med J 285:440
Pereva DR, Janeway CM, Field A, Ylvisauer JT, Belic CL (1984) Smoking and ulcerative colitis (letter). Br Med J 288:1533
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Motley, R.J., Rhodes, J., Kay, S. et al. Late presentation of ulcerative colitis in ex-smokers. Int J Colorect Dis 3, 171–175 (1988). https://doi.org/10.1007/BF01648362
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DOI: https://doi.org/10.1007/BF01648362