Abstract
Using14C-labeled arachidonic acid as precursor for in vitro prostaglandin synthesis, the effect of an antacid containing Al (OH)3, Mg(OH)2 and CaCO3 on endogenous prostaglandin synthesis was investigated in antral and duodenal mucosa of healthy volunteers. After three weeks of treatment with a high-dose antacid, there was no detectable change in the total capacity of the mucosa for prostaglandin synthesis, but the prostaglandin profile was markedly altered. The relative amounts of PGE2 and PGF2α synthesized by antral and duodenal mucosa increased at the expense of the prostaglandinsA2/B2, thromboxane A2, and prostacyclin. In a short-term study, this change was not observed following a single antacid dose within 1 hr after application. It is concluded that long-term antacid treatment may alter the prostaglandin pattern formed by gastroduodenal mucosa and this may be related to its therapeutic effect.
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Isenberg JI, Peterson WL, Elashoff JD, Sandersfeld MA, Reedy TJ, Ippoliti AF, Van Deventer GM, Frankl H, Longstreth GF, Anderson DS: Healing of benign gastric ulcer with low-dose antacid or cimetidine. A double-blind, randomized, placebo-controlled trial. N Engl J Med 308:1319–1324, 1983
Englert E, Freston JW, Graham DY, Finkelstein W, Kruss DM, Priest RJ, Raskin JB, Rhodes JB, Rogers AI, Wenger J, Wilcox LL, Crossley RJ: Cimetidine, antacid, and hospitalization in the treatment of benign gastric ulcer. A multicenter double blind study. Gastroenterology 74:416–425, 1978
Fedeli G, Anti M, Rapaccini GL, De Vitis I, Butti A, Civello IM: A controlled study comparing cimetidine treatment to an intensive antacid regimen in the therapy of uncomplicated duodenal ulcer. Dig Dis Sci 24:758–762, 1979
Peterson WL, Sturdevant RAL, Frankl HD, Richardson ChT, Isenberg JI, Elashoff JD, Sones JQ, Gross RA, McCallum RW, Fordtran JS: Healing of duodenal ulcer with an antacid regimen. N Engl J Med 297:341–345, 1977
Etienne A, Fimmel CJ, Rey JP, Blum AL: Long-lasting effect of an Al/Mg liquid antacid on nocturnal intragastric acidity recorded by continuous pH-metry. Gastroenterology 86:1071, 1984
Berstad A, Rydning A, Aadland E, Kolstad B, Frislid K, Aaseth J: Controlled clinical trial of duodenal ulcer healing with antacid tablets. Scan J Gastroenterol 17:953–959, 1982
Lam SK, Lam KC, Lai CL, Yeung CK, Yam LYC, Wong WS: Treatment of duodenal ulcer with antacid and Sulpiride. A double-blind controlled study. Gastroenterology 76:315–322, 1978
Hagel J, Renner H, Hirsch M, Weig G, Kaduk B, Ruppin H, Domschke W: Gastric cytoprotection by antacids and Papaverine in rats. Hepato-Gastroenterol 29:271–274, 1982
Szeleni I, Postius S, Engler H: Prostaglandin content in the rat gastric mucosa during healing of chronic ulcers induced by acetic acid. Agents Actions 13:207–209, 1983
Szeleni I, Postius S: Further evidence for gastroprotection induced by aluminum hydroxide in the rat. Z Gastroenterol 24:717–721, 1986
Reimann H-J, Schmidt U, Wendt P, Dorsch W, Von Sanden H, Von der Ohe M, Lewin J, Ultsch B: Die Wirkung von Antazida auf den Gehalt von Gewebshistamin und Prostaglandinen (PGE2) in der Magenmukosa. Fortschr Med 102:25–26, 1984
Preclik G, Stange EF, Gerber K, Fetzer G, Horn H, Ditschuneit H: Stimulation of mucosal prostaglandin synthesis in human stomach and duodenum by antacid treatment. Gut 30:148–151, 1989
Boughton-Smith NK, Hawkey CJ, Whittle BJR: Biosynthesis of lipoxygenase and cyclooxygenase products from [14C]arachidonic acid by human colonic mucosa. Gut 24:1176–1182, 1983
Ahlquist DA, Madson TH, Romero JC, Dozois RR, Malagelada J-R: Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. Am J Physiol 244:G131-G137, 1983
Aly A, Johansson C, Slezak P, Green K: Bioconversion of arachidonic acid in the human gastrointestinal tract. Biochem Med 31:319–331, 1984
Preclik G, Stange EF, Arnold D, Kraft O, Schneider A, Ditschuneit H: Prostaglandin synthesis along the gastrointestinal tract of the rabbit: Differences in total synthesis and profile. Prostaglandins 33:459–478, 1987
Ohki S, Ogino N, Yamamoto S, Hayaishi O: Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. J Biol Chem 254:829–836, 1979
Preclik G, Stange EF, Kraft O, Arnold D, Schneider A, Ditschuneit H: An optimized assay for endogenous prostaglandin synthesis in rabbit and human gastrointestinal mucosa. Eur J Clin Invest 16:A29, 1986
Goswami SK, Kinsella JE: Separation of prostaglandins A, B, D, E, F, thromboxane and 6-keto prostaglandin F1α by thin-layer chromatography. J Chromatogr 209:334–336, 1981
Korte K, Casey ML: Separation of prostanoids by one-dimensional thin-layer chromatography. J Chromatogr 6:55–62, 1983
Stange EF, Preclik G, Ditschuneit H: Prostaglandin biosynthesis in gastroduodenal mucosa: Methodological difficulties and their implications. Scand J Gastroenterol 21:121–125, 1986
Ahlquist DA, Dozois RR, Zinsmeister AR, Malagelada J-R: Duodenal prostaglandin synthesis and acid load in health and in duodenal ulcer disease. Gastroenterology 85:522–528, 1983
Assouline G, Leibson V, Danon A: Stimulation of prostaglandin output from rat stomach by hypertonic solutions. Eur J Pharmacol 44:271–273, 1977
Whittle BJR: Cellular mediators in gastric damage: Actions of thromboxane A2 and its inhibitors.In Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract. A Allen, et al (eds). New York, Raven Press, pp 295–301, 1984
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Preclik, G., Stange, E.F., Gerber, K. et al. Effect of antacid treatment on endogenous prostaglandin synthesis in human antral and duodenal mucosa. Digest Dis Sci 34, 1860–1864 (1989). https://doi.org/10.1007/BF01536703
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DOI: https://doi.org/10.1007/BF01536703