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Human genes encoding prothrombin and ceruloplasmin map to 11p11–q12 and 3q21–24, respectively

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Somatic Cell and Molecular Genetics

Abstract

The gene for human prothrombin, or factor II (F2) has been assigned to 11p11–q12 by the combined use of a panel of somatic cell hybrid DNAs and in situ hybridization, using both cDNA and genomic probes. In addition, the cDNA probe for F2 recognizes a homologous sequence which has been tentatively mapped to the X chromosome. Similar approaches have been used to confirm the assignment of the ceruloplasmin gene, but to regionally localize it more proximally than previously reported (3q21–q24). These results provide further evidence that genes encoding the coagulation factors and related proteins are dispersed throughout the human genome.

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Literature cited

  1. Jackson, C.M., and Nemerson, Y. (1980).Annu. Rev. Biochem. 49:765–811.

    PubMed  Google Scholar 

  2. McKusick, V.A. (1983).Mendelian Inheritance in Man. Catalogs of Autosomal Dominant, Autosomal Recessive and X-Linked Phenotypes, 6th ed. (Johns Hopkins University Press, Baltimore).

    Google Scholar 

  3. Vehar, G.A., Keyt, B., Eaton, D., Rodriquez, H., O'Brien, D.P., Rotblat, F., Oppermann, H., Keck, R., Wood, W.I., Harkins, R.N., Tuddenham, E.G.D., Lawn, R.M., and Capon, D.J. (1984).Nature 312:337–342.

    PubMed  Google Scholar 

  4. Toole, J.J., Knopf, J.L., Wozney, J.M., Sultzman, L.A., Buecker, J.L., Pittman, D.D., Kaufman, R.J., Brown, E., Shoemaker, C., Orr, E.C., Amphlett, G.W., Foster, W.B., Coe, M.L., Knutson, G.J., Fass, D.N., and Hewick, R.M. (1984).Nature 312:342–347.

    PubMed  Google Scholar 

  5. Church, W.R., Jernigan, R.L., Toole, J., Hewick, R.M., Knopf, J., Knutson, G.J., Nesheim, M.E., Mann, K.G. and Fass, D.N. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:6934–6937.

    PubMed  Google Scholar 

  6. Takahashi, N., Ortel, T., and Putman, F.W. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:390–394.

    PubMed  Google Scholar 

  7. Yang, F., Naylor, S.L., Luin, J.B., Cutshaw, S., McCombs, J.L., Naberhans, K.H., McGill, J.R., Adrian, G.S., Moore, C.M., Barnett, D.R. (1986).Proc. Natl. Acad. Sci. U.S.A. 83:3257–3261.

    PubMed  Google Scholar 

  8. Koschinsky, M.L., Funk, W.D., van Oost, B.A., MacGillivray, R.T.A. (1986).Proc. Natl. Acad. Sci. U.S.A. 83:5086–5090.

    PubMed  Google Scholar 

  9. Yang, F., Lum, J.B., McGill, J.R., Moore, C.M., Naylor, S.L., van Bragt, P.H., Baldin, W.D., Bowman, B.H. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:2752–2756.

    PubMed  Google Scholar 

  10. Rabin, M., McClelland, A., Kuhn, L., and Ruddle, F.H. (1985).Am. J. Hum. Genet. 37:1112–1116.

    PubMed  Google Scholar 

  11. McKusick, V.A., and Conneally, P.M. (1984).Cytogenet. Cell Genet. 37:205–209.

    PubMed  Google Scholar 

  12. MacGillivray, R.T.A., Irwin, D.M., Guinto, E.R., and Stone, J.C. (1986).Ann. N.Y. Acad. Sci. (in press).

  13. Lawn, R.M., Fritsch, E.F., Parker, R.C., Blake, G., and Maniatis, T. (1978).Cell 15:1157–1174.

    PubMed  Google Scholar 

  14. Degen, S.J.F., MacGillivray, R.T.A., and Davie, E.W. (1983).Biochemistry 22:2087–2097.

    PubMed  Google Scholar 

  15. Vieira, J., and Messing, J. (1982).Gene 19:259–268.

    PubMed  Google Scholar 

  16. Donald, L.J., Wang, H.S., Kamali, V., Liebert, L., Rudner-Marion, M., Cameron, E.S., Riddell, D.C., Vust, A., Wrogemann, K., and Hamerton, J.L. (1983).Cytogenet. Cell Genet. 37:453A.

    Google Scholar 

  17. Southern, E.M. (1975).J. Mol. Biol. 98:503–517.

    PubMed  Google Scholar 

  18. Lin, C.C., Draper, P.N., and DeBrackeleer, M. (1985).Cytogenet. Cell. Genet. 39:269–274.

    PubMed  Google Scholar 

  19. Harper, M.A., and Saunders, G.F. (1981).Chromosoma 83:431–439.

    PubMed  Google Scholar 

  20. Royle, N.J., Fung, M.R., MacGillivray, R.T.A., and Hamerton, J.L. (1986).Cytogenet. Cell Genet. 41:185–188.

    PubMed  Google Scholar 

  21. Chance, P.F., Dyer, K.A., Kurachi, K., Yoshitake, S., Ropers, H.H., Wieacker, P., and Gartier, S.M. (1983).Hum. Genet. 65:207–208.

    PubMed  Google Scholar 

  22. Boyd, Y., Buckle, V.J., Munroe, E.A., Choo, K.H., Migeon, B.R., and Craig, I.W. (1984).Ann. Hum. Genet. 48:145–152.

    PubMed  Google Scholar 

  23. Camerino, G., Grzeschik, K.H., Jaye, M., De La Jalle, H., Tolstoshev, P., Lecocq, J.P., Heilig, R., and Mandel, J.L. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:498–502.

    PubMed  Google Scholar 

  24. Degen, S.J.F., MacGillivray, R.T.A., and Davie, E.W. (1983). InManipulation and Expression of Genes in Eukaryotes, (eds.) Nagley, P., Linnane, A.W., Peacock, W.J., and Pateman, J.A. (Academic Press, Sydney), pp. 13–16.

    Google Scholar 

  25. Human Gene Mapping 8 (1985). Conference.Cytogenet. Cell Genet. 40:1–823.

    Google Scholar 

  26. Kant, J.A., Forance, A.J., Saxe, D., Simon, M.I., McBride, O.W., and Crabtree, G.R. (1985).Proc. Natl. Acad. Sci. U.S.A. 82:2344–2348.

    PubMed  Google Scholar 

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Author notes

  1. N. J. Royle

    Present address: Department of Genetics, University of Leicester, Leicester, Great Britain

Authors and Affiliations

  1. Department of Human Genetics, University of Manitoba, Winnipeg

    J. L. Hamerton

  2. Department of Biochemistry, University of British Columbia, Vancouver, Canada

    D. M. Irwin, M. L. Koschinsky & R. T. A. MacGillivray

Authors
  1. N. J. Royle
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  2. D. M. Irwin
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  3. M. L. Koschinsky
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  4. R. T. A. MacGillivray
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  5. J. L. Hamerton
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Royle, N.J., Irwin, D.M., Koschinsky, M.L. et al. Human genes encoding prothrombin and ceruloplasmin map to 11p11–q12 and 3q21–24, respectively. Somat Cell Mol Genet 13, 285–292 (1987). https://doi.org/10.1007/BF01535211

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  • DOI: https://doi.org/10.1007/BF01535211

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