Skip to main content
Log in

Gallstones, serum lipids, and glucose tolerance among male officials of Self-Defense Forces in Japan

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The relationships of gallstones and the postcholecystectomy state with serum total cholesterol, serum triglycerides, glucose tolerance, and obesity were examined in male officials of the Self-Defense Forces in northern Kyushu, Japan. The study population had rather low rates of gallstones (2%) and prior cholecystectomy (3%). A strong relationship between obesity and gallstones was confirmed. Glucose intolerance was associated with the risk of gallstones independent of obesity. No relation between gallstones and either serum total cholesterol or triglycerides after adjustment for obesity and glucose tolerance was evident. However, the serum concentration of total cholesterol among men having had a cholecystectomy was less than that of those without gallstones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Heaton KW: The epidemiology of gallstones and suggested aetiology. Clin Gastroenterol 2:67–83, 1973

    PubMed  Google Scholar 

  2. Bennion LJ, Grundy SM: Risk factors for the development of cholelithiasis in man. N Engl J Med 229:1161–1167, 1221–1227, 1978

    Google Scholar 

  3. Miyake H, Kuwatsuka T, Tamesue N, and 9 others: Comparative studies on the chemical composition of gallstones in Japan, China and the United States. Fukuoka Igaku Zasshi 54:781–826, 1963

    PubMed  Google Scholar 

  4. Nakayama F, Miyake H: Changing state of gallstone disease in Japan. Am J Surg 120:794–799, 1970

    PubMed  Google Scholar 

  5. Friedman GD, Kannel WB, Dawber TR: The epidemiology of gallbladder disease: Observations in the Framingham study. J Chron Dis 19:273–292, 1966

    PubMed  Google Scholar 

  6. Sampliner RE, Bennett PH, Comess LJ, Rose FA, Burch TA: Gallbladder disease in Pima Indians. Demonstration of high prevalence and early onset by cholecystography. N Engl J Med 283:1358–1364, 1970

    PubMed  Google Scholar 

  7. Diehl AK, Stern MP, Ostrower VS, Friedman PC: Prevalence of clinical gallbladder disease in Mexican-American, Anglo, and Black women. South Med J 73:438–443, 1980

    PubMed  Google Scholar 

  8. Kadziolka R, Nilsson S, Scherstén T: Prevalence of hyperlipoproteinemia in men with gallstone disease. Scand J Gastroenterol 12:353–355, 1977

    PubMed  Google Scholar 

  9. Stout RW, Balmer JP, Henry RW, Buchanan KD: Plasma lipids and gastro-intestinal hormones in subjects with gallstones. Horm Metab Res 10:357–358, 1978

    PubMed  Google Scholar 

  10. Ahlberg J: Serum lipid levels and hyperlipoproteinaemia in gallstone patients. Acta Chir Scand 145:373–377, 1979

    PubMed  Google Scholar 

  11. Van der Linden W: Some biological traits in female gallstone-disease patients. Acta Chir Scand Suppl 269:1–94, 1961

    Google Scholar 

  12. Scragg RKR, Calvert GD, Oliver JR: Plasma lipids and insulin in gall stone disease: A case-control study. Br Med J 289:521–525, 1984

    Google Scholar 

  13. Kaye MD, Kern F: Clinical relationships of gallstones. Lancet 1:1228–1230, 1971

    PubMed  Google Scholar 

  14. Yang R, Arem R, Chan L: Gastrointestinal tract complications of diabetes mellitus. Pathophysiology and management. Arch Intern Med 144:1251–1256, 1984

    PubMed  Google Scholar 

  15. Hanis CL, Ferrel RE, Tulloch BR, Schull WJ: Gallbladder disease epidemiology in Mexican Americans in Starr County, Texas. Am J Epidemiol 122:820–829, 1985

    PubMed  Google Scholar 

  16. Strom BL, Tamragouri RN, Morse ML, Lazar EL, West SL, Stolley PD, Jones JK: Oral contraceptives and other risk factors for gallbladder disease. Clin Pharmacol Ther 39:335–341, 1986

    PubMed  Google Scholar 

  17. Nomura AMY, Stemmermann GT, Heilbrun LK, Kagan A: Cholecystectomy, serum cholesterol, and colon cancer. JAMA 247:2100, 1982

    Google Scholar 

  18. Strom BL, Schinnar R, Crown V, Soloway R, Stolley PD, Rosenberg L, Kaufman DW, Helmrich SP, Shapiro S: Does gallbladder removal protect against subsequent myocardial infarction? Am J Epidemiol 124:420–427, 1986

    PubMed  Google Scholar 

  19. Bern RN, Clemett AR: Radiology of the Gallbladder and Bile Ducts. Philadelphia, WB Saunders, 1977

    Google Scholar 

  20. Metreweli C: Practical Abdominal Ultrasound. London, Heinemann Medical Books Ltd, 1978

    Google Scholar 

  21. Cooperberg PL: Gallbladder and bile ducts.In Abdominal Ultrasonography, 2 ed. BB Goldbert (ed). New York, John Wiley & Sons, 1984, pp 121–162

    Google Scholar 

  22. Allain CC, Poon LS, Chan CSG, Richmond W, Fu PC: Enzymatic determination of total serum cholesterol. Clin Chem 20:470–475, 1974

    PubMed  Google Scholar 

  23. Spayd RW, Bruschi B, Burdick BA, Dappen GM, Eikenberry JN, Esders TW, Figueras J, Goodhue CT, LaRossa DD, Nelson RW, Rand RN, Wu TW: Multilayer film elements for clinical analysis: Applications to representative chemical determinations. Clin Chem 24:1343–1350, 1978

    PubMed  Google Scholar 

  24. Fossati P, Prencipe L: Serum triglycerides determined color-imetrically with an enzyme that produces hydrogen peroxide. Clin Chem 28:2077–2080, 1982

    PubMed  Google Scholar 

  25. Okuda J, Miwa I: Mutarotase effect on micro determinations ofd-glucose and its anomers with β-d-glucose oxidase. Anal Biochem 43:312–315, 1971

    PubMed  Google Scholar 

  26. WHO Expert Committee on Diabetes Mellitus: Second Report. WHO Technical Report Series No 646. Geneva, WHO, 1980

    Google Scholar 

  27. SAS Institute: SAS User's Guide: Statistics, 1982 Edition. Cary, North Carolina, SAS Institute Inc, 1982

    Google Scholar 

  28. Harrell FE Jr: The LOGIST procedure.In SUJI Supplemental Library User's Guide, 1983 Edition, SP Joyner (ed). Cary, North Carolina, SAS Institute Inc, 1983, pp 181–202

    Google Scholar 

  29. Bainton D, Davies GT, Evans KT, Gravelle IH: Gallbladder disease. Prevalence in a South Wales industrial town. N Engl J Med 294:1147–1149, 1976

    PubMed  Google Scholar 

  30. Rhomberg HP, Judmair G, Lochs A: How common are gall stones? Br Med J 289:1002, 1984

    Google Scholar 

  31. Yamada K, Nishizawa M, Nomoto K, Ueno M: Cholelithiasis observed in a mass survey of both stomach and gall bladder. Nippon Shokakibyo Gakkai Zasshi 76:1122–1128, 1979

    PubMed  Google Scholar 

  32. Ikeda T, Nishimura K, Amano Y, Yokoyama M, Yoshida H, Fukumoto S, Shimada N: Evaluation of the screening for hepatobiliary diseases in community mass survey. Shokaki-Shudan-Kenshin (J Gastroenterol Mass Survey) 66:14–19, 1985 (in Japanese, title was translated)

    Google Scholar 

  33. Okamura K, Shibata K, Utsumi M, and 25 others: Abdominal mass survey by Ultrasonography. Shokaki-Shudan-Kenshin (J Gastroenterol Mass Survey) 68:25–34, 1985 (in Japanese, title was translated)

    Google Scholar 

  34. Kawamura S, Shinoyama T, Tanabe M, and 9 others: Mass survey for diseases of the liver, gallbladder and pancreas. Shokaki-Shudan-Kenshin (J Gastroenterol Mass Survey) 68:35–39, 1985 (in Japanese, title was translated)

    Google Scholar 

  35. Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO): Prevalence of gallstone disease in an Italian adult female population. Am J Epidemiol 119:796–805, 1984

    Google Scholar 

  36. Pixley F, Wilson D, McPherson K, Mann J: Effect of vegetarianism on development of gall stones in women. Br Med J 291:11–12, 1985

    Google Scholar 

  37. Shaffer EA, Small DM: Biliary lipid secretion in cholesterol gallstone disease. The effect of cholecystectomy and obesity. J Clin Invest 59:828-S40, 1977

    PubMed  Google Scholar 

  38. Lieber MM: The incidence of gallstones and their correlation with other diseases. Ann Surg 135:394–405, 1952

    PubMed  Google Scholar 

  39. Braunsteiner H, Di Pauli R, Sailer S, Sandhofer F: Cholelithiasis und latent diabetische Stoffwechsellage. Schweiz Med Wochenschr 96:44–46, 1966

    PubMed  Google Scholar 

  40. Foster KJ, Griffith AH, Dewbury K, Price CP: Liver disease in patients with diabetes mellitus. Postgrad Med J 56:767–772, 1980

    PubMed  Google Scholar 

  41. Zahor Z, Sternby NH, Kagan A, Uemura K, Venecek R, Vichert AM: Frequency of cholelithiasis in Prague and Malmo: An autopsy study. Scand J Gastroenterol 9:3–7, 1974

    PubMed  Google Scholar 

  42. Ratzmann KP, Meyer LW, Baufeld W: Der intravenöse Glukostoleranztext bei Patienten mit Cholelithiasis und Cirrhosis hepatis. Z Gesamte Inn Med 29:331–333, 1974

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Supported by a Grant-in-Aid from the Ministry of Education (60770442), Japan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kono, S., Kochi, S., Ohyama, S. et al. Gallstones, serum lipids, and glucose tolerance among male officials of Self-Defense Forces in Japan. Digest Dis Sci 33, 839–844 (1988). https://doi.org/10.1007/BF01550973

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01550973

Key words

Navigation